SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tqv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSG_B_MK1B902_1
(HIV-1 PROTEASE)		 3tqv NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Francisella
tularensis) 		5 / 10 LEU A 138
VAL A 247
ILE A 232
VAL A 269
ILE A 267
 None
 0.94A 1hsgA-3tqvA:
undetectable		 1hsgA-3tqvA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_3
(HIV-1 PROTEASE)		 3tqv NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Francisella
tularensis) 		5 / 12 LEU A 138
ALA A 260
ILE A 232
VAL A 269
ILE A 267
 None
 1.07A 1hxbB-3tqvA:
undetectable		 1hxbB-3tqvA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_3
(HIV-1 PROTEASE)		 3tqv NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Francisella
tularensis) 		5 / 12 LEU A 138
VAL A 247
ILE A 232
VAL A 269
ILE A 267
 None
 0.91A 1hxbB-3tqvA:
undetectable		 1hxbB-3tqvA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_2
(ASPARTYLPROTEASE)		 3tqv NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Francisella
tularensis) 		5 / 9 LEU A 138
VAL A 247
ILE A 232
VAL A 269
ILE A 267
 None
 0.97A 1ohrB-3tqvA:
undetectable		 1ohrB-3tqvA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK2_A_ACAA91_1
(TISSUE-TYPE
PLASMINOGEN
ACTIVATOR)		 3tqv NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Francisella
tularensis) 		4 / 8 VAL A  14
TYR A 154
ASP A  83
LEU A  22
 None
 0.93A 1pk2A-3tqvA:
undetectable		 1pk2A-3tqvA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1200_1
(SERUM ALBUMIN)		 3tqv NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Francisella
tularensis) 		4 / 4 LEU A 138
ILE A 251
ILE A 259
ALA A 260
 None
 0.85A 2i30A-3tqvA:
undetectable		 2i30A-3tqvA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_NCAA493_0
(CHORISMATE SYNTHASE)		 3tqv NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Francisella
tularensis) 		5 / 11 ALA A 188
ILE A 185
ALA A 217
ALA A 219
VAL A 201
 None
 1.17A 2qhfA-3tqvA:
undetectable		 2qhfA-3tqvA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_A_SALA305_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 3tqv NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Francisella
tularensis) 		4 / 7 VAL A 264
ILE A 267
ILE A 251
SER A 255
 None
 0.83A 3deuA-3tqvA:
undetectable		 3deuA-3tqvA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MWS_B_017B201_2
(HIV-1 PROTEASE)		 3tqv NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Francisella
tularensis) 		5 / 12 LEU A 138
VAL A 247
ILE A 232
VAL A 269
ILE A 267
 None
 0.99A 3mwsB-3tqvA:
undetectable		 3mwsB-3tqvA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_1
(PROTEASE)		 3tqv NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Francisella
tularensis) 		5 / 12 LEU A 138
VAL A 247
ILE A 232
VAL A 269
ILE A 267
 None
 0.93A 3nduC-3tqvA:
undetectable		 3nduC-3tqvA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QGI_A_ROCA101_2
(PROTEASE)		 3tqv NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Francisella
tularensis) 		5 / 11 LEU A 138
VAL A 247
ILE A 232
VAL A 269
ILE A 267
 None
 0.94A 4qgiB-3tqvA:
undetectable		 4qgiB-3tqvA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_1
(HYDG PROTEIN)		 3tqv NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Francisella
tularensis) 		3 / 3 GLU A 107
ARG A 108
GLN A 284
 None
 0.96A 4rtbA-3tqvA:
2.5		 4rtbA-3tqvA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 3tqv NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Francisella
tularensis) 		5 / 10 LEU A 104
ALA A 106
LEU A  71
GLY A  98
LEU A  96
 None
 1.34A 5dxbA-3tqvA:
undetectable		 5dxbA-3tqvA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_B_SAMB801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 3tqv NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Francisella
tularensis) 		5 / 11 ILE A 185
ASP A 209
ALA A 214
PHE A 227
VAL A 222
 None
 1.23A 5hw4B-3tqvA:
undetectable		 5hw4B-3tqvA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_C_SAMC801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 3tqv NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Francisella
tularensis) 		5 / 12 ILE A 185
ASP A 209
ALA A 214
PHE A 227
VAL A 222
 None
 1.23A 5hw4C-3tqvA:
undetectable		 5hw4C-3tqvA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_A_ROCA101_2
(PROTEASE PR5-SQV)		 3tqv NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Francisella
tularensis) 		5 / 11 LEU A 138
ALA A 260
ILE A 232
VAL A 269
ILE A 267
 None
 1.26A 5kr2B-3tqvA:
undetectable		 5kr2B-3tqvA:
17.67