SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tr2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3003_1
(SERUM ALBUMIN)		 3tr2 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Coxiella
burnetii) 		4 / 6 HIS A  90
ILE A  89
ALA A 153
VAL A 101
 None
 0.98A 1hk1A-3tr2A:
undetectable		 1hk1A-3tr2A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_A_SAMA3142_1
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 3tr2 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Coxiella
burnetii) 		4 / 4 HIS A  33
ASP A 208
ASN A 175
ASP A   5
 None
 1.43A 1wg8A-3tr2A:
undetectable		 1wg8A-3tr2A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3tr2 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Coxiella
burnetii) 		4 / 8 ALA A 202
ASP A 230
ILE A 229
ILE A 216
 None
 0.89A 4kttB-3tr2A:
undetectable		 4kttB-3tr2A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3tr2 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Coxiella
burnetii) 		4 / 8 ALA A 202
ASP A 230
ILE A 229
ILE A 216
 None
 0.89A 4kttD-3tr2A:
undetectable		 4kttD-3tr2A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3tr2 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Coxiella
burnetii) 		4 / 8 ALA A 202
ASP A 230
ILE A 229
ILE A 216
 None
 0.93A 4ndnB-3tr2A:
undetectable		 4ndnB-3tr2A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3tr2 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Coxiella
burnetii) 		4 / 8 ALA A 202
ASP A 230
ILE A 229
ILE A 216
 None
 0.96A 4ndnD-3tr2A:
undetectable		 4ndnD-3tr2A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QC6_B_KANB201_2
(BIFUNCTIONAL AAC/APH)		 3tr2 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Coxiella
burnetii) 		3 / 3 LEU A 177
ASP A 208
TYR A 209
 None
 0.61A 4qc6B-3tr2A:
undetectable		 4qc6B-3tr2A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0I_B_ACTB303_0
(SWI5-DEPENDENT HO
EXPRESSION PROTEIN 2)		 3tr2 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Coxiella
burnetii) 		4 / 5 VAL A  79
ASN A  88
ASP A  62
LEU A  63
 None
 1.13A 5m0iB-3tr2A:
undetectable		 5m0iB-3tr2A:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH8_A_ACTA302_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3tr2 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Coxiella
burnetii) 		3 / 3 CYH A  76
MET A  87
ASN A  88
 None
 0.90A 5qh8A-3tr2A:
undetectable		 5qh8A-3tr2A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 3tr2 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Coxiella
burnetii) 		4 / 8 ALA A 202
ASP A 230
ILE A 229
ILE A 216
 None
 0.96A 5t8sA-3tr2A:
undetectable		 5t8sA-3tr2A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DYO_A_LDPA901_0
(EBONY)		 3tr2 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Coxiella
burnetii) 		4 / 5 GLU A 164
VAL A 143
HIS A  90
THR A 123
 None
 1.45A 6dyoA-3tr2A:
undetectable		 6dyoA-3tr2A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_C_SAMC301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 3tr2 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Coxiella
burnetii) 		5 / 12 LEU A  34
ILE A  59
ILE A  12
ASP A  62
ILE A  36
 None
 1.05A 6emuC-3tr2A:
undetectable		 6emuC-3tr2A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3tr2 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Coxiella
burnetii) 		4 / 7 ALA A 202
ASP A 230
ILE A 229
ILE A 216
 None
 0.92A 6fbnA-3tr2A:
undetectable		 6fbnA-3tr2A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNA_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 3tr2 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Coxiella
burnetii) 		3 / 3 ARG A  58
LYS A   5
TYR A 209
 None
 1.10A 6gnaA-3tr2A:
undetectable		 6gnaA-3tr2A:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNB_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 3tr2 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Coxiella
burnetii) 		3 / 3 ARG A  58
LYS A   5
TYR A 209
 None
 1.10A 6gnbA-3tr2A:
undetectable		 6gnbA-3tr2A:
24.84