SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tsc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AEG_A_4APA296_1
(CYTOCHROME C
PEROXIDASE)		 3tsc PUTATIVE
OXIDOREDUCTASE
(Mycobacterium
avium) 		4 / 8 HIS A 191
GLY A 146
GLY A 149
LEU A 188
 None
 0.79A 1aegA-3tscA:
undetectable		 1aegA-3tscA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RI4_A_SAMA299_0
(MRNA CAPPING ENZYME)		 3tsc PUTATIVE
OXIDOREDUCTASE
(Mycobacterium
avium) 		5 / 12 GLY A  14
ILE A  39
ALA A  40
ASP A  77
GLN A  19
 NAD  A 274 (-3.2A)
NAD  A 274 (-3.8A)
None
NAD  A 274 (-3.4A)
NAD  A 274 (-3.3A)
 1.15A 1ri4A-3tscA:
6.2		 1ri4A-3tscA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T87_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 3tsc PUTATIVE
OXIDOREDUCTASE
(Mycobacterium
avium) 		4 / 7 THR A  78
LEU A  84
VAL A  87
ASP A  38
 NAD  A 274 (-3.4A)
None
None
NAD  A 274 (-2.9A)
 1.02A 1t87A-3tscA:
undetectable		 1t87A-3tscA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAY_A_ADNA1001_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 3tsc PUTATIVE
OXIDOREDUCTASE
(Mycobacterium
avium) 		6 / 11 GLY A  14
ALA A  16
ASP A  38
ASP A  77
ALA A 105
VAL A 107
 NAD  A 274 (-3.2A)
NAD  A 274 ( 3.9A)
NAD  A 274 (-2.9A)
NAD  A 274 (-3.4A)
NAD  A 274 (-3.5A)
NAD  A 274 ( 4.9A)
 0.28A 1uayA-3tscA:
28.7		 1uayA-3tscA:
29.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAY_B_ADNB1002_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 3tsc PUTATIVE
OXIDOREDUCTASE
(Mycobacterium
avium) 		6 / 10 GLY A  14
ALA A  16
ASP A  38
ASP A  77
ALA A 105
VAL A 107
 NAD  A 274 (-3.2A)
NAD  A 274 ( 3.9A)
NAD  A 274 (-2.9A)
NAD  A 274 (-3.4A)
NAD  A 274 (-3.5A)
NAD  A 274 ( 4.9A)
 0.29A 1uayB-3tscA:
29.2		 1uayB-3tscA:
29.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3tsc PUTATIVE
OXIDOREDUCTASE
(Mycobacterium
avium) 		5 / 12 GLY A  14
ASP A  38
ASP A  77
ASN A 104
ALA A 105
 NAD  A 274 (-3.2A)
NAD  A 274 (-2.9A)
NAD  A 274 (-3.4A)
NAD  A 274 (-3.2A)
NAD  A 274 (-3.5A)
 0.94A 2bm9E-3tscA:
4.6		 2bm9E-3tscA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3tsc PUTATIVE
OXIDOREDUCTASE
(Mycobacterium
avium) 		4 / 5 PRO A  48
PRO A  44
ILE A 127
TYR A  49
 None
None
NAD  A 274 (-3.8A)
NAD  A 274 ( 4.8A)
 1.04A 2jkjD-3tscA:
undetectable		 2jkjD-3tscA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3tsc PUTATIVE
OXIDOREDUCTASE
(Mycobacterium
avium) 		4 / 5 PRO A  48
PRO A  44
ILE A 127
TYR A  49
 None
None
NAD  A 274 (-3.8A)
NAD  A 274 ( 4.8A)
 1.05A 2jkjF-3tscA:
undetectable		 2jkjF-3tscA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_D_TOPD1158_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 3tsc PUTATIVE
OXIDOREDUCTASE
(Mycobacterium
avium) 		5 / 10 ILE A 193
ALA A 185
LEU A 154
ILE A 152
THR A 260
 None
 1.21A 2w9sD-3tscA:
undetectable		 2w9sD-3tscA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_F_TOPF1159_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 3tsc PUTATIVE
OXIDOREDUCTASE
(Mycobacterium
avium) 		5 / 10 ILE A 193
ALA A 185
LEU A 154
ILE A 152
THR A 260
 None
 1.22A 2w9sF-3tscA:
undetectable		 2w9sF-3tscA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 3tsc PUTATIVE
OXIDOREDUCTASE
(Mycobacterium
avium) 		4 / 8 ILE A 155
ASN A 128
SER A 173
SER A 157
 NAD  A 274 (-4.6A)
None
None
NAD  A 274 (-3.6A)
 1.06A 2zw9B-3tscA:
2.5		 2zw9B-3tscA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_B_VDYB6178_1
(VITAMIN D
HYDROXYLASE)		 3tsc PUTATIVE
OXIDOREDUCTASE
(Mycobacterium
avium) 		5 / 12 THR A 247
LEU A 251
ILE A 155
THR A 132
VAL A 136
 None
None
NAD  A 274 (-4.6A)
None
None
 1.27A 3a51B-3tscA:
undetectable		 3a51B-3tscA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_A_ADNA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 3tsc PUTATIVE
OXIDOREDUCTASE
(Mycobacterium
avium) 		5 / 10 ASP A  38
ILE A  39
ALA A  52
ASP A  77
VAL A  76
 NAD  A 274 (-2.9A)
NAD  A 274 (-3.8A)
NAD  A 274 (-3.5A)
NAD  A 274 (-3.4A)
None
 1.41A 3ay0A-3tscA:
undetectable		 3ay0A-3tscA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJ8_C_SPMC500_1
(DIAMINE
ACETYLTRANSFERASE 1)		 3tsc PUTATIVE
OXIDOREDUCTASE
(Mycobacterium
avium) 		4 / 6 ASP A  77
LEU A  84
ASP A  38
LEU A  57
 NAD  A 274 (-3.4A)
None
NAD  A 274 (-2.9A)
None
 1.27A 3bj8C-3tscA:
1.2
3bj8D-3tscA:
undetectable		 3bj8C-3tscA:
19.00
3bj8D-3tscA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3tsc PUTATIVE
OXIDOREDUCTASE
(Mycobacterium
avium) 		4 / 6 VAL A 102
ILE A 244
ILE A 153
LEU A 154
 None
 0.72A 3hegA-3tscA:
undetectable		 3hegA-3tscA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 3tsc PUTATIVE
OXIDOREDUCTASE
(Mycobacterium
avium) 		3 / 3 ARG A 148
ASP A 254
ASP A  99
 None
 0.73A 3jayA-3tscA:
undetectable		 3jayA-3tscA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 3tsc PUTATIVE
OXIDOREDUCTASE
(Mycobacterium
avium) 		3 / 3 ARG A 148
ASP A 254
ASP A  99
 None
 0.75A 3jb2A-3tscA:
3.0		 3jb2A-3tscA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 3tsc PUTATIVE
OXIDOREDUCTASE
(Mycobacterium
avium) 		3 / 3 ARG A 148
ASP A 254
ASP A  99
 None
 0.87A 3jb3A-3tscA:
3.5		 3jb3A-3tscA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_C_9PLC1_1
(CYTOCHROME P450 2A13)		 3tsc PUTATIVE
OXIDOREDUCTASE
(Mycobacterium
avium) 		4 / 7 PHE A  11
ALA A 103
THR A  13
LEU A  84
 None
 0.83A 3t3sC-3tscA:
undetectable		 3t3sC-3tscA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HXY_B_ACAB502_1
(PLM1)		 3tsc PUTATIVE
OXIDOREDUCTASE
(Mycobacterium
avium) 		4 / 7 SER A 157
GLN A 164
TYR A 170
MET A 207
 NAD  A 274 (-3.6A)
None
NAD  A 274 (-4.9A)
NAD  A 274 (-3.6A)
 1.06A 4hxyB-3tscA:
19.4		 4hxyB-3tscA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_A_SAMA401_0
(METHYLTRANSFERASE
MPPJ)		 3tsc PUTATIVE
OXIDOREDUCTASE
(Mycobacterium
avium) 		5 / 12 GLY A 131
ILE A 127
ALA A 105
PHE A  81
ASP A  77
 None
NAD  A 274 (-3.8A)
NAD  A 274 (-3.5A)
None
NAD  A 274 (-3.4A)
 1.13A 4kicA-3tscA:
6.0		 4kicA-3tscA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_A_RTZA602_1
(CYTOCHROME P450 2D6)		 3tsc PUTATIVE
OXIDOREDUCTASE
(Mycobacterium
avium) 		5 / 12 GLY A 179
LEU A 180
VAL A 129
THR A 130
PHE A 184
 None
 1.10A 4wnwA-3tscA:
undetectable		 4wnwA-3tscA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_2
(CYP51 VARIANT1)		 3tsc PUTATIVE
OXIDOREDUCTASE
(Mycobacterium
avium) 		3 / 3 PRO A 165
ILE A 155
SER A 227
 None
NAD  A 274 (-4.6A)
None
 0.79A 5fsaA-3tscA:
undetectable		 5fsaA-3tscA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA605_1
(CHITINASE)		 3tsc PUTATIVE
OXIDOREDUCTASE
(Mycobacterium
avium) 		3 / 3 TRP A 250
ILE A 153
SER A 151
 None
 0.91A 5gqbA-3tscA:
3.3		 5gqbA-3tscA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_A_ROCA101_1
(PROTEASE PR5-SQV)		 3tsc PUTATIVE
OXIDOREDUCTASE
(Mycobacterium
avium) 		5 / 9 ALA A 245
ASP A 246
ASP A 243
THR A 205
PRO A 206
 None
None
None
NAD  A 274 (-2.8A)
NAD  A 274 (-3.9A)
 1.27A 5kr2A-3tscA:
undetectable		 5kr2A-3tscA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_A_CXQA507_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 3tsc PUTATIVE
OXIDOREDUCTASE
(Mycobacterium
avium) 		4 / 5 ARG A 182
ALA A 181
GLN A 263
ILE A 264
 None
 1.28A 6f6sA-3tscA:
undetectable
6f6sB-3tscA:
undetectable		 6f6sA-3tscA:
18.22
6f6sB-3tscA:
21.43