SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tqe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ESW_A_ACRA652_1
(AMYLOMALTASE)		 3tqe MALONYL-COA-[ACYL-CA
RRIER-PROTEIN]
TRANSACYLASE
(Coxiella
burnetii) 		4 / 6 GLY A 277
ASP A  71
GLY A  91
SER A  14
 None
 0.94A 1eswA-3tqeA:
undetectable		 1eswA-3tqeA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3002_1
(SERUM ALBUMIN)		 3tqe MALONYL-COA-[ACYL-CA
RRIER-PROTEIN]
TRANSACYLASE
(Coxiella
burnetii) 		4 / 8 GLN A  64
LEU A  68
LEU A  45
TYR A  43
 GLY  A 314 ( 4.2A)
None
None
None
 1.24A 1hk2A-3tqeA:
undetectable		 1hk2A-3tqeA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_2
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 3tqe MALONYL-COA-[ACYL-CA
RRIER-PROTEIN]
TRANSACYLASE
(Coxiella
burnetii) 		4 / 6 ARG A 118
GLN A 251
ASN A 232
ASN A 242
 GLY  A 314 (-3.2A)
None
None
GLY  A 315 ( 4.8A)
 1.19A 2nyrA-3tqeA:
2.1		 2nyrA-3tqeA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_2
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 3tqe MALONYL-COA-[ACYL-CA
RRIER-PROTEIN]
TRANSACYLASE
(Coxiella
burnetii) 		4 / 6 PHE A   9
GLN A 251
ASN A 232
ASN A 242
 None
None
None
GLY  A 315 ( 4.8A)
 1.12A 2nyrA-3tqeA:
2.1		 2nyrA-3tqeA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_1
(DIHYDROFOLATE
REDUCTASE)		 3tqe MALONYL-COA-[ACYL-CA
RRIER-PROTEIN]
TRANSACYLASE
(Coxiella
burnetii) 		3 / 3 GLU A 266
GLN A   3
ARG A 310
 None
 0.94A 2w3bB-3tqeA:
undetectable		 2w3bB-3tqeA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 3tqe MALONYL-COA-[ACYL-CA
RRIER-PROTEIN]
TRANSACYLASE
(Coxiella
burnetii) 		5 / 12 LEU A 100
LEU A 106
ALA A 111
VAL A 115
LEU A  57
 None
 1.27A 3b0wA-3tqeA:
undetectable		 3b0wA-3tqeA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_B_SVRB516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 3tqe MALONYL-COA-[ACYL-CA
RRIER-PROTEIN]
TRANSACYLASE
(Coxiella
burnetii) 		4 / 7 PRO A 225
GLY A 104
ALA A 103
ALA A  98
 None
 0.85A 3ur0B-3tqeA:
1.1		 3ur0B-3tqeA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3tqe MALONYL-COA-[ACYL-CA
RRIER-PROTEIN]
TRANSACYLASE
(Coxiella
burnetii) 		5 / 12 VAL A 256
LEU A 282
VAL A 115
ARG A 118
THR A 261
 None
None
None
GLY  A 314 (-3.2A)
None
 1.25A 4eckA-3tqeA:
undetectable		 4eckA-3tqeA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_C_ECNC403_1
(FLAVOHEMOGLOBIN)		 3tqe MALONYL-COA-[ACYL-CA
RRIER-PROTEIN]
TRANSACYLASE
(Coxiella
burnetii) 		5 / 9 THR A  33
PHE A  34
VAL A 112
VAL A  49
LEU A  45
 None
 1.06A 4g1bC-3tqeA:
undetectable		 4g1bC-3tqeA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA-1B
CHAIN)		 3tqe MALONYL-COA-[ACYL-CA
RRIER-PROTEIN]
TRANSACYLASE
(Coxiella
burnetii) 		4 / 6 ASP A 216
PRO A  65
TYR A  97
LEU A  94
 None
None
None
GLY  A 314 ( 4.6A)
 1.08A 5bmvB-3tqeA:
undetectable		 5bmvB-3tqeA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H4D_A_BBIA403_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 3tqe MALONYL-COA-[ACYL-CA
RRIER-PROTEIN]
TRANSACYLASE
(Coxiella
burnetii) 		4 / 6 PHE A  34
PHE A 108
GLU A 116
VAL A 115
 None
 1.16A 5h4dA-3tqeA:
undetectable		 5h4dA-3tqeA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_1
(REGULATORY PROTEIN
TETR)		 3tqe MALONYL-COA-[ACYL-CA
RRIER-PROTEIN]
TRANSACYLASE
(Coxiella
burnetii) 		4 / 7 GLN A  12
GLY A  13
ILE A 195
GLN A 167
 GLY  A 314 (-4.0A)
None
None
None
 1.15A 5vlmC-3tqeA:
undetectable		 5vlmC-3tqeA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 3tqe MALONYL-COA-[ACYL-CA
RRIER-PROTEIN]
TRANSACYLASE
(Coxiella
burnetii) 		4 / 6 TYR A  43
GLN A  59
GLU A 116
ALA A  37
 None
 1.25A 6djzB-3tqeA:
undetectable		 6djzB-3tqeA:
23.17