SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tr9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ4_A_CAMA502_0
(CYTOCHROME P450-CAM)		 3tr9 DIHYDROPTEROATE
SYNTHASE
(Coxiella
burnetii) 		4 / 6 PHE A 202
LEU A 172
VAL A 175
VAL A 231
 None
 0.87A 1dz4A-3tr9A:
undetectable		 1dz4A-3tr9A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N6C_A_SAMA402_0
(SET
DOMAIN-CONTAINING
PROTEIN 7)		 3tr9 DIHYDROPTEROATE
SYNTHASE
(Coxiella
burnetii) 		5 / 11 ILE A  34
GLY A  69
GLU A  89
ASN A  39
HIS A  43
 None
 1.24A 1n6cA-3tr9A:
undetectable		 1n6cA-3tr9A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_A_C2FA801_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 3tr9 DIHYDROPTEROATE
SYNTHASE
(Coxiella
burnetii) 		5 / 12 ASN A  35
ASP A 111
ASN A 130
ASP A 199
SER A 236
 CL  A 315 (-3.6A)
PT1  A1001 ( 3.4A)
PT1  A1001 ( 2.9A)
PT1  A1001 (-3.3A)
None
 0.77A 1q8jA-3tr9A:
5.2		 1q8jA-3tr9A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_A_C2FA801_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 3tr9 DIHYDROPTEROATE
SYNTHASE
(Coxiella
burnetii) 		5 / 12 ASP A  67
ASN A 130
ASP A 199
GLY A 234
SER A 236
 None
PT1  A1001 ( 2.9A)
PT1  A1001 (-3.3A)
PT1  A1001 (-3.9A)
None
 1.24A 1q8jA-3tr9A:
5.2		 1q8jA-3tr9A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_A_C2FA801_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 3tr9 DIHYDROPTEROATE
SYNTHASE
(Coxiella
burnetii) 		5 / 12 ASP A 111
ASN A 130
ASP A 199
GLY A 234
SER A 236
 PT1  A1001 ( 3.4A)
PT1  A1001 ( 2.9A)
PT1  A1001 (-3.3A)
PT1  A1001 (-3.9A)
None
 0.72A 1q8jA-3tr9A:
5.2		 1q8jA-3tr9A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T87_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 3tr9 DIHYDROPTEROATE
SYNTHASE
(Coxiella
burnetii) 		4 / 7 PHE A 202
LEU A 172
VAL A 175
VAL A 231
 None
 0.87A 1t87B-3tr9A:
undetectable		 1t87B-3tr9A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T88_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 3tr9 DIHYDROPTEROATE
SYNTHASE
(Coxiella
burnetii) 		4 / 5 PHE A 202
LEU A 172
VAL A 175
VAL A 231
 None
 0.86A 1t88B-3tr9A:
undetectable		 1t88B-3tr9A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3tr9 DIHYDROPTEROATE
SYNTHASE
(Coxiella
burnetii) 		3 / 3 MET A 240
ASN A 206
GLN A 132
 PT1  A1001 ( 4.2A)
None
PT1  A1001 ( 3.4A)
 1.01A 1xoqB-3tr9A:
undetectable		 1xoqB-3tr9A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YRD_A_CAMA420_0
(CYTOCHROME P450-CAM)		 3tr9 DIHYDROPTEROATE
SYNTHASE
(Coxiella
burnetii) 		4 / 7 PHE A 202
LEU A 172
VAL A 175
VAL A 231
 None
 0.87A 1yrdA-3tr9A:
undetectable		 1yrdA-3tr9A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FEU_A_CAMA1420_0
(CYTOCHROME P450-CAM)		 3tr9 DIHYDROPTEROATE
SYNTHASE
(Coxiella
burnetii) 		4 / 6 PHE A 202
LEU A 172
VAL A 175
VAL A 231
 None
 0.91A 2feuA-3tr9A:
undetectable		 2feuA-3tr9A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FEU_B_CAMB1421_0
(CYTOCHROME P450-CAM)		 3tr9 DIHYDROPTEROATE
SYNTHASE
(Coxiella
burnetii) 		4 / 7 PHE A 202
LEU A 172
VAL A 175
VAL A 231
 None
 0.92A 2feuB-3tr9A:
undetectable		 2feuB-3tr9A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M56_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 3tr9 DIHYDROPTEROATE
SYNTHASE
(Coxiella
burnetii) 		4 / 5 PHE A 202
LEU A 172
VAL A 175
VAL A 231
 None
 0.84A 2m56A-3tr9A:
undetectable		 2m56A-3tr9A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBL_A_CAMA517_0
(CYTOCHROME P450-CAM)		 3tr9 DIHYDROPTEROATE
SYNTHASE
(Coxiella
burnetii) 		4 / 7 PHE A 202
LEU A 172
VAL A 175
VAL A 231
 None
 0.82A 2qblA-3tr9A:
undetectable		 2qblA-3tr9A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YCJ_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 3tr9 DIHYDROPTEROATE
SYNTHASE
(Coxiella
burnetii) 		5 / 12 ASP A  67
ASN A 130
ASP A 199
GLY A 234
SER A 236
 None
PT1  A1001 ( 2.9A)
PT1  A1001 (-3.3A)
PT1  A1001 (-3.9A)
None
 1.27A 2ycjA-3tr9A:
21.8		 2ycjA-3tr9A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YCJ_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 3tr9 DIHYDROPTEROATE
SYNTHASE
(Coxiella
burnetii) 		5 / 12 ASP A 111
ASN A 130
ASP A 199
GLY A 234
SER A 236
 PT1  A1001 ( 3.4A)
PT1  A1001 ( 2.9A)
PT1  A1001 (-3.3A)
PT1  A1001 (-3.9A)
None
 0.83A 2ycjA-3tr9A:
21.8		 2ycjA-3tr9A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWG_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 3tr9 DIHYDROPTEROATE
SYNTHASE
(Coxiella
burnetii) 		4 / 6 PHE A 202
LEU A 172
VAL A 175
VAL A 231
 None
 0.91A 3fwgA-3tr9A:
undetectable		 3fwgA-3tr9A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWI_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 3tr9 DIHYDROPTEROATE
SYNTHASE
(Coxiella
burnetii) 		4 / 7 PHE A 202
LEU A 172
VAL A 175
VAL A 231
 None
 0.88A 3fwiA-3tr9A:
undetectable		 3fwiA-3tr9A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L63_A_CAMA440_0
(CAMPHOR
5-MONOOXYGENASE)		 3tr9 DIHYDROPTEROATE
SYNTHASE
(Coxiella
burnetii) 		4 / 7 PHE A 202
LEU A 172
VAL A 175
VAL A 231
 None
 0.95A 3l63A-3tr9A:
undetectable		 3l63A-3tr9A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3tr9 DIHYDROPTEROATE
SYNTHASE
(Coxiella
burnetii) 		5 / 12 ILE A  97
LEU A  93
ASP A  67
THR A  54
VAL A  36
 None
 1.06A 3rukA-3tr9A:
undetectable		 3rukA-3tr9A:
20.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TZF_B_08DB280_1
(7,8-DIHYDROPTEROATE
SYNTHASE)		 3tr9 DIHYDROPTEROATE
SYNTHASE
(Coxiella
burnetii) 		4 / 8 PHE A  41
GLY A 203
LYS A 238
SER A 239
 PT1  A1001 ( 3.6A)
PT1  A1001 (-3.6A)
PT1  A1001 (-2.6A)
PT1  A1001 (-2.7A)
 0.66A 3tzfB-3tr9A:
37.7		 3tzfB-3tr9A:
40.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRL_E_CAME503_0
(CAMPHOR
5-MONOOXYGENASE)		 3tr9 DIHYDROPTEROATE
SYNTHASE
(Coxiella
burnetii) 		4 / 7 PHE A 202
LEU A 172
VAL A 175
VAL A 231
 None
 0.95A 3wrlE-3tr9A:
undetectable		 3wrlE-3tr9A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRM_F_CAMF503_0
(CAMPHOR
5-MONOOXYGENASE)		 3tr9 DIHYDROPTEROATE
SYNTHASE
(Coxiella
burnetii) 		4 / 7 PHE A 202
LEU A 172
VAL A 175
VAL A 231
 None
 0.92A 3wrmF-3tr9A:
undetectable		 3wrmF-3tr9A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 3tr9 DIHYDROPTEROATE
SYNTHASE
(Coxiella
burnetii) 		5 / 12 ASN A  35
ASP A 111
ASP A 199
GLY A 234
SER A 236
 CL  A 315 (-3.6A)
PT1  A1001 ( 3.4A)
PT1  A1001 (-3.3A)
PT1  A1001 (-3.9A)
None
 0.83A 4djeA-3tr9A:
21.7		 4djeA-3tr9A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_B_C2FB302_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 3tr9 DIHYDROPTEROATE
SYNTHASE
(Coxiella
burnetii) 		5 / 12 ASP A  67
ASN A 130
ASP A 199
GLY A 234
SER A 236
 None
PT1  A1001 ( 2.9A)
PT1  A1001 (-3.3A)
PT1  A1001 (-3.9A)
None
 1.15A 4djeB-3tr9A:
21.8		 4djeB-3tr9A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_B_C2FB302_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 3tr9 DIHYDROPTEROATE
SYNTHASE
(Coxiella
burnetii) 		6 / 12 ASP A  67
ASP A 111
ASN A 130
ASP A 199
GLY A 234
SER A 236
 None
PT1  A1001 ( 3.4A)
PT1  A1001 ( 2.9A)
PT1  A1001 (-3.3A)
PT1  A1001 (-3.9A)
None
 0.82A 4djeB-3tr9A:
21.8		 4djeB-3tr9A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_B_C2FB300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 3tr9 DIHYDROPTEROATE
SYNTHASE
(Coxiella
burnetii) 		5 / 12 ASP A  67
ASP A 111
ASN A 130
GLY A 234
SER A 236
 None
PT1  A1001 ( 3.4A)
PT1  A1001 ( 2.9A)
PT1  A1001 (-3.9A)
None
 0.80A 4djfB-3tr9A:
21.9		 4djfB-3tr9A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3tr9 DIHYDROPTEROATE
SYNTHASE
(Coxiella
burnetii) 		5 / 11 ILE A  34
GLY A  69
GLU A  89
ASN A  39
HIS A  43
 None
 1.22A 4e47A-3tr9A:
undetectable		 4e47A-3tr9A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_B_SAMB800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3tr9 DIHYDROPTEROATE
SYNTHASE
(Coxiella
burnetii) 		5 / 11 ILE A  34
GLY A  69
GLU A  89
ASN A  39
HIS A  43
 None
 1.22A 4e47B-3tr9A:
undetectable		 4e47B-3tr9A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_C_SAMC800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3tr9 DIHYDROPTEROATE
SYNTHASE
(Coxiella
burnetii) 		5 / 11 ILE A  34
GLY A  69
GLU A  89
ASN A  39
HIS A  43
 None
 1.23A 4e47C-3tr9A:
undetectable		 4e47C-3tr9A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G3R_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 3tr9 DIHYDROPTEROATE
SYNTHASE
(Coxiella
burnetii) 		4 / 6 PHE A 202
LEU A 172
VAL A 175
VAL A 231
 None
 0.91A 4g3rA-3tr9A:
undetectable		 4g3rA-3tr9A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G3R_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 3tr9 DIHYDROPTEROATE
SYNTHASE
(Coxiella
burnetii) 		4 / 6 PHE A 202
LEU A 172
VAL A 175
VAL A 231
 None
 0.91A 4g3rB-3tr9A:
undetectable		 4g3rB-3tr9A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J5J_B_478B401_2
(PROTEASE)		 3tr9 DIHYDROPTEROATE
SYNTHASE
(Coxiella
burnetii) 		5 / 10 ASP A  64
ALA A  29
ILE A 271
VAL A 264
VAL A 276
 None
 1.08A 4j5jB-3tr9A:
undetectable		 4j5jB-3tr9A:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3tr9 DIHYDROPTEROATE
SYNTHASE
(Coxiella
burnetii) 		5 / 11 ILE A  34
GLY A  69
GLU A  89
ASN A  39
HIS A  43
 None
 1.26A 4jdsA-3tr9A:
undetectable		 4jdsA-3tr9A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_B_SAMB401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3tr9 DIHYDROPTEROATE
SYNTHASE
(Coxiella
burnetii) 		5 / 11 ILE A  34
GLY A  69
GLU A  89
ASN A  39
HIS A  43
 None
 1.24A 4jdsB-3tr9A:
undetectable		 4jdsB-3tr9A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_C_SAMC401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3tr9 DIHYDROPTEROATE
SYNTHASE
(Coxiella
burnetii) 		5 / 11 ILE A  34
GLY A  69
GLU A  89
ASN A  39
HIS A  43
 None
 1.24A 4jdsC-3tr9A:
undetectable		 4jdsC-3tr9A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLG_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3tr9 DIHYDROPTEROATE
SYNTHASE
(Coxiella
burnetii) 		5 / 12 ILE A  34
GLY A  69
GLU A  89
ASN A  39
HIS A  43
 None
 1.23A 4jlgA-3tr9A:
undetectable		 4jlgA-3tr9A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L49_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 3tr9 DIHYDROPTEROATE
SYNTHASE
(Coxiella
burnetii) 		4 / 5 PHE A 202
LEU A 172
VAL A 175
VAL A 231
 None
 0.91A 4l49A-3tr9A:
undetectable		 4l49A-3tr9A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 3tr9 DIHYDROPTEROATE
SYNTHASE
(Coxiella
burnetii) 		3 / 3 ASP A  67
VAL A  59
ASN A  35
 None
None
CL  A 315 (-3.6A)
 0.62A 4lmnA-3tr9A:
undetectable		 4lmnA-3tr9A:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_A_ADNA301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 3tr9 DIHYDROPTEROATE
SYNTHASE
(Coxiella
burnetii) 		5 / 9 GLY A  32
GLU A  61
ILE A 257
VAL A 276
THR A 279
 None
 1.45A 4x3mA-3tr9A:
3.6		 4x3mA-3tr9A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_A_29SA601_1
(ESTROGEN RECEPTOR)		 3tr9 DIHYDROPTEROATE
SYNTHASE
(Coxiella
burnetii) 		5 / 12 THR A 143
ALA A 140
ASP A 139
LEU A 137
LEU A 153
 None
 1.33A 4xi3A-3tr9A:
undetectable		 4xi3A-3tr9A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_1
(ESTROGEN RECEPTOR)		 3tr9 DIHYDROPTEROATE
SYNTHASE
(Coxiella
burnetii) 		5 / 12 THR A 143
LEU A 141
ALA A 140
LEU A 137
LEU A 153
 None
 0.98A 4xi3C-3tr9A:
undetectable		 4xi3C-3tr9A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3tr9 DIHYDROPTEROATE
SYNTHASE
(Coxiella
burnetii) 		5 / 11 ILE A  34
GLY A  69
GLU A  89
ASN A  39
HIS A  43
 None
 1.21A 5ayfA-3tr9A:
undetectable		 5ayfA-3tr9A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 3tr9 DIHYDROPTEROATE
SYNTHASE
(Coxiella
burnetii) 		3 / 3 HIS A 155
SER A 233
ASN A 214
 None
 0.73A 5cprB-3tr9A:
undetectable		 5cprB-3tr9A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_A_SAMA801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 3tr9 DIHYDROPTEROATE
SYNTHASE
(Coxiella
burnetii) 		5 / 12 ILE A  97
GLY A 125
ALA A 121
LEU A  93
VAL A 117
 None
 1.26A 5hw4A-3tr9A:
undetectable		 5hw4A-3tr9A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_B_SAMB801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 3tr9 DIHYDROPTEROATE
SYNTHASE
(Coxiella
burnetii) 		5 / 11 ILE A  97
GLY A 125
ALA A 121
LEU A  93
VAL A 117
 None
 1.27A 5hw4B-3tr9A:
undetectable		 5hw4B-3tr9A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 3tr9 DIHYDROPTEROATE
SYNTHASE
(Coxiella
burnetii) 		5 / 10 ALA A 286
THR A 287
GLY A 267
ALA A 263
ASP A 260
 None
 1.37A 5l66K-3tr9A:
undetectable
5l66L-3tr9A:
undetectable		 5l66K-3tr9A:
20.92
5l66L-3tr9A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 3tr9 DIHYDROPTEROATE
SYNTHASE
(Coxiella
burnetii) 		5 / 10 ALA A 286
THR A 287
GLY A 267
ALA A 263
ASP A 260
 None
 1.37A 5l66Y-3tr9A:
undetectable
5l66Z-3tr9A:
undetectable		 5l66Y-3tr9A:
20.92
5l66Z-3tr9A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3tr9 DIHYDROPTEROATE
SYNTHASE
(Coxiella
burnetii) 		4 / 5 ASN A  35
ASP A 111
ASN A 130
ASP A 199
 CL  A 315 (-3.6A)
PT1  A1001 ( 3.4A)
PT1  A1001 ( 2.9A)
PT1  A1001 (-3.3A)
 0.76A 5vooA-3tr9A:
8.3		 5vooA-3tr9A:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3tr9 DIHYDROPTEROATE
SYNTHASE
(Coxiella
burnetii) 		4 / 5 ASN A  35
ASP A 111
ASN A 130
ASP A 199
 CL  A 315 (-3.6A)
PT1  A1001 ( 3.4A)
PT1  A1001 ( 2.9A)
PT1  A1001 (-3.3A)
 0.77A 5vooC-3tr9A:
19.4		 5vooC-3tr9A:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3tr9 DIHYDROPTEROATE
SYNTHASE
(Coxiella
burnetii) 		4 / 5 ASN A  35
ASP A 111
ASN A 130
ASP A 199
 CL  A 315 (-3.6A)
PT1  A1001 ( 3.4A)
PT1  A1001 ( 2.9A)
PT1  A1001 (-3.3A)
 0.87A 5vooE-3tr9A:
19.3		 5vooE-3tr9A:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3tr9 DIHYDROPTEROATE
SYNTHASE
(Coxiella
burnetii) 		3 / 3 ASP A 111
ASN A 130
ASP A 199
 PT1  A1001 ( 3.4A)
PT1  A1001 ( 2.9A)
PT1  A1001 (-3.3A)
 0.26A 5vopA-3tr9A:
19.4		 5vopA-3tr9A:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3tr9 DIHYDROPTEROATE
SYNTHASE
(Coxiella
burnetii) 		3 / 3 ASP A 111
ASN A 130
ASP A 199
 PT1  A1001 ( 3.4A)
PT1  A1001 ( 2.9A)
PT1  A1001 (-3.3A)
 0.21A 5vopB-3tr9A:
19.3		 5vopB-3tr9A:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 3tr9 DIHYDROPTEROATE
SYNTHASE
(Coxiella
burnetii) 		4 / 5 HIS A 274
ASP A 111
GLY A  69
ASN A  35
 CL  A 315 (-4.4A)
PT1  A1001 ( 3.4A)
None
CL  A 315 (-3.6A)
 1.14A 5x7pB-3tr9A:
3.3		 5x7pB-3tr9A:
12.70