SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tr0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3tr0 GUANYLATE KINASE
(Coxiella
burnetii) 		5 / 11 ILE A 178
VAL A 174
ALA A 173
PHE A 170
ILE A 121
 None
 0.99A 1uduA-3tr0A:
undetectable		 1uduA-3tr0A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 3tr0 GUANYLATE KINASE
(Coxiella
burnetii) 		3 / 3 ALA A 173
ASN A 176
LEU A 177
 None
 0.42A 5i1oC-3tr0A:
undetectable		 5i1oC-3tr0A:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_H_DVAH9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 3tr0 GUANYLATE KINASE
(Coxiella
burnetii) 		3 / 3 ALA A 173
ASN A 176
LEU A 177
 None
 0.48A 5i1oA-3tr0A:
undetectable		 5i1oA-3tr0A:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 3tr0 GUANYLATE KINASE
(Coxiella
burnetii) 		3 / 3 ALA A 173
ASN A 176
LEU A 177
 None
 0.37A 5i1pA-3tr0A:
undetectable		 5i1pA-3tr0A:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 3tr0 GUANYLATE KINASE
(Coxiella
burnetii) 		3 / 3 ALA A 173
ASN A 176
LEU A 177
 None
 0.45A 5i1pD-3tr0A:
undetectable		 5i1pD-3tr0A:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_E_LLLE301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3tr0 GUANYLATE KINASE
(Coxiella
burnetii) 		4 / 7 ARG A  78
TYR A  76
GLU A  77
GLU A  57
 None
 1.35A 6mn5E-3tr0A:
undetectable		 6mn5E-3tr0A:
16.18