SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3trp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		 3trp CALSEQUESTRIN-1
(Oryctolagus
cuniculus) 		4 / 8 PRO A 334
GLU A 338
GLU A 344
ASP A 345
 None
None
MRD  A 354 (-4.2A)
None
 1.25A 1dtlA-3trpA:
undetectable		 1dtlA-3trpA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_A_DVAA6_0
(GRAMICIDIN A)		 3trp CALSEQUESTRIN-1
(Oryctolagus
cuniculus) 		3 / 3 ALA A 320
VAL A 317
TRP A 242
 MRD  A 355 ( 3.9A)
None
MRD  A 355 (-4.0A)
 0.96A 1magA-3trpA:
undetectable		 1magA-3trpA:
3.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_B_DVAB6_0
(GRAMICIDIN A)		 3trp CALSEQUESTRIN-1
(Oryctolagus
cuniculus) 		3 / 3 ALA A 320
VAL A 317
TRP A 242
 MRD  A 355 ( 3.9A)
None
MRD  A 355 (-4.0A)
 0.96A 1magB-3trpA:
undetectable		 1magB-3trpA:
3.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_C_H4BC1002_1
(HYPOTHETICAL PROTEIN
PH0634)		 3trp CALSEQUESTRIN-1
(Oryctolagus
cuniculus) 		4 / 6 ASP A 291
THR A 114
GLU A 109
GLU A 117
 None
None
CA  A 362 (-2.7A)
None
 1.22A 2dttB-3trpA:
undetectable
2dttC-3trpA:
undetectable		 2dttB-3trpA:
15.79
2dttC-3trpA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO4_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 3trp CALSEQUESTRIN-1
(Oryctolagus
cuniculus) 		5 / 12 LEU A  58
ILE A  57
ALA A  34
VAL A  97
THR A 114
 None
 1.32A 2qo4A-3trpA:
undetectable		 2qo4A-3trpA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO6_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 3trp CALSEQUESTRIN-1
(Oryctolagus
cuniculus) 		5 / 12 LEU A  58
ILE A  57
ALA A  34
VAL A  97
THR A 114
 None
 1.33A 2qo6A-3trpA:
undetectable		 2qo6A-3trpA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_D_SALD1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3trp CALSEQUESTRIN-1
(Oryctolagus
cuniculus) 		5 / 12 GLY A 150
LEU A 190
PHE A 139
PRO A 205
ILE A 149
 None
 1.12A 2y7kD-3trpA:
undetectable		 2y7kD-3trpA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD393_1
(TETX2 PROTEIN)		 3trp CALSEQUESTRIN-1
(Oryctolagus
cuniculus) 		4 / 5 ILE A 104
ILE A 174
TYR A 173
GLU A 145
 None
None
None
NA  A 365 ( 4.6A)
 1.03A 4a99D-3trpA:
0.7		 4a99D-3trpA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1479_0
(MJ0495-LIKE PROTEIN)		 3trp CALSEQUESTRIN-1
(Oryctolagus
cuniculus) 		4 / 5 THR A 207
ILE A 208
GLU A 217
PHE A 152
 None
None
CA  A 358 (-2.3A)
None
 1.33A 4ac9C-3trpA:
undetectable		 4ac9C-3trpA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGZ_A_SPRA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3trp CALSEQUESTRIN-1
(Oryctolagus
cuniculus) 		5 / 9 LEU A  33
ILE A  16
ILE A  95
GLU A 105
VAL A 103
 None
 1.28A 5igzA-3trpA:
undetectable		 5igzA-3trpA:
20.72