SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tr1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Coxiella
burnetii) 		3 / 3 GLN A 169
ILE A 228
HIS A 203
 PO4  A 442 ( 4.1A)
None
None
 0.56A 1fm9A-3tr1A:
undetectable		 1fm9A-3tr1A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Coxiella
burnetii) 		5 / 10 LEU A  29
LEU A 176
THR A 197
PHE A  43
ILE A  23
 None
 1.33A 1i18A-3tr1A:
undetectable
1i18B-3tr1A:
undetectable		 1i18A-3tr1A:
12.10
1i18B-3tr1A:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Coxiella
burnetii) 		3 / 3 GLN A 169
ILE A 228
HIS A 203
 PO4  A 442 ( 4.1A)
None
None
 0.51A 1k74A-3tr1A:
undetectable		 1k74A-3tr1A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_1
(GLYCINE
N-METHYLTRANSFERASE)		 3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Coxiella
burnetii) 		4 / 6 ASP A 233
SER A 235
ASN A 260
SER A  24
 None
 1.48A 1kiaC-3tr1A:
undetectable		 1kiaC-3tr1A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Coxiella
burnetii) 		4 / 4 ALA A  31
VAL A  28
ALA A  27
HIS A 203
 None
 1.01A 1q23A-3tr1A:
undetectable		 1q23A-3tr1A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Coxiella
burnetii) 		4 / 4 ALA A  31
VAL A  28
ALA A  27
HIS A 203
 None
 1.07A 1q23F-3tr1A:
undetectable		 1q23F-3tr1A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Coxiella
burnetii) 		4 / 4 ALA A  31
VAL A  28
ALA A  27
HIS A 203
 None
 1.08A 1q23K-3tr1A:
undetectable		 1q23K-3tr1A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_B_DESB128_1
(TRANSTHYRETIN)		 3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Coxiella
burnetii) 		5 / 11 LEU A 114
ALA A  97
LEU A  89
LEU A  29
LEU A  56
 None
 1.29A 1tz8A-3tr1A:
undetectable
1tz8B-3tr1A:
undetectable		 1tz8A-3tr1A:
16.67
1tz8B-3tr1A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V3Q_E_2DIE290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Coxiella
burnetii) 		5 / 10 GLY A  76
VAL A  77
GLY A  78
MET A  79
THR A  38
 None
 1.32A 1v3qE-3tr1A:
undetectable		 1v3qE-3tr1A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Coxiella
burnetii) 		4 / 5 LEU A 254
PRO A  18
VAL A  17
ILE A  15
 None
 0.89A 2aoiB-3tr1A:
undetectable		 2aoiB-3tr1A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Coxiella
burnetii) 		5 / 10 LEU A 105
GLY A 103
LEU A 101
ILE A  98
ILE A 150
 None
 1.08A 2f8dA-3tr1A:
undetectable		 2f8dA-3tr1A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_B_BEZB1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Coxiella
burnetii) 		5 / 10 LEU A 105
GLY A 103
LEU A 101
ILE A  98
ILE A 150
 None
 1.08A 2f8dB-3tr1A:
undetectable		 2f8dB-3tr1A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA801_1
(TRANSPORTER)		 3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Coxiella
burnetii) 		5 / 11 VAL A 394
ILE A  15
PHE A 415
ALA A 243
LEU A 254
 None
 1.17A 2q72A-3tr1A:
undetectable		 2q72A-3tr1A:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_2
(CYTOCHROME P450 2R1)		 3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Coxiella
burnetii) 		3 / 3 LEU A 357
GLU A 379
ILE A 405
 None
 0.58A 3czhA-3tr1A:
undetectable		 3czhA-3tr1A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		 3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Coxiella
burnetii) 		4 / 5 TYR A 151
ALA A  84
ALA A 106
TYR A 180
 None
 1.08A 3d91A-3tr1A:
undetectable		 3d91A-3tr1A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_B_ADNB438_2
(ADENOSYLHOMOCYSTEINA
SE)		 3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Coxiella
burnetii) 		3 / 3 THR A 290
GLU A 288
HIS A 203
 None
 0.76A 3g1uB-3tr1A:
undetectable		 3g1uB-3tr1A:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_0
(PCZA361.24)		 3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Coxiella
burnetii) 		5 / 12 ALA A 177
GLY A 103
LEU A 179
LEU A 175
SER A 172
 None
None
None
None
PO4  A 441 (-2.8A)
 1.09A 3g2oA-3tr1A:
undetectable		 3g2oA-3tr1A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_2
(FIV PROTEASE)		 3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Coxiella
burnetii) 		5 / 10 ILE A 228
VAL A  40
GLY A  19
VAL A  65
LEU A  72
 None
 1.28A 3ogpB-3tr1A:
undetectable		 3ogpB-3tr1A:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_3
(NS3 PROTEASE, NS4A
PROTEIN)		 3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Coxiella
burnetii) 		4 / 5 SER A 119
ARG A 123
PRO A 124
VAL A 145
 None
PO4  A 440 (-2.9A)
PO4  A 443 (-4.4A)
None
 1.22A 3sufC-3tr1A:
undetectable		 3sufC-3tr1A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_C_ADNC251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Coxiella
burnetii) 		5 / 12 HIS A 196
ARG A 194
ARG A 387
GLY A  19
GLU A 316
 PO4  A 442 ( 4.9A)
PO4  A 442 ( 3.4A)
PO4  A 439 (-3.8A)
None
None
 1.39A 3u40B-3tr1A:
undetectable
3u40C-3tr1A:
undetectable		 3u40B-3tr1A:
21.71
3u40C-3tr1A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_E_ADNE251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Coxiella
burnetii) 		5 / 12 HIS A 196
ARG A 194
ARG A 387
GLY A  19
GLU A 316
 PO4  A 442 ( 4.9A)
PO4  A 442 ( 3.4A)
PO4  A 439 (-3.8A)
None
None
 1.41A 3u40D-3tr1A:
undetectable
3u40E-3tr1A:
undetectable		 3u40D-3tr1A:
21.71
3u40E-3tr1A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UWL_B_FOZB316_0
(THYMIDYLATE SYNTHASE)		 3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Coxiella
burnetii) 		6 / 12 LEU A 421
ILE A  15
LEU A  11
GLY A 426
ILE A 252
ALA A 251
 None
 1.33A 3uwlB-3tr1A:
undetectable		 3uwlB-3tr1A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Coxiella
burnetii) 		5 / 9 THR A 397
ALA A 422
ILE A  15
ALA A 244
ILE A 252
 None
 1.03A 4lbgB-3tr1A:
undetectable		 4lbgB-3tr1A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Coxiella
burnetii) 		3 / 3 LEU A 148
ILE A  98
ARG A  99
 None
 0.64A 4mk4B-3tr1A:
undetectable		 4mk4B-3tr1A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCU_B_SAMB603_0
(CYSTATHIONINE
BETA-SYNTHASE)		 3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Coxiella
burnetii) 		5 / 9 LEU A 339
PHE A 317
VAL A 368
THR A 331
ILE A 303
 None
 1.08A 4pcuA-3tr1A:
undetectable
4pcuB-3tr1A:
undetectable		 4pcuA-3tr1A:
22.35
4pcuB-3tr1A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Coxiella
burnetii) 		3 / 3 ASP A 233
ARG A 123
ARG A 346
 None
PO4  A 440 (-2.9A)
PO4  A 439 (-2.6A)
 0.97A 4x5iA-3tr1A:
undetectable		 4x5iA-3tr1A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_N_TRPN101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Coxiella
burnetii) 		5 / 9 HIS A  25
THR A 197
HIS A 196
THR A  96
SER A 172
 None
None
PO4  A 442 ( 4.9A)
PO4  A 440 (-3.5A)
PO4  A 441 (-2.8A)
 1.39A 5eevM-3tr1A:
undetectable
5eevN-3tr1A:
undetectable		 5eevM-3tr1A:
10.12
5eevN-3tr1A:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Coxiella
burnetii) 		5 / 10 HIS A  25
THR A 197
HIS A 196
THR A  96
SER A 172
 None
None
PO4  A 442 ( 4.9A)
PO4  A 440 (-3.5A)
PO4  A 441 (-2.8A)
 1.37A 5eevU-3tr1A:
undetectable
5eevV-3tr1A:
undetectable		 5eevU-3tr1A:
10.12
5eevV-3tr1A:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_N_TRPN101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Coxiella
burnetii) 		5 / 9 HIS A  25
THR A 197
HIS A 196
THR A  96
SER A 172
 None
None
PO4  A 442 ( 4.9A)
PO4  A 440 (-3.5A)
PO4  A 441 (-2.8A)
 1.39A 5eewM-3tr1A:
undetectable
5eewN-3tr1A:
undetectable		 5eewM-3tr1A:
10.12
5eewN-3tr1A:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Coxiella
burnetii) 		5 / 10 HIS A  25
THR A 197
HIS A 196
THR A  96
SER A 172
 None
None
PO4  A 442 ( 4.9A)
PO4  A 440 (-3.5A)
PO4  A 441 (-2.8A)
 1.37A 5eewU-3tr1A:
undetectable
5eewV-3tr1A:
undetectable		 5eewU-3tr1A:
10.12
5eewV-3tr1A:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_N_TRPN101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Coxiella
burnetii) 		5 / 9 HIS A  25
THR A 197
HIS A 196
THR A  96
SER A 172
 None
None
PO4  A 442 ( 4.9A)
PO4  A 440 (-3.5A)
PO4  A 441 (-2.8A)
 1.39A 5eexM-3tr1A:
undetectable
5eexN-3tr1A:
undetectable		 5eexM-3tr1A:
10.12
5eexN-3tr1A:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Coxiella
burnetii) 		5 / 9 HIS A  25
THR A 197
HIS A 196
THR A  96
SER A 172
 None
None
PO4  A 442 ( 4.9A)
PO4  A 440 (-3.5A)
PO4  A 441 (-2.8A)
 1.35A 5eexQ-3tr1A:
undetectable
5eexR-3tr1A:
undetectable		 5eexQ-3tr1A:
10.12
5eexR-3tr1A:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Coxiella
burnetii) 		5 / 10 HIS A  25
THR A 197
HIS A 196
THR A  96
SER A 172
 None
None
PO4  A 442 ( 4.9A)
PO4  A 440 (-3.5A)
PO4  A 441 (-2.8A)
 1.37A 5eexU-3tr1A:
undetectable
5eexV-3tr1A:
undetectable		 5eexU-3tr1A:
10.12
5eexV-3tr1A:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_N_TRPN101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Coxiella
burnetii) 		5 / 9 HIS A  25
THR A 197
HIS A 196
THR A  96
SER A 172
 None
None
PO4  A 442 ( 4.9A)
PO4  A 440 (-3.5A)
PO4  A 441 (-2.8A)
 1.39A 5eeyM-3tr1A:
undetectable
5eeyN-3tr1A:
undetectable		 5eeyM-3tr1A:
10.12
5eeyN-3tr1A:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Coxiella
burnetii) 		5 / 9 HIS A  25
THR A 197
HIS A 196
THR A  96
SER A 172
 None
None
PO4  A 442 ( 4.9A)
PO4  A 440 (-3.5A)
PO4  A 441 (-2.8A)
 1.35A 5eeyQ-3tr1A:
undetectable
5eeyR-3tr1A:
undetectable		 5eeyQ-3tr1A:
10.12
5eeyR-3tr1A:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Coxiella
burnetii) 		5 / 10 HIS A  25
THR A 197
HIS A 196
THR A  96
SER A 172
 None
None
PO4  A 442 ( 4.9A)
PO4  A 440 (-3.5A)
PO4  A 441 (-2.8A)
 1.37A 5eeyU-3tr1A:
undetectable
5eeyV-3tr1A:
undetectable		 5eeyU-3tr1A:
10.12
5eeyV-3tr1A:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_N_TRPN101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Coxiella
burnetii) 		5 / 9 HIS A  25
THR A 197
HIS A 196
THR A  96
SER A 172
 None
None
PO4  A 442 ( 4.9A)
PO4  A 440 (-3.5A)
PO4  A 441 (-2.8A)
 1.39A 5eezM-3tr1A:
undetectable
5eezN-3tr1A:
undetectable		 5eezM-3tr1A:
10.12
5eezN-3tr1A:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Coxiella
burnetii) 		5 / 9 HIS A  25
THR A 197
HIS A 196
THR A  96
SER A 172
 None
None
PO4  A 442 ( 4.9A)
PO4  A 440 (-3.5A)
PO4  A 441 (-2.8A)
 1.35A 5eezQ-3tr1A:
undetectable
5eezR-3tr1A:
undetectable		 5eezQ-3tr1A:
10.12
5eezR-3tr1A:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Coxiella
burnetii) 		5 / 10 HIS A  25
THR A 197
HIS A 196
THR A  96
SER A 172
 None
None
PO4  A 442 ( 4.9A)
PO4  A 440 (-3.5A)
PO4  A 441 (-2.8A)
 1.37A 5eezU-3tr1A:
undetectable
5eezV-3tr1A:
undetectable		 5eezU-3tr1A:
10.12
5eezV-3tr1A:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_N_TRPN101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Coxiella
burnetii) 		5 / 9 HIS A  25
THR A 197
HIS A 196
THR A  96
SER A 172
 None
None
PO4  A 442 ( 4.9A)
PO4  A 440 (-3.5A)
PO4  A 441 (-2.8A)
 1.39A 5ef0M-3tr1A:
undetectable
5ef0N-3tr1A:
undetectable		 5ef0M-3tr1A:
10.12
5ef0N-3tr1A:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Coxiella
burnetii) 		5 / 9 HIS A  25
THR A 197
HIS A 196
THR A  96
SER A 172
 None
None
PO4  A 442 ( 4.9A)
PO4  A 440 (-3.5A)
PO4  A 441 (-2.8A)
 1.35A 5ef0Q-3tr1A:
undetectable
5ef0R-3tr1A:
undetectable		 5ef0Q-3tr1A:
10.12
5ef0R-3tr1A:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Coxiella
burnetii) 		5 / 10 HIS A  25
THR A 197
HIS A 196
THR A  96
SER A 172
 None
None
PO4  A 442 ( 4.9A)
PO4  A 440 (-3.5A)
PO4  A 441 (-2.8A)
 1.37A 5ef0U-3tr1A:
undetectable
5ef0V-3tr1A:
undetectable		 5ef0U-3tr1A:
10.12
5ef0V-3tr1A:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_N_TRPN101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Coxiella
burnetii) 		5 / 9 HIS A  25
THR A 197
HIS A 196
THR A  96
SER A 172
 None
None
PO4  A 442 ( 4.9A)
PO4  A 440 (-3.5A)
PO4  A 441 (-2.8A)
 1.39A 5ef1M-3tr1A:
undetectable
5ef1N-3tr1A:
undetectable		 5ef1M-3tr1A:
10.12
5ef1N-3tr1A:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Coxiella
burnetii) 		5 / 9 HIS A  25
THR A 197
HIS A 196
THR A  96
SER A 172
 None
None
PO4  A 442 ( 4.9A)
PO4  A 440 (-3.5A)
PO4  A 441 (-2.8A)
 1.35A 5ef1Q-3tr1A:
undetectable
5ef1R-3tr1A:
undetectable		 5ef1Q-3tr1A:
10.12
5ef1R-3tr1A:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Coxiella
burnetii) 		5 / 10 HIS A  25
THR A 197
HIS A 196
THR A  96
SER A 172
 None
None
PO4  A 442 ( 4.9A)
PO4  A 440 (-3.5A)
PO4  A 441 (-2.8A)
 1.37A 5ef1U-3tr1A:
undetectable
5ef1V-3tr1A:
undetectable		 5ef1U-3tr1A:
10.12
5ef1V-3tr1A:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_N_TRPN101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Coxiella
burnetii) 		5 / 9 HIS A  25
THR A 197
HIS A 196
THR A  96
SER A 172
 None
None
PO4  A 442 ( 4.9A)
PO4  A 440 (-3.5A)
PO4  A 441 (-2.8A)
 1.39A 5ef2M-3tr1A:
undetectable
5ef2N-3tr1A:
undetectable		 5ef2M-3tr1A:
10.12
5ef2N-3tr1A:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Coxiella
burnetii) 		5 / 9 HIS A  25
THR A 197
HIS A 196
THR A  96
SER A 172
 None
None
PO4  A 442 ( 4.9A)
PO4  A 440 (-3.5A)
PO4  A 441 (-2.8A)
 1.35A 5ef2Q-3tr1A:
undetectable
5ef2R-3tr1A:
undetectable		 5ef2Q-3tr1A:
10.12
5ef2R-3tr1A:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Coxiella
burnetii) 		5 / 10 HIS A  25
THR A 197
HIS A 196
THR A  96
SER A 172
 None
None
PO4  A 442 ( 4.9A)
PO4  A 440 (-3.5A)
PO4  A 441 (-2.8A)
 1.37A 5ef2U-3tr1A:
undetectable
5ef2V-3tr1A:
undetectable		 5ef2U-3tr1A:
10.12
5ef2V-3tr1A:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_N_TRPN101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Coxiella
burnetii) 		5 / 9 HIS A  25
THR A 197
HIS A 196
THR A  96
SER A 172
 None
None
PO4  A 442 ( 4.9A)
PO4  A 440 (-3.5A)
PO4  A 441 (-2.8A)
 1.39A 5ef3M-3tr1A:
undetectable
5ef3N-3tr1A:
undetectable		 5ef3M-3tr1A:
10.12
5ef3N-3tr1A:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Coxiella
burnetii) 		5 / 9 HIS A  25
THR A 197
HIS A 196
THR A  96
SER A 172
 None
None
PO4  A 442 ( 4.9A)
PO4  A 440 (-3.5A)
PO4  A 441 (-2.8A)
 1.35A 5ef3Q-3tr1A:
undetectable
5ef3R-3tr1A:
undetectable		 5ef3Q-3tr1A:
10.12
5ef3R-3tr1A:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Coxiella
burnetii) 		5 / 10 HIS A  25
THR A 197
HIS A 196
THR A  96
SER A 172
 None
None
PO4  A 442 ( 4.9A)
PO4  A 440 (-3.5A)
PO4  A 441 (-2.8A)
 1.37A 5ef3U-3tr1A:
undetectable
5ef3V-3tr1A:
undetectable		 5ef3U-3tr1A:
10.12
5ef3V-3tr1A:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GSN_A_MMZA503_1
(FLAVIN-CONTAINING
MONOOXYGENASE)		 3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Coxiella
burnetii) 		3 / 3 ASN A  93
SER A 119
SER A 118
 K  A 444 ( 3.7A)
None
None
 0.63A 5gsnA-3tr1A:
undetectable		 5gsnA-3tr1A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Coxiella
burnetii) 		3 / 3 VAL A  65
LEU A  82
MET A  59
 None
 0.64A 5ikrA-3tr1A:
0.3		 5ikrA-3tr1A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Coxiella
burnetii) 		3 / 3 VAL A 279
LEU A 300
MET A 273
 None
 0.80A 5ikrA-3tr1A:
0.3		 5ikrA-3tr1A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNW_D_GCSD302_1
(25 KDA PROTEIN
ELICITOR)		 3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Coxiella
burnetii) 		4 / 7 ASP A 233
GLY A 232
HIS A 196
ASP A  20
 None
None
PO4  A 442 ( 4.9A)
None
 1.05A 5nnwD-3tr1A:
undetectable		 5nnwD-3tr1A:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NO9_D_95ZD302_1
(25 KDA PROTEIN
ELICITOR)		 3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Coxiella
burnetii) 		4 / 7 ASP A 233
GLY A 232
HIS A 196
ASP A  20
 None
None
PO4  A 442 ( 4.9A)
None
 1.07A 5no9D-3tr1A:
undetectable		 5no9D-3tr1A:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_E_SAME501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Coxiella
burnetii) 		5 / 9 LEU A 105
PRO A  85
GLY A 152
VAL A 113
LEU A 114
 None
 1.48A 5o96E-3tr1A:
undetectable
5o96F-3tr1A:
undetectable		 5o96E-3tr1A:
20.31
5o96F-3tr1A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGG_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Coxiella
burnetii) 		4 / 4 VAL A 419
VAL A 429
TYR A   3
GLN A   4
 None
 1.47A 5qggA-3tr1A:
undetectable		 5qggA-3tr1A:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGO_A_ACTA302_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Coxiella
burnetii) 		4 / 4 VAL A 419
VAL A 429
TYR A   3
GLN A   4
 None
 1.42A 5qgoA-3tr1A:
undetectable		 5qgoA-3tr1A:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGP_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Coxiella
burnetii) 		4 / 4 VAL A 419
VAL A 429
TYR A   3
GLN A   4
 None
 1.39A 5qgpA-3tr1A:
undetectable		 5qgpA-3tr1A:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGQ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Coxiella
burnetii) 		4 / 4 VAL A 419
VAL A 429
TYR A   3
GLN A   4
 None
 1.44A 5qgqA-3tr1A:
undetectable		 5qgqA-3tr1A:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHB_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Coxiella
burnetii) 		4 / 4 VAL A 419
VAL A 429
TYR A   3
GLN A   4
 None
 1.43A 5qhbA-3tr1A:
undetectable		 5qhbA-3tr1A:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAH_C_RFPC3001_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Coxiella
burnetii) 		5 / 12 LEU A 132
ARG A  99
SER A 102
LEU A 148
ILE A  98
 None
 1.46A 5uahC-3tr1A:
undetectable		 5uahC-3tr1A:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Coxiella
burnetii) 		4 / 5 HIS A  25
ASP A 233
GLY A  19
ASN A  49
 None
 1.43A 5x7pB-3tr1A:
undetectable		 5x7pB-3tr1A:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Coxiella
burnetii) 		4 / 8 GLU A 198
SER A 102
MET A  52
LEU A 120
 None
 1.06A 5y2tB-3tr1A:
undetectable		 5y2tB-3tr1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Coxiella
burnetii) 		3 / 3 GLN A 169
ILE A 228
HIS A 203
 PO4  A 442 ( 4.1A)
None
None
 0.52A 5z12B-3tr1A:
undetectable		 5z12B-3tr1A:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9H_R_ADNR400_1
(CHIMERA PROTEIN OF
MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4 AND
ADENOSINE RECEPTOR
A1)		 3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Coxiella
burnetii) 		5 / 10 VAL A 394
GLU A 316
LEU A 270
ILE A 241
THR A 245
 None
 1.14A 6d9hR-3tr1A:
undetectable		 6d9hR-3tr1A:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F8C_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Coxiella
burnetii) 		4 / 6 ALA A 275
GLY A 265
THR A 313
ILE A 305
 None
 0.89A 6f8cA-3tr1A:
undetectable		 6f8cA-3tr1A:
10.27