SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3trd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HO5_A_ADNA1604_1
(5'-NUCLEOTIDASE)		 3trd ALPHA/BETA HYDROLASE
(Coxiella
burnetii) 		5 / 11 ILE A  33
SER A 116
GLY A 112
PHE A  68
GLY A 108
 None
 1.48A 1ho5A-3trdA:
undetectable		 1ho5A-3trdA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1300_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 3trd ALPHA/BETA HYDROLASE
(Coxiella
burnetii) 		5 / 11 PHE A 111
PHE A 136
VAL A 160
VAL A 161
HIS A 187
 None
ACT  A 206 (-4.8A)
ACT  A 206 (-4.9A)
None
None
 0.95A 1ukbA-3trdA:
19.2		 1ukbA-3trdA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGX_B_SALB104_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 3trd ALPHA/BETA HYDROLASE
(Coxiella
burnetii) 		5 / 9 VAL A 119
VAL A  95
ILE A  32
ILE A 104
GLN A 123
 None
 1.27A 3hgxB-3trdA:
undetectable		 3hgxB-3trdA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B302_2
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 3trd ALPHA/BETA HYDROLASE
(Coxiella
burnetii) 		3 / 3 CYH A  34
PRO A  38
ASP A  87
 None
 0.89A 3hlwB-3trdA:
undetectable		 3hlwB-3trdA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_A_SAMA220_0
(16S RRNA METHYLASE)		 3trd ALPHA/BETA HYDROLASE
(Coxiella
burnetii) 		5 / 12 GLY A 108
GLY A 112
LEU A 106
THR A  51
LEU A  52
 None
 1.14A 3mteA-3trdA:
2.4		 3mteA-3trdA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_B_SAMB6735_0
(16S RRNA METHYLASE)		 3trd ALPHA/BETA HYDROLASE
(Coxiella
burnetii) 		5 / 12 GLY A 108
GLY A 112
LEU A 106
THR A  51
LEU A  52
 None
 1.04A 3p2kB-3trdA:
2.5		 3p2kB-3trdA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PM5_A_CE3A301_2
(BETA-LACTAMASE
CTX-M-14)		 3trd ALPHA/BETA HYDROLASE
(Coxiella
burnetii) 		3 / 3 CYH A  34
PRO A  38
ASP A  87
 None
 0.90A 4pm5A-3trdA:
undetectable		 4pm5A-3trdA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_1
(TUBULIN BETA CHAIN)		 3trd ALPHA/BETA HYDROLASE
(Coxiella
burnetii) 		5 / 12 VAL A 166
LEU A 200
LEU A 204
ALA A 132
LEU A 196
 None
 1.04A 6ew0B-3trdA:
3.4		 6ew0B-3trdA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_1
(TUBULIN BETA CHAIN)		 3trd ALPHA/BETA HYDROLASE
(Coxiella
burnetii) 		5 / 12 VAL A 166
LEU A 200
LEU A 204
ALA A 132
LEU A 196
 None
 1.04A 6ew0D-3trdA:
3.4		 6ew0D-3trdA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_1
(TUBULIN BETA CHAIN)		 3trd ALPHA/BETA HYDROLASE
(Coxiella
burnetii) 		5 / 12 VAL A 166
LEU A 200
LEU A 204
ALA A 132
LEU A 196
 None
 1.04A 6ew0H-3trdA:
3.4		 6ew0H-3trdA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_1
(TUBULIN BETA CHAIN)		 3trd ALPHA/BETA HYDROLASE
(Coxiella
burnetii) 		5 / 12 VAL A 166
LEU A 200
LEU A 204
ALA A 132
LEU A 196
 None
 1.04A 6ew0I-3trdA:
3.4		 6ew0I-3trdA:
18.38