SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tqk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DIT_P_2PPP1_1
(ALPHA-THROMBIN
PEPTIDE INHIBITOR
CVS995)		 3tqk PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE
(Francisella
tularensis) 		4 / 6 LEU A 184
ILE A 167
GLU A 148
PRO A 155
 None
None
ACT  A1002 ( 4.6A)
None
 1.20A 1ditH-3tqkA:
undetectable
1ditP-3tqkA:
undetectable		 1ditH-3tqkA:
20.40
1ditP-3tqkA:
4.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)		 3tqk PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE
(Francisella
tularensis) 		5 / 11 PHE A 158
ALA A 159
LEU A 184
ILE A 167
ALA A 166
 None
 1.04A 1ha2A-3tqkA:
undetectable		 1ha2A-3tqkA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_1
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 3tqk PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE
(Francisella
tularensis) 		5 / 12 ALA A  49
ALA A 181
ALA A 208
PHE A 190
LEU A 259
 None
 1.19A 2nyrA-3tqkA:
undetectable		 2nyrA-3tqkA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_A_P1BA1478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3tqk PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE
(Francisella
tularensis) 		4 / 7 LEU A 150
GLU A 148
ALA A  78
ILE A  75
 None
ACT  A1002 ( 4.6A)
None
None
 0.81A 2xkwA-3tqkA:
undetectable		 2xkwA-3tqkA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		 3tqk PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE
(Francisella
tularensis) 		4 / 8 SER A 277
GLN A 284
VAL A  62
ARG A  97
 None
None
None
ACT  A1002 (-4.2A)
 1.18A 3b9lA-3tqkA:
undetectable		 3b9lA-3tqkA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAV_A_SRYA403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 3tqk PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE
(Francisella
tularensis) 		4 / 8 SER A 327
ASP A 334
ASP A 330
ASP A 271
 None
None
MN  A1001 (-3.3A)
None
 1.27A 3havA-3tqkA:
undetectable		 3havA-3tqkA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA193_1
(DIHYDROFOLATE
REDUCTASE)		 3tqk PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE
(Francisella
tularensis) 		4 / 5 ASP A 137
ILE A  68
PRO A  71
PHE A 112
 None
 1.22A 3s3vA-3tqkA:
undetectable		 3s3vA-3tqkA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8Y_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3tqk PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE
(Francisella
tularensis) 		5 / 12 PHE A 158
GLU A  25
ASP A  30
ILE A  31
ARG A 129
 None
 1.12A 4u8yB-3tqkA:
undetectable		 4u8yB-3tqkA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U95_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3tqk PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE
(Francisella
tularensis) 		5 / 12 PHE A 158
GLU A  25
ASP A  30
ILE A  31
ARG A 129
 None
 1.01A 4u95B-3tqkA:
undetectable		 4u95B-3tqkA:
15.07