SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tr6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_1
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 3tr6 O-METHYLTRANSFERASE
(Coxiella
burnetii) 		4 / 5 ASP A  93
VAL A  94
SER A 120
ASP A  67
 SAH  A 224 (-3.0A)
SAH  A 224 (-4.7A)
None
SAH  A 224 ( 4.6A)
 1.31A 1n2xB-3tr6A:
15.4		 1n2xB-3tr6A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_1
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 3tr6 O-METHYLTRANSFERASE
(Coxiella
burnetii) 		4 / 5 ASP A  93
VAL A  94
SER A 120
ASP A 144
 SAH  A 224 (-3.0A)
SAH  A 224 (-4.7A)
None
NI  A 223 ( 2.5A)
 1.23A 1n2xB-3tr6A:
15.4		 1n2xB-3tr6A:
22.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AVD_A_SAMA501_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 3tr6 O-METHYLTRANSFERASE
(Coxiella
burnetii) 		9 / 12 GLY A  69
PHE A  71
TYR A  74
SER A  75
VAL A  94
ALA A 122
ALA A 145
ASP A 146
TYR A 153
 SAH  A 224 (-3.9A)
SAH  A 224 (-4.8A)
None
SAH  A 224 (-2.8A)
SAH  A 224 (-4.7A)
SAH  A 224 (-3.8A)
SAH  A 224 (-3.5A)
SAH  A 224 (-3.5A)
None
 0.42A 2avdA-3tr6A:
32.7		 2avdA-3tr6A:
46.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AVD_B_SAMB601_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 3tr6 O-METHYLTRANSFERASE
(Coxiella
burnetii) 		8 / 12 GLY A  69
PHE A  71
TYR A  74
VAL A  94
ALA A 122
ASP A 144
ALA A 145
TYR A 153
 SAH  A 224 (-3.9A)
SAH  A 224 (-4.8A)
None
SAH  A 224 (-4.7A)
SAH  A 224 (-3.8A)
NI  A 223 ( 2.5A)
SAH  A 224 (-3.5A)
None
 0.45A 2avdB-3tr6A:
32.9		 2avdB-3tr6A:
46.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_A_ADNA2001_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 3tr6 O-METHYLTRANSFERASE
(Coxiella
burnetii) 		4 / 7 ARG A  22
GLU A  23
ALA A  54
ALA A  78
 None
 0.87A 2ejfA-3tr6A:
undetectable		 2ejfA-3tr6A:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_A_SNLA1001_1
(MINERALOCORTICOID
RECEPTOR)		 3tr6 O-METHYLTRANSFERASE
(Coxiella
burnetii) 		5 / 12 LEU A 101
LEU A 111
LEU A  27
THR A  34
PHE A  71
 None
None
None
None
SAH  A 224 (-4.8A)
 1.45A 2oaxA-3tr6A:
undetectable		 2oaxA-3tr6A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 3tr6 O-METHYLTRANSFERASE
(Coxiella
burnetii) 		4 / 6 THR A  70
ASP A 144
ASN A 171
ASP A 213
 None
NI  A 223 ( 2.5A)
NI  A 223 (-2.8A)
None
 1.31A 2okcA-3tr6A:
12.9		 2okcA-3tr6A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LBD_A_9CRA424_1
(RETINOIC ACID
RECEPTOR GAMMA)		 3tr6 O-METHYLTRANSFERASE
(Coxiella
burnetii) 		5 / 12 LEU A  27
LEU A  30
ARG A  36
SER A  37
ALA A  50
 None
 1.23A 3lbdA-3tr6A:
undetectable		 3lbdA-3tr6A:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_1
(2'-O-METHYL
TRANSFERASE)		 3tr6 O-METHYLTRANSFERASE
(Coxiella
burnetii) 		3 / 3 TYR A 154
ASP A 205
ASP A 201
 None
 0.71A 3r24A-3tr6A:
8.9		 3r24A-3tr6A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S68_A_TCWA227_1
(CATECHOL
O-METHYLTRANSFERASE)		 3tr6 O-METHYLTRANSFERASE
(Coxiella
burnetii) 		5 / 10 MET A  43
ASP A 144
LYS A 147
ASP A 170
ASN A 171
 SAH  A 224 (-3.7A)
NI  A 223 ( 2.5A)
NI  A 223 ( 4.1A)
NI  A 223 (-3.3A)
NI  A 223 (-2.8A)
 0.48A 3s68A-3tr6A:
22.0		 3s68A-3tr6A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A84_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 3tr6 O-METHYLTRANSFERASE
(Coxiella
burnetii) 		5 / 12 PRO A  24
LEU A  83
VAL A  57
ALA A  50
SER A  75
 None
None
None
None
SAH  A 224 (-2.8A)
 1.22A 4a84A-3tr6A:
undetectable		 4a84A-3tr6A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_2
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 3tr6 O-METHYLTRANSFERASE
(Coxiella
burnetii) 		3 / 3 LYS A 147
THR A 150
ILE A 167
 NI  A 223 ( 4.1A)
None
None
 0.88A 4e0fB-3tr6A:
undetectable		 4e0fB-3tr6A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1R_A_LZUA801_1
(MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1)		 3tr6 O-METHYLTRANSFERASE
(Coxiella
burnetii) 		5 / 12 LEU A  89
LYS A  63
VAL A  65
ALA A  76
LEU A  81
 None
 1.06A 4i1rA-3tr6A:
undetectable		 4i1rA-3tr6A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_A_MXMA606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3tr6 O-METHYLTRANSFERASE
(Coxiella
burnetii) 		5 / 12 LEU A  30
LEU A 119
ALA A 100
SER A  98
LEU A 101
 None
None
None
SAH  A 224 ( 4.5A)
None
 1.47A 4m11A-3tr6A:
undetectable		 4m11A-3tr6A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_A_SAMA301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 3tr6 O-METHYLTRANSFERASE
(Coxiella
burnetii) 		5 / 12 GLN A  44
GLY A  69
ALA A 122
ALA A 145
TYR A 153
 None
SAH  A 224 (-3.9A)
SAH  A 224 (-3.8A)
SAH  A 224 (-3.5A)
None
 0.57A 4pclA-3tr6A:
28.7		 4pclA-3tr6A:
28.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_A_SAMA301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 3tr6 O-METHYLTRANSFERASE
(Coxiella
burnetii) 		5 / 12 GLN A  44
GLY A  69
ASP A  95
ALA A 145
TYR A 153
 None
SAH  A 224 (-3.9A)
None
SAH  A 224 (-3.5A)
None
 0.81A 4pclA-3tr6A:
28.7		 4pclA-3tr6A:
28.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_B_SAMB301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 3tr6 O-METHYLTRANSFERASE
(Coxiella
burnetii) 		5 / 12 GLN A  44
GLY A  69
ALA A 122
ALA A 145
TYR A 153
 None
SAH  A 224 (-3.9A)
SAH  A 224 (-3.8A)
SAH  A 224 (-3.5A)
None
 0.61A 4pclB-3tr6A:
29.0		 4pclB-3tr6A:
28.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PYL_A_TCWA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 3tr6 O-METHYLTRANSFERASE
(Coxiella
burnetii) 		5 / 10 MET A  43
ASP A 144
LYS A 147
ASP A 170
ASN A 171
 SAH  A 224 (-3.7A)
NI  A 223 ( 2.5A)
NI  A 223 ( 4.1A)
NI  A 223 (-3.3A)
NI  A 223 (-2.8A)
 0.41A 4pylA-3tr6A:
22.8		 4pylA-3tr6A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 3tr6 O-METHYLTRANSFERASE
(Coxiella
burnetii) 		5 / 12 THR A  45
GLY A  69
GLY A  73
ALA A 122
ALA A 145
 SAH  A 224 (-3.6A)
SAH  A 224 (-3.9A)
None
SAH  A 224 (-3.8A)
SAH  A 224 (-3.5A)
 0.94A 4uciA-3tr6A:
7.8		 4uciA-3tr6A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 3tr6 O-METHYLTRANSFERASE
(Coxiella
burnetii) 		5 / 12 THR A  45
GLY A  69
GLY A  73
ALA A 122
ALA A 145
 SAH  A 224 (-3.6A)
SAH  A 224 (-3.9A)
None
SAH  A 224 (-3.8A)
SAH  A 224 (-3.5A)
 0.93A 4uciB-3tr6A:
7.9		 4uciB-3tr6A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 3tr6 O-METHYLTRANSFERASE
(Coxiella
burnetii) 		5 / 12 THR A  45
GLY A  69
GLY A  73
ALA A 122
ALA A 145
 SAH  A 224 (-3.6A)
SAH  A 224 (-3.9A)
None
SAH  A 224 (-3.8A)
SAH  A 224 (-3.5A)
 0.92A 4uckA-3tr6A:
7.8		 4uckA-3tr6A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3tr6 O-METHYLTRANSFERASE
(Coxiella
burnetii) 		4 / 6 LEU A 129
ILE A 130
LEU A 160
TYR A 138
 None
 0.73A 4w5nA-3tr6A:
2.2		 4w5nA-3tr6A:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 3tr6 O-METHYLTRANSFERASE
(Coxiella
burnetii) 		4 / 5 GLY A  69
TYR A  74
SER A  75
ASP A 144
 SAH  A 224 (-3.9A)
None
SAH  A 224 (-2.8A)
NI  A 223 ( 2.5A)
 0.46A 4xueA-3tr6A:
22.3		 4xueA-3tr6A:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_A_SAMA1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 3tr6 O-METHYLTRANSFERASE
(Coxiella
burnetii) 		5 / 12 GLY A  69
TYR A  74
ALA A 122
ALA A 145
TYR A 153
 SAH  A 224 (-3.9A)
None
SAH  A 224 (-3.8A)
SAH  A 224 (-3.5A)
None
 0.35A 4ymgA-3tr6A:
26.4		 4ymgA-3tr6A:
27.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 3tr6 O-METHYLTRANSFERASE
(Coxiella
burnetii) 		7 / 12 GLY A  69
TYR A  74
SER A  75
ALA A 122
ASP A 144
ALA A 145
TYR A 153
 SAH  A 224 (-3.9A)
None
SAH  A 224 (-2.8A)
SAH  A 224 (-3.8A)
NI  A 223 ( 2.5A)
SAH  A 224 (-3.5A)
None
 0.42A 4ymgB-3tr6A:
25.7		 4ymgB-3tr6A:
27.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KVA_A_SAMA301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 3tr6 O-METHYLTRANSFERASE
(Coxiella
burnetii) 		8 / 12 MET A  43
GLY A  69
TYR A  74
ALA A 122
ASP A 144
ALA A 145
ASP A 146
TYR A 153
 SAH  A 224 (-3.7A)
SAH  A 224 (-3.9A)
None
SAH  A 224 (-3.8A)
NI  A 223 ( 2.5A)
SAH  A 224 (-3.5A)
SAH  A 224 (-3.5A)
None
 0.63A 5kvaA-3tr6A:
31.3		 5kvaA-3tr6A:
33.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KVA_A_SAMA301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 3tr6 O-METHYLTRANSFERASE
(Coxiella
burnetii) 		3 / 3 THR A  45
SER A  75
ASP A  93
 SAH  A 224 (-3.6A)
SAH  A 224 (-2.8A)
SAH  A 224 (-3.0A)
 0.19A 5kvaA-3tr6A:
31.3		 5kvaA-3tr6A:
33.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KVA_B_SAMB301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 3tr6 O-METHYLTRANSFERASE
(Coxiella
burnetii) 		8 / 12 MET A  43
GLY A  69
TYR A  74
ALA A 122
ASP A 144
ALA A 145
ASP A 146
TYR A 153
 SAH  A 224 (-3.7A)
SAH  A 224 (-3.9A)
None
SAH  A 224 (-3.8A)
NI  A 223 ( 2.5A)
SAH  A 224 (-3.5A)
SAH  A 224 (-3.5A)
None
 0.67A 5kvaB-3tr6A:
31.2		 5kvaB-3tr6A:
33.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KVA_B_SAMB301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 3tr6 O-METHYLTRANSFERASE
(Coxiella
burnetii) 		3 / 3 THR A  45
SER A  75
ASP A  93
 SAH  A 224 (-3.6A)
SAH  A 224 (-2.8A)
SAH  A 224 (-3.0A)
 0.18A 5kvaB-3tr6A:
31.2		 5kvaB-3tr6A:
33.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LOG_A_LDPA1004_1
(PUTATIVE
O-METHYLTRANSFERASE)		 3tr6 O-METHYLTRANSFERASE
(Coxiella
burnetii) 		5 / 6 MET A  43
ASP A 144
LYS A 147
ASP A 170
ASN A 171
 SAH  A 224 (-3.7A)
NI  A 223 ( 2.5A)
NI  A 223 ( 4.1A)
NI  A 223 (-3.3A)
NI  A 223 (-2.8A)
 0.37A 5logA-3tr6A:
33.1		 5logA-3tr6A:
45.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5D_A_SAMA306_0
(METHYLTRANSFERASE)		 3tr6 O-METHYLTRANSFERASE
(Coxiella
burnetii) 		5 / 12 GLY A  69
TYR A  74
ALA A 122
ALA A 145
TYR A 153
 SAH  A 224 (-3.9A)
None
SAH  A 224 (-3.8A)
SAH  A 224 (-3.5A)
None
 0.36A 5n5dA-3tr6A:
28.5		 5n5dA-3tr6A:
30.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5D_B_SAMB303_1
(METHYLTRANSFERASE)		 3tr6 O-METHYLTRANSFERASE
(Coxiella
burnetii) 		4 / 7 GLY A  69
PHE A  71
SER A  75
ASP A 144
 SAH  A 224 (-3.9A)
SAH  A 224 (-4.8A)
SAH  A 224 (-2.8A)
NI  A 223 ( 2.5A)
 0.30A 5n5dB-3tr6A:
28.8		 5n5dB-3tr6A:
30.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 3tr6 O-METHYLTRANSFERASE
(Coxiella
burnetii) 		5 / 12 ILE A 211
LEU A 217
ALA A  76
GLY A  73
TYR A  74
 None
 1.11A 5uxdB-3tr6A:
undetectable		 5uxdB-3tr6A:
21.64