SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3trc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3trc PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE
(Coxiella
burnetii) 		4 / 6 LEU A 165
ILE A  44
ILE A 129
LEU A 148
 None
 0.98A 2xkwB-3trcA:
undetectable		 2xkwB-3trcA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 3trc PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE
(Coxiella
burnetii) 		5 / 12 LEU A   7
ILE A  44
MET A  55
VAL A  27
ILE A 115
 None
 1.13A 3gwxB-3trcA:
undetectable		 3gwxB-3trcA:
25.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_B_CL6B506_1
(CHOLESTEROL
24-HYDROXYLASE)		 3trc PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE
(Coxiella
burnetii) 		5 / 12 LEU A  35
THR A 147
ALA A 143
GLU A 141
ALA A   0
 None
 0.96A 3mdvB-3trcA:
undetectable		 3mdvB-3trcA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 3trc PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE
(Coxiella
burnetii) 		4 / 8 LEU A  26
LEU A  31
HIS A 151
LEU A 152
 None
 1.22A 5dxeA-3trcA:
undetectable		 5dxeA-3trcA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3trc PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE
(Coxiella
burnetii) 		4 / 5 SER A 134
ALA A  90
HIS A 110
LEU A  94
 None
 1.24A 5dzkb-3trcA:
undetectable
5dzkp-3trcA:
undetectable		 5dzkb-3trcA:
23.89
5dzkp-3trcA:
1.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3trc PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE
(Coxiella
burnetii) 		4 / 6 SER A 134
ALA A  90
HIS A 110
LEU A  94
 None
 1.27A 5dzkB-3trcA:
undetectable
5dzkP-3trcA:
undetectable		 5dzkB-3trcA:
23.89
5dzkP-3trcA:
1.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Q_BEZQ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3trc PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE
(Coxiella
burnetii) 		4 / 5 SER A 134
ALA A  90
HIS A 110
LEU A  94
 None
 1.24A 5dzkc-3trcA:
undetectable
5dzkq-3trcA:
undetectable		 5dzkc-3trcA:
23.89
5dzkq-3trcA:
1.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3trc PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE
(Coxiella
burnetii) 		4 / 7 SER A 134
ALA A  90
HIS A 110
LEU A  94
 None
 1.11A 5dzkD-3trcA:
undetectable
5dzkR-3trcA:
undetectable		 5dzkD-3trcA:
23.89
5dzkR-3trcA:
1.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3trc PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE
(Coxiella
burnetii) 		4 / 5 SER A 134
ALA A  90
HIS A 110
LEU A  94
 None
 1.09A 5dzkf-3trcA:
undetectable
5dzkt-3trcA:
undetectable		 5dzkf-3trcA:
23.89
5dzkt-3trcA:
1.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_U_BEZU801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3trc PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE
(Coxiella
burnetii) 		4 / 6 SER A 134
ALA A  90
HIS A 110
LEU A  94
 None
 1.21A 5dzkg-3trcA:
undetectable
5dzku-3trcA:
undetectable		 5dzkg-3trcA:
23.89
5dzku-3trcA:
1.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA503_1
(-)		 3trc PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE
(Coxiella
burnetii) 		5 / 9 LEU A  60
ILE A  77
LEU A  68
PRO A  93
ALA A  92
 None
PO4  A 169 (-3.6A)
None
None
None
 1.16A 5og9A-3trcA:
undetectable		 5og9A-3trcA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_A_ESTA601_1
(ESTROGEN RECEPTOR)		 3trc PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE
(Coxiella
burnetii) 		4 / 8 LEU A  26
LEU A  31
HIS A 151
LEU A 152
 None
 1.22A 6cbzA-3trcA:
undetectable		 6cbzA-3trcA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_1
(ADENOSYLHOMOCYSTEINA
SE)		 3trc PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE
(Coxiella
burnetii) 		3 / 3 LEU A 104
GLN A  64
LYS A  99
 None
 0.89A 6exiB-3trcA:
undetectable		 6exiB-3trcA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_0
(ADENOSYLHOMOCYSTEINA
SE)		 3trc PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE
(Coxiella
burnetii) 		3 / 3 LEU A 104
GLN A  64
LYS A  99
 None
 0.91A 6exiA-3trcA:
undetectable		 6exiA-3trcA:
20.48