SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tqh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4001_1
(SERUM ALBUMIN)		 3tqh QUINONE
OXIDOREDUCTASE
(Coxiella
burnetii) 		5 / 9 LEU A 275
LEU A 142
VAL A 162
GLY A 163
ALA A 134
 None
None
NDP  A 500 (-3.7A)
None
None
 1.10A 1e7aA-3tqhA:
undetectable		 1e7aA-3tqhA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HBP_A_RTLA184_0
(RETINOL BINDING
PROTEIN)		 3tqh QUINONE
OXIDOREDUCTASE
(Coxiella
burnetii) 		5 / 11 LEU A 126
ALA A 138
ALA A 134
VAL A 314
GLN A 127
 SO4  A 320 (-3.9A)
None
None
None
None
 1.30A 1hbpA-3tqhA:
undetectable		 1hbpA-3tqhA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_A_ID2A1_0
(THYMIDINE KINASE)		 3tqh QUINONE
OXIDOREDUCTASE
(Coxiella
burnetii) 		5 / 12 HIS A  38
ILE A  77
ILE A  35
ALA A 106
GLU A  75
 None
 1.32A 1ki7A-3tqhA:
undetectable		 1ki7A-3tqhA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 3tqh QUINONE
OXIDOREDUCTASE
(Coxiella
burnetii) 		4 / 8 LEU A  64
LEU A  60
LYS A  59
HIS A 101
 None
 1.07A 2wekA-3tqhA:
35.0		 2wekA-3tqhA:
29.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_A_RBFA190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 3tqh QUINONE
OXIDOREDUCTASE
(Coxiella
burnetii) 		5 / 12 THR A 179
GLY A 163
ALA A 166
ALA A 170
LEU A 142
 None
 0.91A 3p5nA-3tqhA:
undetectable		 3p5nA-3tqhA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_B_RBFB190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 3tqh QUINONE
OXIDOREDUCTASE
(Coxiella
burnetii) 		5 / 12 THR A 179
GLY A 163
ALA A 166
ALA A 170
LEU A 142
 None
 0.92A 3p5nB-3tqhA:
undetectable		 3p5nB-3tqhA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_C_C2FC1410_0
(GLYCINE
N-METHYLTRANSFERASE)		 3tqh QUINONE
OXIDOREDUCTASE
(Coxiella
burnetii) 		3 / 3 ARG A  50
PRO A 102
PHE A   9
 None
 1.04A 3thrC-3tqhA:
6.9		 3thrC-3tqhA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX5_B_MIYB1103_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3tqh QUINONE
OXIDOREDUCTASE
(Coxiella
burnetii) 		5 / 12 PHE A  55
GLY A  54
SER A  53
ASP A  46
ILE A  45
 None
None
None
None
SO4  A 319 (-3.9A)
 1.20A 4dx5B-3tqhA:
undetectable		 4dx5B-3tqhA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3tqh QUINONE
OXIDOREDUCTASE
(Coxiella
burnetii) 		5 / 11 ALA A 138
THR A 137
ALA A 141
GLY A 161
GLY A 160
 None
NDP  A 500 (-3.2A)
None
NDP  A 500 (-3.6A)
NDP  A 500 (-3.6A)
 1.11A 4qvwK-3tqhA:
undetectable
4qvwL-3tqhA:
undetectable		 4qvwK-3tqhA:
22.70
4qvwL-3tqhA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3tqh QUINONE
OXIDOREDUCTASE
(Coxiella
burnetii) 		5 / 11 ALA A 138
THR A 137
ALA A 141
GLY A 161
GLY A 160
 None
NDP  A 500 (-3.2A)
None
NDP  A 500 (-3.6A)
NDP  A 500 (-3.6A)
 1.11A 4qvwY-3tqhA:
undetectable
4qvwZ-3tqhA:
undetectable		 4qvwY-3tqhA:
22.70
4qvwZ-3tqhA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8V_B_MIYB1103_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3tqh QUINONE
OXIDOREDUCTASE
(Coxiella
burnetii) 		5 / 12 PHE A  55
GLY A  54
SER A  53
ASP A  46
ILE A  45
 None
None
None
None
SO4  A 319 (-3.9A)
 1.17A 4u8vB-3tqhA:
undetectable		 4u8vB-3tqhA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZOW_A_CLMA500_0
(MULTIDRUG
TRANSPORTER MDFA)		 3tqh QUINONE
OXIDOREDUCTASE
(Coxiella
burnetii) 		5 / 11 LEU A 123
LEU A 139
LEU A 284
ILE A 286
LEU A 169
 None
 0.93A 4zowA-3tqhA:
undetectable		 4zowA-3tqhA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3tqh QUINONE
OXIDOREDUCTASE
(Coxiella
burnetii) 		4 / 7 ILE A 155
LEU A 219
GLY A 160
GLY A 163
 None
NDP  A 500 (-4.4A)
NDP  A 500 (-3.6A)
None
 0.84A 5a06A-3tqhA:
undetectable		 5a06A-3tqhA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_E_SORE1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3tqh QUINONE
OXIDOREDUCTASE
(Coxiella
burnetii) 		4 / 7 ILE A 155
LEU A 219
GLY A 160
GLY A 163
 None
NDP  A 500 (-4.4A)
NDP  A 500 (-3.6A)
None
 0.85A 5a06E-3tqhA:
7.4		 5a06E-3tqhA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3tqh QUINONE
OXIDOREDUCTASE
(Coxiella
burnetii) 		4 / 7 ILE A 155
LEU A 219
GLY A 160
GLY A 163
 None
NDP  A 500 (-4.4A)
NDP  A 500 (-3.6A)
None
 0.85A 5a06F-3tqhA:
7.5		 5a06F-3tqhA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWY_E_010E6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
MAIN PROTEASE)		 3tqh QUINONE
OXIDOREDUCTASE
(Coxiella
burnetii) 		4 / 4 THR A  49
LEU A  68
HIS A 301
GLY A  69
 None
 1.43A 5gwyA-3tqhA:
undetectable		 5gwyA-3tqhA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3tqh QUINONE
OXIDOREDUCTASE
(Coxiella
burnetii) 		4 / 6 VAL A 314
VAL A  37
SER A  73
ILE A 116
 None
 1.01A 5jw1B-3tqhA:
undetectable		 5jw1B-3tqhA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_0
(METHYLTRANSFERASE)		 3tqh QUINONE
OXIDOREDUCTASE
(Coxiella
burnetii) 		5 / 12 ALA A 194
VAL A 177
GLY A 163
GLU A 287
ALA A 134
 None
 1.20A 5n5dA-3tqhA:
8.4		 5n5dA-3tqhA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB307_0
(WELO5)		 3tqh QUINONE
OXIDOREDUCTASE
(Coxiella
burnetii) 		3 / 3 GLU A 107
HIS A  38
VAL A 317
 None
 0.92A 5trqB-3tqhA:
undetectable		 5trqB-3tqhA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXM_A_SAMA402_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 3tqh QUINONE
OXIDOREDUCTASE
(Coxiella
burnetii) 		5 / 12 GLY A 160
GLN A 168
LEU A 278
VAL A 279
ILE A 286
 NDP  A 500 (-3.6A)
None
None
None
None
 1.20A 6bxmA-3tqhA:
4.9		 6bxmA-3tqhA:
23.53