SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tr5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_C_BEZC1162_0
(PEROXIREDOXIN 5)		 3tr5 PEPTIDE CHAIN
RELEASE FACTOR 3
(Coxiella
burnetii) 		5 / 9 PRO A 274
THR A   7
PRO A 357
GLY A 358
GLY A 277
 None
 1.26A 1h4oC-3tr5A:
undetectable
1h4oD-3tr5A:
undetectable		 1h4oC-3tr5A:
16.25
1h4oD-3tr5A:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_E_BEZE1162_0
(PEROXIREDOXIN 5)		 3tr5 PEPTIDE CHAIN
RELEASE FACTOR 3
(Coxiella
burnetii) 		5 / 9 PRO A 274
THR A   7
PRO A 357
GLY A 358
GLY A 277
 None
 1.26A 1h4oE-3tr5A:
undetectable
1h4oF-3tr5A:
undetectable		 1h4oE-3tr5A:
16.25
1h4oF-3tr5A:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1430_0
(FPRA)		 3tr5 PEPTIDE CHAIN
RELEASE FACTOR 3
(Coxiella
burnetii) 		3 / 3 ASP A  85
ASP A  91
LYS A 298
 None
 1.16A 1lquB-3tr5A:
undetectable		 1lquB-3tr5A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3tr5 PEPTIDE CHAIN
RELEASE FACTOR 3
(Coxiella
burnetii) 		4 / 6 LEU A 182
VAL A 116
ILE A 138
ARG A 160
 None
 1.10A 1opjB-3tr5A:
undetectable		 1opjB-3tr5A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_A_ADNA433_2
(ADENOSYLHOMOCYSTEINA
SE)		 3tr5 PEPTIDE CHAIN
RELEASE FACTOR 3
(Coxiella
burnetii) 		3 / 3 THR A 101
GLU A 279
HIS A 131
 None
 0.72A 1xwfA-3tr5A:
undetectable		 1xwfA-3tr5A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_B_ADNB433_2
(ADENOSYLHOMOCYSTEINA
SE)		 3tr5 PEPTIDE CHAIN
RELEASE FACTOR 3
(Coxiella
burnetii) 		3 / 3 THR A 101
GLU A 279
HIS A 131
 None
 0.73A 1xwfB-3tr5A:
undetectable		 1xwfB-3tr5A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_C_ADNC433_2
(ADENOSYLHOMOCYSTEINA
SE)		 3tr5 PEPTIDE CHAIN
RELEASE FACTOR 3
(Coxiella
burnetii) 		3 / 3 THR A 101
GLU A 279
HIS A 131
 None
 0.69A 1xwfC-3tr5A:
undetectable		 1xwfC-3tr5A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_D_ADND433_2
(ADENOSYLHOMOCYSTEINA
SE)		 3tr5 PEPTIDE CHAIN
RELEASE FACTOR 3
(Coxiella
burnetii) 		3 / 3 THR A 101
GLU A 279
HIS A 131
 None
 0.73A 1xwfD-3tr5A:
undetectable		 1xwfD-3tr5A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_B_SNLB503_2
(MINERALOCORTICOID
RECEPTOR)		 3tr5 PEPTIDE CHAIN
RELEASE FACTOR 3
(Coxiella
burnetii) 		4 / 5 LEU A 409
LEU A 408
LEU A 415
LEU A 423
 None
 0.96A 2ab2B-3tr5A:
undetectable		 2ab2B-3tr5A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2001_1
(SERUM ALBUMIN)		 3tr5 PEPTIDE CHAIN
RELEASE FACTOR 3
(Coxiella
burnetii) 		5 / 11 VAL A 261
GLY A 260
ALA A 255
LEU A  26
SER A  17
 None
None
GDP  A 527 (-4.2A)
None
GDP  A 527 ( 4.4A)
 1.17A 2bxgA-3tr5A:
undetectable		 2bxgA-3tr5A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 3tr5 PEPTIDE CHAIN
RELEASE FACTOR 3
(Coxiella
burnetii) 		4 / 5 SER A 391
GLY A 435
ASP A 428
ASP A 492
 None
 1.05A 2oxtB-3tr5A:
undetectable		 2oxtB-3tr5A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDB_A_NPSA1591_1
(SERUM ALBUMIN)		 3tr5 PEPTIDE CHAIN
RELEASE FACTOR 3
(Coxiella
burnetii) 		4 / 8 LEU A  30
PHE A  33
TYR A  76
GLY A 262
 None
 0.79A 2vdbA-3tr5A:
undetectable		 2vdbA-3tr5A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VL2_A_BEZA1162_0
(PEROXIREDOXIN-5)		 3tr5 PEPTIDE CHAIN
RELEASE FACTOR 3
(Coxiella
burnetii) 		5 / 10 PRO A 274
THR A   7
PRO A 357
GLY A 358
GLY A 277
 None
 1.30A 2vl2A-3tr5A:
undetectable
2vl2C-3tr5A:
undetectable		 2vl2A-3tr5A:
17.15
2vl2C-3tr5A:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DXY_A_SAMA1_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 3tr5 PEPTIDE CHAIN
RELEASE FACTOR 3
(Coxiella
burnetii) 		5 / 11 GLY A 253
GLY A 260
ILE A 138
ASP A 111
ALA A 112
 None
 0.86A 3dxyA-3tr5A:
undetectable		 3dxyA-3tr5A:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3tr5 PEPTIDE CHAIN
RELEASE FACTOR 3
(Coxiella
burnetii) 		4 / 5 PRO A 118
THR A  93
VAL A 437
GLY A 438
 None
 1.13A 3elzA-3tr5A:
undetectable		 3elzA-3tr5A:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB1_A_IMNA701_1
(LACTOTRANSFERRIN)		 3tr5 PEPTIDE CHAIN
RELEASE FACTOR 3
(Coxiella
burnetii) 		4 / 4 PRO A 133
THR A 132
GLY A 385
THR A 384
 None
 1.14A 3ib1A-3tr5A:
undetectable		 3ib1A-3tr5A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_1
(NEURAMINIDASE)		 3tr5 PEPTIDE CHAIN
RELEASE FACTOR 3
(Coxiella
burnetii) 		3 / 3 ARG A 468
GLU A 125
TYR A  97
 None
 0.87A 3k37B-3tr5A:
undetectable		 3k37B-3tr5A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_B_GLYB511_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3tr5 PEPTIDE CHAIN
RELEASE FACTOR 3
(Coxiella
burnetii) 		4 / 5 GLU A 418
LEU A 415
GLN A 414
LYS A 410
 None
None
CA  A 526 (-3.1A)
None
 1.35A 3pgyB-3tr5A:
1.5		 3pgyB-3tr5A:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3tr5 PEPTIDE CHAIN
RELEASE FACTOR 3
(Coxiella
burnetii) 		4 / 8 VAL A 444
VAL A 445
CYH A 457
LEU A 449
 None
 0.64A 3wzeA-3tr5A:
undetectable		 3wzeA-3tr5A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1478_0
(MJ0495-LIKE PROTEIN)		 3tr5 PEPTIDE CHAIN
RELEASE FACTOR 3
(Coxiella
burnetii) 		4 / 7 ASP A 142
GLY A 171
SER A 254
PHE A 259
 GDP  A 527 (-2.7A)
None
GDP  A 527 (-3.0A)
None
 0.86A 4ac9C-3tr5A:
15.6		 4ac9C-3tr5A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_A_SAMA301_0
(PUTATIVE RNA
METHYLASE)		 3tr5 PEPTIDE CHAIN
RELEASE FACTOR 3
(Coxiella
burnetii) 		5 / 12 THR A  86
GLY A  88
HIS A  18
SER A  70
THR A  99
 None
 1.30A 4pooA-3tr5A:
undetectable		 4pooA-3tr5A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3tr5 PEPTIDE CHAIN
RELEASE FACTOR 3
(Coxiella
burnetii) 		5 / 12 ALA A 355
ILE A 360
PHE A 292
GLY A 294
PHE A 295
 None
 0.92A 4rzvA-3tr5A:
undetectable		 4rzvA-3tr5A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_A_BEZA1001_0
(BENZOATE-COENZYME A
LIGASE)		 3tr5 PEPTIDE CHAIN
RELEASE FACTOR 3
(Coxiella
burnetii) 		4 / 8 ALA A 317
VAL A 285
PHE A 383
GLY A 294
 None
 0.58A 4zjzA-3tr5A:
undetectable		 4zjzA-3tr5A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3tr5 PEPTIDE CHAIN
RELEASE FACTOR 3
(Coxiella
burnetii) 		4 / 5 GLU A 521
THR A 522
GLU A  94
LEU A 123
 None
 0.86A 5hm8A-3tr5A:
2.1		 5hm8A-3tr5A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_B_ADNB501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3tr5 PEPTIDE CHAIN
RELEASE FACTOR 3
(Coxiella
burnetii) 		4 / 5 GLU A 521
THR A 522
GLU A  94
LEU A 123
 None
 0.86A 5hm8B-3tr5A:
2.3		 5hm8B-3tr5A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_C_ADNC501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3tr5 PEPTIDE CHAIN
RELEASE FACTOR 3
(Coxiella
burnetii) 		4 / 5 GLU A 521
THR A 522
GLU A  94
LEU A 123
 None
 0.86A 5hm8C-3tr5A:
2.2		 5hm8C-3tr5A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_D_ADND501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3tr5 PEPTIDE CHAIN
RELEASE FACTOR 3
(Coxiella
burnetii) 		4 / 5 GLU A 521
THR A 522
GLU A  94
LEU A 123
 None
 0.86A 5hm8D-3tr5A:
2.4		 5hm8D-3tr5A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_E_ADNE501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3tr5 PEPTIDE CHAIN
RELEASE FACTOR 3
(Coxiella
burnetii) 		4 / 5 GLU A 521
THR A 522
GLU A  94
LEU A 123
 None
 0.86A 5hm8E-3tr5A:
undetectable		 5hm8E-3tr5A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_F_ADNF501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3tr5 PEPTIDE CHAIN
RELEASE FACTOR 3
(Coxiella
burnetii) 		4 / 5 GLU A 521
THR A 522
GLU A  94
LEU A 123
 None
 0.86A 5hm8F-3tr5A:
undetectable		 5hm8F-3tr5A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_G_ADNG501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3tr5 PEPTIDE CHAIN
RELEASE FACTOR 3
(Coxiella
burnetii) 		4 / 5 GLU A 521
THR A 522
GLU A  94
LEU A 123
 None
 0.95A 5hm8G-3tr5A:
undetectable		 5hm8G-3tr5A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_H_ADNH501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3tr5 PEPTIDE CHAIN
RELEASE FACTOR 3
(Coxiella
burnetii) 		4 / 5 GLU A 521
THR A 522
GLU A  94
LEU A 123
 None
 0.86A 5hm8H-3tr5A:
undetectable		 5hm8H-3tr5A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3tr5 PEPTIDE CHAIN
RELEASE FACTOR 3
(Coxiella
burnetii) 		4 / 5 TYR A 242
MET A 135
THR A 136
LEU A 107
 None
 1.45A 5x1bJ-3tr5A:
undetectable		 5x1bJ-3tr5A:
6.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_B_TRPB403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 3tr5 PEPTIDE CHAIN
RELEASE FACTOR 3
(Coxiella
burnetii) 		4 / 7 ARG A 130
GLU A 524
ARG A 278
THR A 280
 None
 1.37A 6a4iB-3tr5A:
undetectable		 6a4iB-3tr5A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 3tr5 PEPTIDE CHAIN
RELEASE FACTOR 3
(Coxiella
burnetii) 		5 / 12 SER A  70
THR A  68
LEU A  59
GLY A  64
PHE A 313
 None
 1.20A 6a94B-3tr5A:
undetectable		 6a94B-3tr5A:
22.05