SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3trr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1498_1
(CYTOCHROME P450 3A4)		 3trr PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE
(Mycobacteroides
abscessus) 		5 / 9 LEU A 109
ILE A 124
ALA A 102
GLY A  80
LEU A  81
 None
 1.11A 2v0mB-3trrA:
undetectable		 2v0mB-3trrA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 3trr PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE
(Mycobacteroides
abscessus) 		5 / 12 ALA A 188
PRO A  91
ALA A  39
PRO A  88
PHE A  83
 None
 1.15A 2zifB-3trrA:
undetectable		 2zifB-3trrA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA402_1
(HIV-1 PROTEASE)		 3trr PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE
(Mycobacteroides
abscessus) 		4 / 5 LEU A 153
PRO A 146
VAL A 149
ASP A 164
 None
 1.14A 3ufnA-3trrA:
undetectable
3ufnB-3trrA:
undetectable		 3ufnA-3trrA:
17.55
3ufnB-3trrA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3trr PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE
(Mycobacteroides
abscessus) 		5 / 9 ALA A 120
ALA A 100
VAL A 175
GLY A 178
ALA A 180
 None
 1.13A 4qvnK-3trrA:
undetectable
4qvnL-3trrA:
undetectable		 4qvnK-3trrA:
22.73
4qvnL-3trrA:
25.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3trr PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE
(Mycobacteroides
abscessus) 		5 / 9 ALA A 120
ALA A 100
VAL A 175
GLY A 178
ALA A 180
 None
 1.13A 4qvnY-3trrA:
undetectable
4qvnZ-3trrA:
undetectable		 4qvnY-3trrA:
22.73
4qvnZ-3trrA:
25.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0R_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 3trr PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE
(Mycobacteroides
abscessus) 		5 / 12 LEU A  14
ILE A  16
LEU A  35
ILE A  53
ILE A  92
 None
 1.03A 4y0rA-3trrA:
undetectable		 4y0rA-3trrA:
25.32