SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tr4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_A_FOLA605_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3tr4 INORGANIC
PYROPHOSPHATASE
(Coxiella
burnetii) 		5 / 12 VAL A 107
ALA A  88
LEU A 122
ILE A 133
LEU A 129
 None
 0.98A 1qzfA-3tr4A:
undetectable		 1qzfA-3tr4A:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_B_FOLB609_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3tr4 INORGANIC
PYROPHOSPHATASE
(Coxiella
burnetii) 		5 / 12 VAL A 107
ALA A  88
LEU A 122
ILE A 133
LEU A 129
 None
 0.99A 1qzfB-3tr4A:
undetectable		 1qzfB-3tr4A:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_C_FOLC613_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3tr4 INORGANIC
PYROPHOSPHATASE
(Coxiella
burnetii) 		5 / 12 VAL A 107
ALA A  88
LEU A 122
ILE A 133
LEU A 129
 None
 0.99A 1qzfC-3tr4A:
undetectable		 1qzfC-3tr4A:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_D_FOLD617_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3tr4 INORGANIC
PYROPHOSPHATASE
(Coxiella
burnetii) 		5 / 12 VAL A 107
ALA A  88
LEU A 122
ILE A 133
LEU A 129
 None
 0.99A 1qzfD-3tr4A:
undetectable		 1qzfD-3tr4A:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_E_FOLE621_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3tr4 INORGANIC
PYROPHOSPHATASE
(Coxiella
burnetii) 		5 / 12 VAL A 107
ALA A  88
LEU A 122
ILE A 133
LEU A 129
 None
 1.00A 1qzfE-3tr4A:
undetectable		 1qzfE-3tr4A:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3tr4 INORGANIC
PYROPHOSPHATASE
(Coxiella
burnetii) 		5 / 12 VAL A 107
ALA A  88
LEU A 122
ILE A 133
LEU A 129
 None
 0.93A 2oipA-3tr4A:
undetectable		 2oipA-3tr4A:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0I_A_BEZA990_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 3tr4 INORGANIC
PYROPHOSPHATASE
(Coxiella
burnetii) 		4 / 8 ASP A  64
ASP A  69
GLU A 163
LEU A  68
 MN  A 176 (-3.2A)
MN  A 176 (-2.5A)
None
None
 1.12A 2q0iA-3tr4A:
undetectable		 2q0iA-3tr4A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEO_A_LNRA200_1
(D7R4 PROTEIN)		 3tr4 INORGANIC
PYROPHOSPHATASE
(Coxiella
burnetii) 		5 / 12 GLU A  30
ILE A  20
TYR A  50
ASP A  96
ASP A  64
 None
None
None
None
MN  A 176 (-3.2A)
 1.48A 2qeoA-3tr4A:
undetectable		 2qeoA-3tr4A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3tr4 INORGANIC
PYROPHOSPHATASE
(Coxiella
burnetii) 		4 / 8 TYR A 140
TYR A  50
CYH A  52
ILE A 133
 None
 0.93A 2xz5B-3tr4A:
undetectable
2xz5E-3tr4A:
undetectable		 2xz5B-3tr4A:
25.00
2xz5E-3tr4A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3tr4 INORGANIC
PYROPHOSPHATASE
(Coxiella
burnetii) 		4 / 8 ILE A 133
TYR A 140
TYR A  50
CYH A  52
 None
 0.86A 2xz5A-3tr4A:
undetectable
2xz5C-3tr4A:
undetectable		 2xz5A-3tr4A:
25.00
2xz5C-3tr4A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3tr4 INORGANIC
PYROPHOSPHATASE
(Coxiella
burnetii) 		4 / 8 ILE A 133
TYR A 140
TYR A  50
CYH A  52
 None
 0.86A 2xz5C-3tr4A:
undetectable
2xz5D-3tr4A:
undetectable		 2xz5C-3tr4A:
25.00
2xz5D-3tr4A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3tr4 INORGANIC
PYROPHOSPHATASE
(Coxiella
burnetii) 		4 / 7 ILE A 133
TYR A 140
TYR A  50
CYH A  52
 None
 0.86A 2xz5D-3tr4A:
undetectable
2xz5E-3tr4A:
undetectable		 2xz5D-3tr4A:
25.00
2xz5E-3tr4A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 3tr4 INORGANIC
PYROPHOSPHATASE
(Coxiella
burnetii) 		5 / 12 VAL A  78
GLU A  19
ILE A  20
LEU A  71
VAL A  86
 None
 1.13A 3fpjB-3tr4A:
undetectable		 3fpjB-3tr4A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFT_D_QMRD301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3tr4 INORGANIC
PYROPHOSPHATASE
(Coxiella
burnetii) 		4 / 8 TYR A 140
TYR A  50
CYH A  52
ILE A 133
 None
 0.90A 4aftD-3tr4A:
undetectable
4aftE-3tr4A:
undetectable		 4aftD-3tr4A:
25.00
4aftE-3tr4A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQT_C_C5EC301_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3tr4 INORGANIC
PYROPHOSPHATASE
(Coxiella
burnetii) 		4 / 8 TYR A 140
TYR A  50
CYH A  52
ILE A 133
 None
 0.97A 4bqtC-3tr4A:
undetectable
4bqtD-3tr4A:
undetectable		 4bqtC-3tr4A:
25.00
4bqtD-3tr4A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_K_KANK301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3tr4 INORGANIC
PYROPHOSPHATASE
(Coxiella
burnetii) 		4 / 8 ASP A  41
ASP A 101
GLU A  30
GLU A  97
 None
MN  A 176 (-2.5A)
None
None
 0.89A 4gkhC-3tr4A:
undetectable
4gkhK-3tr4A:
undetectable		 4gkhC-3tr4A:
20.07
4gkhK-3tr4A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3tr4 INORGANIC
PYROPHOSPHATASE
(Coxiella
burnetii) 		4 / 8 ASP A  41
ASP A 101
GLU A  30
GLU A  97
 None
MN  A 176 (-2.5A)
None
None
 0.89A 4gkiE-3tr4A:
undetectable
4gkiG-3tr4A:
undetectable		 4gkiE-3tr4A:
20.07
4gkiG-3tr4A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_A_MTXA603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 3tr4 INORGANIC
PYROPHOSPHATASE
(Coxiella
burnetii) 		5 / 12 VAL A 107
ALA A  88
LEU A 122
ILE A 133
LEU A 129
 None
 0.99A 4ky8A-3tr4A:
undetectable		 4ky8A-3tr4A:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_B_MTXB603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 3tr4 INORGANIC
PYROPHOSPHATASE
(Coxiella
burnetii) 		5 / 12 VAL A 107
ALA A  88
LEU A 122
ILE A 133
LEU A 129
 None
 0.98A 4ky8B-3tr4A:
undetectable		 4ky8B-3tr4A:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_C_MTXC603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 3tr4 INORGANIC
PYROPHOSPHATASE
(Coxiella
burnetii) 		5 / 12 VAL A 107
ALA A  88
LEU A 122
ILE A 133
LEU A 129
 None
 1.00A 4ky8C-3tr4A:
undetectable		 4ky8C-3tr4A:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_D_MTXD603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 3tr4 INORGANIC
PYROPHOSPHATASE
(Coxiella
burnetii) 		5 / 12 VAL A 107
ALA A  88
LEU A 122
ILE A 133
LEU A 129
 None
 0.99A 4ky8D-3tr4A:
undetectable		 4ky8D-3tr4A:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_E_MTXE603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 3tr4 INORGANIC
PYROPHOSPHATASE
(Coxiella
burnetii) 		5 / 12 VAL A 107
ALA A  88
LEU A 122
ILE A 133
LEU A 129
 None
 0.98A 4ky8E-3tr4A:
undetectable		 4ky8E-3tr4A:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_A_MTXA604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3tr4 INORGANIC
PYROPHOSPHATASE
(Coxiella
burnetii) 		5 / 12 VAL A 107
ALA A  88
LEU A 122
ILE A 133
LEU A 129
 None
 0.98A 4q0dA-3tr4A:
undetectable		 4q0dA-3tr4A:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_B_MTXB604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3tr4 INORGANIC
PYROPHOSPHATASE
(Coxiella
burnetii) 		5 / 12 VAL A 107
ALA A  88
LEU A 122
ILE A 133
LEU A 129
 None
 0.98A 4q0dB-3tr4A:
undetectable		 4q0dB-3tr4A:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_E_MTXE604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3tr4 INORGANIC
PYROPHOSPHATASE
(Coxiella
burnetii) 		5 / 12 VAL A 107
ALA A  88
LEU A 122
ILE A 133
LEU A 129
 None
 0.98A 4q0dE-3tr4A:
undetectable		 4q0dE-3tr4A:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ5_B_ACTB404_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 3tr4 INORGANIC
PYROPHOSPHATASE
(Coxiella
burnetii) 		3 / 3 TYR A 140
ARG A  42
LYS A 141
 None
 1.36A 4wq5B-3tr4A:
undetectable		 4wq5B-3tr4A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AIN_A_QMRA1207_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3tr4 INORGANIC
PYROPHOSPHATASE
(Coxiella
burnetii) 		5 / 10 TYR A 140
TYR A  50
CYH A  52
VAL A 104
ILE A 133
 None
 1.31A 5ainA-3tr4A:
undetectable
5ainB-3tr4A:
0.0		 5ainA-3tr4A:
24.79
5ainB-3tr4A:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AIN_D_QMRD1207_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3tr4 INORGANIC
PYROPHOSPHATASE
(Coxiella
burnetii) 		5 / 10 TYR A 140
TYR A  50
CYH A  52
VAL A 104
ILE A 133
 None
 1.26A 5ainD-3tr4A:
undetectable
5ainE-3tr4A:
undetectable		 5ainD-3tr4A:
24.79
5ainE-3tr4A:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA603_1
(CHITINASE)		 3tr4 INORGANIC
PYROPHOSPHATASE
(Coxiella
burnetii) 		4 / 8 GLY A  55
GLU A  19
ASP A  41
ARG A  42
 None
 1.04A 5gqbA-3tr4A:
undetectable		 5gqbA-3tr4A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 3tr4 INORGANIC
PYROPHOSPHATASE
(Coxiella
burnetii) 		4 / 6 PHE A 164
LYS A 157
VAL A  86
ASP A  12
 None
 1.23A 5hesA-3tr4A:
undetectable		 5hesA-3tr4A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_D_SAMD301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3tr4 INORGANIC
PYROPHOSPHATASE
(Coxiella
burnetii) 		5 / 12 ASP A  32
PRO A  67
GLY A  55
GLU A  19
TYR A  54
 None
 1.07A 5hfjD-3tr4A:
undetectable		 5hfjD-3tr4A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_F_SAMF301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3tr4 INORGANIC
PYROPHOSPHATASE
(Coxiella
burnetii) 		5 / 12 ASP A  32
PRO A  67
GLY A  55
GLU A  19
TYR A  54
 None
 1.13A 5hfjF-3tr4A:
undetectable		 5hfjF-3tr4A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 3tr4 INORGANIC
PYROPHOSPHATASE
(Coxiella
burnetii) 		3 / 3 THR A  60
SER A 167
ASP A 101
 None
None
MN  A 176 (-2.5A)
 0.69A 5kvaA-3tr4A:
undetectable		 5kvaA-3tr4A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 3tr4 INORGANIC
PYROPHOSPHATASE
(Coxiella
burnetii) 		3 / 3 THR A  60
SER A 167
ASP A 101
 None
None
MN  A 176 (-2.5A)
 0.70A 5kvaB-3tr4A:
undetectable		 5kvaB-3tr4A:
21.63