SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tqd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_1
(HIV-II PROTEASE)		 3tqd 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE
(Coxiella
burnetii) 		5 / 12 GLY A  62
ALA A  63
ILE A   7
ILE A  54
ILE A  47
 None
 0.96A 1hshC-3tqdA:
undetectable		 1hshC-3tqdA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_1
(PROTEASE)		 3tqd 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE
(Coxiella
burnetii) 		4 / 7 ASP A 100
ILE A   6
ALA A  58
ILE A  30
 None
 0.76A 1n49A-3tqdA:
undetectable		 1n49A-3tqdA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_A_ROFA101_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3tqd 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE
(Coxiella
burnetii) 		5 / 12 ASP A 115
LEU A 112
TYR A 189
ILE A 223
PHE A 156
 None
 1.37A 1xmuA-3tqdA:
undetectable		 1xmuA-3tqdA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_B_ROFB102_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3tqd 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE
(Coxiella
burnetii) 		5 / 12 ASP A 115
LEU A 112
TYR A 189
ILE A 223
PHE A 156
 None
 1.39A 1xmuB-3tqdA:
undetectable		 1xmuB-3tqdA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP9_D_SPMD230_1
(LS-24)		 3tqd 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE
(Coxiella
burnetii) 		3 / 3 GLU A 240
GLU A 136
ASN A 139
 None
 0.87A 3lp9B-3tqdA:
undetectable
3lp9D-3tqdA:
undetectable		 3lp9B-3tqdA:
19.26
3lp9D-3tqdA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG505_1
(HEMOLYTIC LECTIN
CEL-III)		 3tqd 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE
(Coxiella
burnetii) 		4 / 5 GLU A  59
GLY A  62
TYR A  34
GLN A  31
 None
None
None
ACT  A 400 (-4.5A)
 1.46A 3w9tG-3tqdA:
undetectable		 3w9tG-3tqdA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQB_B_017B101_2
(ASPARTYL PROTEASE)		 3tqd 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE
(Coxiella
burnetii) 		5 / 10 LEU A 242
GLY A  18
ASP A  12
ILE A  30
VAL A 236
 None
 0.98A 4dqbB-3tqdA:
undetectable		 4dqbB-3tqdA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQE_B_017B101_2
(ASPARTYL PROTEASE)		 3tqd 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE
(Coxiella
burnetii) 		5 / 10 LEU A 242
GLY A  18
ASP A  12
ILE A  30
VAL A 236
 None
 0.98A 4dqeB-3tqdA:
undetectable		 4dqeB-3tqdA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQH_B_017B101_2
(WILD-TYPE HIV-1
PROTEASE DIMER)		 3tqd 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE
(Coxiella
burnetii) 		5 / 10 LEU A 242
GLY A  18
ASP A  12
ILE A  30
VAL A 236
 None
 1.00A 4dqhB-3tqdA:
undetectable		 4dqhB-3tqdA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_1
(ANDROGEN RECEPTOR)		 3tqd 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE
(Coxiella
burnetii) 		5 / 12 GLY A  99
GLN A  98
VAL A 184
ILE A  24
VAL A 245
 None
 1.14A 4ok1A-3tqdA:
undetectable		 4ok1A-3tqdA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_1
(ANDROGEN RECEPTOR)		 3tqd 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE
(Coxiella
burnetii) 		5 / 12 GLY A  99
GLN A  98
VAL A 184
ILE A  24
VAL A 245
 None
 1.21A 4okwA-3tqdA:
undetectable		 4okwA-3tqdA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QKN_A_JMSA602_1
(ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO)		 3tqd 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE
(Coxiella
burnetii) 		4 / 8 PRO A 130
ARG A 182
LEU A 127
SER A 230
 None
 1.22A 4qknA-3tqdA:
undetectable		 4qknA-3tqdA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_A_ADNA401_1
(ADENOSINE KINASE)		 3tqd 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE
(Coxiella
burnetii) 		5 / 12 ILE A   7
ALA A  63
GLY A  62
ALA A  58
ILE A  47
 None
 0.82A 5kb6A-3tqdA:
undetectable		 5kb6A-3tqdA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_B_ADNB401_1
(ADENOSINE KINASE)		 3tqd 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE
(Coxiella
burnetii) 		5 / 12 ILE A   7
ALA A  63
GLY A  62
ALA A  58
ILE A  47
 None
 0.84A 5kb6B-3tqdA:
undetectable		 5kb6B-3tqdA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_E_ASCE1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 3tqd 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE
(Coxiella
burnetii) 		4 / 7 HIS A 183
HIS A 224
ILE A 223
TYR A 187
 None
 1.16A 5kkzC-3tqdA:
undetectable
5kkzE-3tqdA:
undetectable		 5kkzC-3tqdA:
22.63
5kkzE-3tqdA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_K_ASCK1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 3tqd 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE
(Coxiella
burnetii) 		4 / 7 HIS A 224
ILE A 223
TYR A 187
HIS A 183
 None
 1.16A 5kkzK-3tqdA:
undetectable
5kkzQ-3tqdA:
undetectable		 5kkzK-3tqdA:
20.18
5kkzQ-3tqdA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH8_A_ACTA302_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3tqd 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE
(Coxiella
burnetii) 		3 / 3 CYH A 128
MET A 225
ASN A 151
 None
 1.17A 5qh8A-3tqdA:
undetectable		 5qh8A-3tqdA:
22.10