SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tql'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S1X_A_NVPA999_1
(REVERSE
TRANSCRIPTASE)
3tql ARGININE-BINDING
PROTEIN

(Coxiella
burnetii)
4 / 8 VAL A 230
TYR A 125
GLY A 231
TYR A  51
None
None
None
ARG  A   1 (-3.6A)
1.00A 1s1xA-3tqlA:
undetectable
1s1xA-3tqlA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOS_A_VIAA1_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)
3tql ARGININE-BINDING
PROTEIN

(Coxiella
burnetii)
5 / 12 TYR A 124
MET A  78
LEU A 245
PHE A  45
ILE A  43
None
1.47A 1xosA-3tqlA:
undetectable
1xosA-3tqlA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TAJ_A_NBOA700_1
(LACTOTRANSFERRIN)
3tql ARGININE-BINDING
PROTEIN

(Coxiella
burnetii)
5 / 7 THR A 126
GLY A 229
ASN A 127
TYR A  54
GLY A 106
None
None
None
None
ARG  A   1 (-4.0A)
1.42A 3tajA-3tqlA:
8.4
3tajA-3tqlA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)
3tql ARGININE-BINDING
PROTEIN

(Coxiella
burnetii)
4 / 4 ASN A 109
SER A  91
LEU A  92
THR A 111
ARG  A   1 (-3.6A)
None
None
None
1.32A 4an2A-3tqlA:
undetectable
4an2A-3tqlA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)
3tql ARGININE-BINDING
PROTEIN

(Coxiella
burnetii)
4 / 8 SER A 188
ARG A 190
GLU A 180
TRP A 204
None
0.86A 4d39A-3tqlA:
undetectable
4d39A-3tqlA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FJP_A_NPSA711_1
(LACTOTRANSFERRIN)
3tql ARGININE-BINDING
PROTEIN

(Coxiella
burnetii)
5 / 6 THR A 126
GLY A 229
ASN A 127
TYR A  54
GLY A 106
None
None
None
None
ARG  A   1 (-4.0A)
1.46A 4fjpA-3tqlA:
8.3
4fjpA-3tqlA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUO_D_08HD501_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT GAMMA-2)
3tql ARGININE-BINDING
PROTEIN

(Coxiella
burnetii)
4 / 8 PHE A 131
PHE A 167
VAL A 220
SER A 128
None
None
None
ARG  A   1 ( 4.3A)
1.25A 6huoC-3tqlA:
undetectable
6huoD-3tqlA:
undetectable
6huoC-3tqlA:
16.83
6huoD-3tqlA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA7_A_TPFA602_0
(CYTOCHROME P450 3A4)
3tql ARGININE-BINDING
PROTEIN

(Coxiella
burnetii)
4 / 7 SER A  91
ALA A  46
ILE A 232
ALA A 233
None
0.85A 6ma7A-3tqlA:
undetectable
6ma7A-3tqlA:
14.91