SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ts0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1NV8_A_SAMA300_0 (HEMK PROTEIN)	3ts0	PROTEIN LIN-28 HOMOLOG A (Mus musculus)	5 / 12	ILE A 43 GLY A 42 GLY A 40 THR A 59 PRO A 112	None	1.05A	1nv8A-3ts0A: undetectable	1nv8A-3ts0A: 19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1NV8_B_SAMB301_0 (HEMK PROTEIN)	3ts0	PROTEIN LIN-28 HOMOLOG A (Mus musculus)	5 / 12	ILE A 43 GLY A 42 GLY A 40 THR A 59 PRO A 112	None	1.06A	1nv8B-3ts0A: undetectable	1nv8B-3ts0A: 19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2C8A_B_NCAB1246_0 (MONO-ADP-RIBOSYLTRAN SFERASE C3)	3ts0	PROTEIN LIN-28 HOMOLOG A (Mus musculus)	4 / 7	ARG A 85 GLY A 83 SER A 86 PHE A 84	G U 7 ( 3.3A) None None A U 6 ( 3.3A)	1.05A	2c8aB-3ts0A: undetectable	2c8aB-3ts0A: 20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2C8A_D_NCAD1247_0 (MONO-ADP-RIBOSYLTRAN SFERASE C3)	3ts0	PROTEIN LIN-28 HOMOLOG A (Mus musculus)	4 / 7	ARG A 85 GLY A 83 SER A 86 PHE A 84	G U 7 ( 3.3A) None None A U 6 ( 3.3A)	0.98A	2c8aD-3ts0A: undetectable	2c8aD-3ts0A: 20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RRW_A_LURA705_1 (PROSTAGLANDIN G/H SYNTHASE 2)	3ts0	PROTEIN LIN-28 HOMOLOG A (Mus musculus)	5 / 12	LEU A 66 VAL A 64 GLY A 63 ALA A 62 LEU A 38	None	1.12A	4rrwA-3ts0A: undetectable	4rrwA-3ts0A: 12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RRW_B_LURB705_1 (PROSTAGLANDIN G/H SYNTHASE 2)	3ts0	PROTEIN LIN-28 HOMOLOG A (Mus musculus)	5 / 12	LEU A 66 VAL A 64 GLY A 63 ALA A 62 LEU A 38	None	1.11A	4rrwB-3ts0A: undetectable	4rrwB-3ts0A: 12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RRZ_A_LURA705_1 (PROSTAGLANDIN G/H SYNTHASE 2)	3ts0	PROTEIN LIN-28 HOMOLOG A (Mus musculus)	5 / 12	LEU A 66 VAL A 64 GLY A 63 ALA A 62 LEU A 38	None	1.12A	4rrzA-3ts0A: undetectable	4rrzA-3ts0A: 12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RRZ_B_LURB705_1 (PROSTAGLANDIN G/H SYNTHASE 2)	3ts0	PROTEIN LIN-28 HOMOLOG A (Mus musculus)	5 / 12	LEU A 66 VAL A 64 GLY A 63 ALA A 62 LEU A 38	None	1.11A	4rrzB-3ts0A: undetectable	4rrzB-3ts0A: 12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4UCI_B_ADNB2415_1 (RNA-DIRECTED RNA POLYMERASE L)	3ts0	PROTEIN LIN-28 HOMOLOG A (Mus musculus)	4 / 7	GLU A 94 PHE A 95 PHE A 97 HIS A 39	None	1.21A	4uciB-3ts0A: undetectable	4uciB-3ts0A: 17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6NKN_J_CHDJ101_0 (CYTOCHROME C OXIDASE SUBUNIT 3 CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	3ts0	PROTEIN LIN-28 HOMOLOG A (Mus musculus)	3 / 3	ARG A 85 PHE A 53 PHE A 84	G U 7 ( 3.3A) A U 10 ( 4.1A) A U 6 ( 3.3A)	0.93A	6nknC-3ts0A: undetectable 6nknJ-3ts0A: undetectable	6nknC-3ts0A: 17.10 6nknJ-3ts0A: 17.81

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1NV8_A_SAMA300_0","HEMK PROTEIN","3ts0","PROTEIN LIN-28 HOMOLOG A","Mus musculus",5,"ILE A  43;GLY A  42;GLY A  40;THR A  59;PRO A 112","None","1.05A","1nv8A-3ts0A:undetectable","1nv8A-3ts0A:19.05"],["1NV8_B_SAMB301_0","HEMK PROTEIN","3ts0","PROTEIN LIN-28 HOMOLOG A","Mus musculus",5,"ILE A  43;GLY A  42;GLY A  40;THR A  59;PRO A 112","None","1.06A","1nv8B-3ts0A:undetectable","1nv8B-3ts0A:19.05"],["2C8A_B_NCAB1246_0","MONO-ADP-RIBOSYLTRANSFERASE C3","3ts0","PROTEIN LIN-28 HOMOLOG A","Mus musculus",4,"ARG A  85;GLY A  83;SER A  86;PHE A  84","  G U   7 ( 3.3A);None;None;  A U   6 ( 3.3A)","1.05A","2c8aB-3ts0A:undetectable","2c8aB-3ts0A:20.27"],["2C8A_D_NCAD1247_0","MONO-ADP-RIBOSYLTRANSFERASE C3","3ts0","PROTEIN LIN-28 HOMOLOG A","Mus musculus",4,"ARG A  85;GLY A  83;SER A  86;PHE A  84","  G U   7 ( 3.3A);None;None;  A U   6 ( 3.3A)","0.98A","2c8aD-3ts0A:undetectable","2c8aD-3ts0A:20.27"],["4RRW_A_LURA705_1","PROSTAGLANDIN G\/H SYNTHASE 2","3ts0","PROTEIN LIN-28 HOMOLOG A","Mus musculus",5,"LEU A  66;VAL A  64;GLY A  63;ALA A  62;LEU A  38","None","1.12A","4rrwA-3ts0A:undetectable","4rrwA-3ts0A:12.78"],["4RRW_B_LURB705_1","PROSTAGLANDIN G\/H SYNTHASE 2","3ts0","PROTEIN LIN-28 HOMOLOG A","Mus musculus",5,"LEU A  66;VAL A  64;GLY A  63;ALA A  62;LEU A  38","None","1.11A","4rrwB-3ts0A:undetectable","4rrwB-3ts0A:12.78"],["4RRZ_A_LURA705_1","PROSTAGLANDIN G\/H SYNTHASE 2","3ts0","PROTEIN LIN-28 HOMOLOG A","Mus musculus",5,"LEU A  66;VAL A  64;GLY A  63;ALA A  62;LEU A  38","None","1.12A","4rrzA-3ts0A:undetectable","4rrzA-3ts0A:12.78"],["4RRZ_B_LURB705_1","PROSTAGLANDIN G\/H SYNTHASE 2","3ts0","PROTEIN LIN-28 HOMOLOG A","Mus musculus",5,"LEU A  66;VAL A  64;GLY A  63;ALA A  62;LEU A  38","None","1.11A","4rrzB-3ts0A:undetectable","4rrzB-3ts0A:12.78"],["4UCI_B_ADNB2415_1","RNA-DIRECTED RNA POLYMERASE L","3ts0","PROTEIN LIN-28 HOMOLOG A","Mus musculus",4,"GLU A  94;PHE A  95;PHE A  97;HIS A  39","None","1.21A","4uciB-3ts0A:undetectable","4uciB-3ts0A:17.05"],["6NKN_J_CHDJ101_0","CYTOCHROME C OXIDASE SUBUNIT 3;CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL","3ts0","PROTEIN LIN-28 HOMOLOG A","Mus musculus",3,"ARG A  85;PHE A  53;PHE A  84","  G U   7 ( 3.3A);  A U  10 ( 4.1A);  A U   6 ( 3.3A)","0.93A","6nknC-3ts0A:undetectable;6nknJ-3ts0A:undetectable","6nknC-3ts0A:17.10;6nknJ-3ts0A:17.81"]]