SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tqp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		 3tqp ENOLASE
(Coxiella
burnetii) 		5 / 10 TYR A 417
PHE A 177
PRO A 145
VAL A 146
ILE A 239
 None
 1.41A 13gsA-3tqpA:
undetectable		 13gsA-3tqpA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A27_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 3tqp ENOLASE
(Coxiella
burnetii) 		5 / 12 SER A 247
GLY A 287
LEU A 272
PHE A 258
GLU A 274
 None
 1.48A 1a27A-3tqpA:
undetectable		 1a27A-3tqpA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_1
(PROTEIN (ADENOSINE
KINASE))		 3tqp ENOLASE
(Coxiella
burnetii) 		5 / 12 LEU A 223
GLY A 155
GLY A 154
ALA A 220
LEU A 214
 None
 1.04A 1bx4A-3tqpA:
undetectable		 1bx4A-3tqpA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_A_NCAA700_0
(EXOTOXIN A)		 3tqp ENOLASE
(Coxiella
burnetii) 		4 / 7 GLY A  34
LEU A 117
ALA A 118
TYR A 121
 None
 0.73A 1dmaA-3tqpA:
undetectable		 1dmaA-3tqpA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_A_NCAA700_0
(EXOTOXIN A)		 3tqp ENOLASE
(Coxiella
burnetii) 		4 / 7 GLY A 360
ALA A 333
TYR A 359
GLU A 304
 None
 0.82A 1dmaA-3tqpA:
undetectable		 1dmaA-3tqpA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2503_0
(FERROCHELATASE)		 3tqp ENOLASE
(Coxiella
burnetii) 		4 / 4 LEU A 200
PRO A 212
LEU A 195
ARG A 194
 None
 1.24A 1hrkB-3tqpA:
undetectable		 1hrkB-3tqpA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB503_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3tqp ENOLASE
(Coxiella
burnetii) 		4 / 6 ALA A 180
TYR A 401
ILE A 169
PRO A 171
 None
 1.02A 1oniB-3tqpA:
undetectable
1oniC-3tqpA:
undetectable		 1oniB-3tqpA:
16.47
1oniC-3tqpA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_E_BEZE509_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3tqp ENOLASE
(Coxiella
burnetii) 		4 / 7 TYR A 401
ILE A 169
PRO A 171
ALA A 180
 None
 0.94A 1oniD-3tqpA:
undetectable
1oniE-3tqpA:
undetectable		 1oniD-3tqpA:
16.47
1oniE-3tqpA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_H_BEZH515_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3tqp ENOLASE
(Coxiella
burnetii) 		4 / 6 ALA A 180
TYR A 401
ILE A 169
PRO A 171
 None
 1.04A 1oniH-3tqpA:
undetectable
1oniI-3tqpA:
undetectable		 1oniH-3tqpA:
16.47
1oniI-3tqpA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U70_A_MTXA187_1
(DIHYDROFOLATE
REDUCTASE)		 3tqp ENOLASE
(Coxiella
burnetii) 		5 / 12 ILE A 151
ALA A 227
PRO A 215
ASN A 216
LEU A 162
 None
 1.22A 1u70A-3tqpA:
undetectable		 1u70A-3tqpA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_1
(VP39)		 3tqp ENOLASE
(Coxiella
burnetii) 		3 / 3 ASP A 396
ARG A 394
ASP A  15
 None
 0.84A 1vptA-3tqpA:
undetectable		 1vptA-3tqpA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_A_BEZA11_0
(CES1 PROTEIN)		 3tqp ENOLASE
(Coxiella
burnetii) 		4 / 4 LEU A 272
SER A 247
LEU A 309
LEU A 299
 None
 1.15A 1yajA-3tqpA:
2.6		 1yajA-3tqpA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3tqp ENOLASE
(Coxiella
burnetii) 		4 / 7 VAL A 196
SER A 202
PHE A 188
HIS A 189
 None
 1.12A 2f78A-3tqpA:
undetectable		 2f78A-3tqpA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1004_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3tqp ENOLASE
(Coxiella
burnetii) 		4 / 7 VAL A 196
SER A 202
PHE A 188
HIS A 189
 None
 1.12A 2f78B-3tqpA:
undetectable		 2f78B-3tqpA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_3
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 3tqp ENOLASE
(Coxiella
burnetii) 		5 / 12 ILE A 387
GLY A 311
ASN A 332
LEU A 424
VAL A 351
 None
 1.26A 2nyrB-3tqpA:
undetectable		 2nyrB-3tqpA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_A_J01A500_1
(ORF12)		 3tqp ENOLASE
(Coxiella
burnetii) 		4 / 8 VAL A  72
LEU A  28
GLY A  34
ALA A 122
 None
 0.90A 2xfsA-3tqpA:
undetectable		 2xfsA-3tqpA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1436_1
(ORF12)		 3tqp ENOLASE
(Coxiella
burnetii) 		4 / 8 VAL A  72
LEU A  28
GLY A  34
ALA A 122
 None
 0.92A 2xh9A-3tqpA:
undetectable		 2xh9A-3tqpA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CSJ_B_CBLB211_0
(GLUTATHIONE
S-TRANSFERASE P)		 3tqp ENOLASE
(Coxiella
burnetii) 		5 / 9 TYR A 417
PHE A 177
PRO A 145
VAL A 146
ILE A 239
 None
 1.46A 3csjB-3tqpA:
undetectable		 3csjB-3tqpA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 3tqp ENOLASE
(Coxiella
burnetii) 		5 / 12 ILE A 151
ALA A 227
PRO A 215
ASN A 216
LEU A 162
 None
 1.38A 3eigA-3tqpA:
undetectable		 3eigA-3tqpA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_A_EAAA212_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 3tqp ENOLASE
(Coxiella
burnetii) 		4 / 7 VAL A  24
ILE A  91
THR A 345
GLY A 114
 None
 1.00A 3gssA-3tqpA:
undetectable		 3gssA-3tqpA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 3tqp ENOLASE
(Coxiella
burnetii) 		5 / 12 THR A 350
LEU A 338
ILE A 362
ILE A 363
LEU A 322
 None
 1.22A 3gwxA-3tqpA:
undetectable		 3gwxA-3tqpA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3004_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3tqp ENOLASE
(Coxiella
burnetii) 		4 / 5 ILE A 330
PHE A 315
ASP A 313
GLU A 290
 None
 1.13A 3kp6A-3tqpA:
0.4
3kp6B-3tqpA:
undetectable		 3kp6A-3tqpA:
17.72
3kp6B-3tqpA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_A_SAMA220_0
(16S RRNA METHYLASE)		 3tqp ENOLASE
(Coxiella
burnetii) 		5 / 12 GLY A 254
ASN A 253
ALA A 294
LEU A 263
LEU A 288
 None
 1.03A 3mteA-3tqpA:
undetectable		 3mteA-3tqpA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_1
(16S RRNA METHYLASE)		 3tqp ENOLASE
(Coxiella
burnetii) 		3 / 3 ASP A  84
GLU A  89
SER A  30
 None
 0.56A 3p2kA-3tqpA:
undetectable		 3p2kA-3tqpA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_0
(16S RRNA METHYLASE)		 3tqp ENOLASE
(Coxiella
burnetii) 		5 / 12 GLY A 254
ASN A 253
ALA A 294
LEU A 263
LEU A 288
 None
 0.96A 3p2kC-3tqpA:
undetectable		 3p2kC-3tqpA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_D_QELD2_2
(GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 3tqp ENOLASE
(Coxiella
burnetii) 		5 / 9 ALA A 376
ILE A 375
THR A 176
PHE A 177
GLU A 408
 None
 1.30A 3qelD-3tqpA:
undetectable		 3qelD-3tqpA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_A_SAMA6734_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 3tqp ENOLASE
(Coxiella
burnetii) 		5 / 12 VAL A 119
ALA A 118
GLY A  34
TYR A  33
LEU A  80
 None
 1.01A 3qxyA-3tqpA:
undetectable		 3qxyA-3tqpA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_A_SAMA484_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 3tqp ENOLASE
(Coxiella
burnetii) 		5 / 11 VAL A 119
ALA A 118
GLY A  34
TYR A  33
LEU A  80
 None
 1.01A 3rc0A-3tqpA:
undetectable		 3rc0A-3tqpA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_B_SAMB480_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 3tqp ENOLASE
(Coxiella
burnetii) 		5 / 12 VAL A 119
ALA A 118
GLY A  34
TYR A  33
LEU A  80
 None
 0.99A 3rc0B-3tqpA:
undetectable		 3rc0B-3tqpA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 3tqp ENOLASE
(Coxiella
burnetii) 		5 / 11 MET A  95
ILE A   8
VAL A 115
VAL A  24
ILE A 112
 None
 1.26A 3rf4A-3tqpA:
undetectable
3rf4C-3tqpA:
undetectable		 3rf4A-3tqpA:
15.04
3rf4C-3tqpA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_B_FUNB202_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 3tqp ENOLASE
(Coxiella
burnetii) 		5 / 11 ILE A 112
MET A  95
ILE A   8
VAL A 115
VAL A  24
 None
 1.24A 3rf4A-3tqpA:
undetectable
3rf4B-3tqpA:
undetectable		 3rf4A-3tqpA:
15.04
3rf4B-3tqpA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_C_FUNC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 3tqp ENOLASE
(Coxiella
burnetii) 		5 / 11 ILE A 112
MET A  95
ILE A   8
VAL A 115
VAL A  24
 None
 1.26A 3rf4B-3tqpA:
undetectable
3rf4C-3tqpA:
undetectable		 3rf4B-3tqpA:
15.04
3rf4C-3tqpA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S53_A_017A201_1
(PROTEASE)		 3tqp ENOLASE
(Coxiella
burnetii) 		6 / 9 ALA A 245
ASP A 244
ILE A 284
GLY A 311
ILE A 314
ILE A 269
 None
MG  A 430 (-2.8A)
None
None
None
None
 1.35A 3s53A-3tqpA:
undetectable		 3s53A-3tqpA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_B_SALB1345_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3tqp ENOLASE
(Coxiella
burnetii) 		4 / 8 LEU A 338
THR A 350
VAL A 351
LEU A 348
 None
 0.81A 3uniB-3tqpA:
undetectable		 3uniB-3tqpA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_A_NCAA1536_0
(DIPHTHERIA TOXIN)		 3tqp ENOLASE
(Coxiella
burnetii) 		4 / 6 GLY A 360
ALA A 333
TYR A 359
GLU A 304
 None
 0.78A 4ae1A-3tqpA:
2.4		 4ae1A-3tqpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G10_A_ACTA301_0
(GLUTATHIONE
S-TRANSFERASE
HOMOLOG)		 3tqp ENOLASE
(Coxiella
burnetii) 		4 / 6 PRO A 147
ILE A 282
TYR A 417
PHE A 423
 None
 1.22A 4g10A-3tqpA:
undetectable		 4g10A-3tqpA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)		 3tqp ENOLASE
(Coxiella
burnetii) 		3 / 3 ILE A 284
MET A 268
ARG A 271
 None
 0.93A 4lnwA-3tqpA:
undetectable		 4lnwA-3tqpA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_2
(THYROID HORMONE
RECEPTOR ALPHA)		 3tqp ENOLASE
(Coxiella
burnetii) 		3 / 3 ILE A 284
MET A 268
ARG A 271
 None
 0.95A 4lnxA-3tqpA:
undetectable		 4lnxA-3tqpA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 3tqp ENOLASE
(Coxiella
burnetii) 		5 / 12 ALA A  68
GLY A 114
LEU A 338
ILE A 341
THR A 317
 None
 1.17A 4n48B-3tqpA:
undetectable		 4n48B-3tqpA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0B_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 3tqp ENOLASE
(Coxiella
burnetii) 		4 / 8 VAL A  38
VAL A  24
TYR A 121
LEU A 338
 None
 1.18A 4q0bA-3tqpA:
undetectable		 4q0bA-3tqpA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0P_A_TE4A201_1
(BETA-LACTOGLOBULIN)		 3tqp ENOLASE
(Coxiella
burnetii) 		5 / 12 LEU A 191
ILE A 151
ILE A 169
ILE A 228
LEU A 214
 None
 1.09A 4y0pA-3tqpA:
undetectable		 4y0pA-3tqpA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 3tqp ENOLASE
(Coxiella
burnetii) 		5 / 12 THR A 347
GLY A 342
LEU A 338
GLU A 166
LEU A 335
 None
None
None
MG  A 430 ( 4.7A)
None
 0.98A 5c0oG-3tqpA:
undetectable		 5c0oG-3tqpA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_D_QELD503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 3tqp ENOLASE
(Coxiella
burnetii) 		5 / 12 TYR A 183
LEU A 392
ALA A 178
THR A 389
PRO A 147
 None
 1.44A 5ewjC-3tqpA:
undetectable
5ewjD-3tqpA:
2.0		 5ewjC-3tqpA:
23.50
5ewjD-3tqpA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_1
(CYTOCHROME P450 3A4)		 3tqp ENOLASE
(Coxiella
burnetii) 		5 / 12 ILE A 363
ALA A 422
ILE A 282
ALA A 242
GLU A 166
 None
None
None
None
MG  A 430 ( 4.7A)
 1.11A 5vceA-3tqpA:
2.1		 5vceA-3tqpA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 3tqp ENOLASE
(Coxiella
burnetii) 		5 / 12 MET A 144
LEU A 404
ILE A 375
THR A 347
VAL A 351
 None
 1.18A 6djzA-3tqpA:
undetectable		 6djzA-3tqpA:
20.80