SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tsm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q0Y_H_MOIH401_1
(FAB 9B1, HEAVY CHAIN
FAB 9B1, LIGHT CHAIN)		 3tsm INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Brucella
abortus) 		4 / 7 GLU A 222
GLU A 171
ILE A 145
LEU A 120
 None
 1.48A 1q0yH-3tsmA:
undetectable
1q0yL-3tsmA:
undetectable		 1q0yH-3tsmA:
19.16
1q0yL-3tsmA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A5H_A_SAMA417_0
(L-LYSINE
2,3-AMINOMUTASE)		 3tsm INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Brucella
abortus) 		5 / 11 HIS A 228
THR A 227
CYH A 231
ASP A 230
LEU A 261
 None
 1.42A 2a5hA-3tsmA:
3.4		 2a5hA-3tsmA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A5H_B_SAMB417_0
(L-LYSINE
2,3-AMINOMUTASE)		 3tsm INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Brucella
abortus) 		5 / 12 HIS A 228
THR A 227
CYH A 231
ASP A 230
LEU A 261
 None
 1.42A 2a5hB-3tsmA:
2.8		 2a5hB-3tsmA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A5H_C_SAMC417_0
(L-LYSINE
2,3-AMINOMUTASE)		 3tsm INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Brucella
abortus) 		5 / 12 HIS A 228
THR A 227
CYH A 231
ASP A 230
LEU A 261
 None
 1.41A 2a5hC-3tsmA:
2.8		 2a5hC-3tsmA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A5H_D_SAMD417_0
(L-LYSINE
2,3-AMINOMUTASE)		 3tsm INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Brucella
abortus) 		5 / 12 HIS A 228
THR A 227
CYH A 231
ASP A 230
LEU A 261
 None
 1.43A 2a5hD-3tsmA:
3.3		 2a5hD-3tsmA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 3tsm INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Brucella
abortus) 		4 / 5 LEU A 209
ALA A 213
LEU A 182
MET A 146
 None
 0.92A 2oaxA-3tsmA:
undetectable		 2oaxA-3tsmA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_NIMA300_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 3tsm INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Brucella
abortus) 		4 / 5 LEU A  95
ALA A  64
ILE A  71
LYS A 122
 None
 1.06A 2othA-3tsmA:
undetectable		 2othA-3tsmA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P02_A_SAMA2_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-2)		 3tsm INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Brucella
abortus) 		4 / 8 PRO A  99
ASP A  97
SER A 148
PHE A 124
 None
 1.11A 2p02A-3tsmA:
undetectable		 2p02A-3tsmA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I9J_B_NCAB302_0
(ADP-RIBOSYL CYCLASE)		 3tsm INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Brucella
abortus) 		4 / 6 LEU A 243
GLU A 222
ASN A 192
SER A  93
 None
 1.32A 3i9jB-3tsmA:
undetectable		 3i9jB-3tsmA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD202_1
(PROTEIN S100-A4)		 3tsm INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Brucella
abortus) 		5 / 11 GLU A 158
ASP A 167
LEU A 184
SER A 185
ILE A 170
 None
 1.48A 3ko0C-3tsmA:
undetectable
3ko0D-3tsmA:
undetectable
3ko0E-3tsmA:
undetectable
3ko0F-3tsmA:
undetectable		 3ko0C-3tsmA:
17.54
3ko0D-3tsmA:
17.54
3ko0E-3tsmA:
17.54
3ko0F-3tsmA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIX_A_NIMA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 3tsm INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Brucella
abortus) 		4 / 4 LEU A  95
ALA A  64
ILE A  71
LYS A 122
 None
 1.12A 4eixA-3tsmA:
undetectable		 4eixA-3tsmA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3tsm INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Brucella
abortus) 		4 / 8 PRO A  99
ASP A  97
SER A 148
PHE A 124
 None
 1.17A 4kttA-3tsmA:
undetectable		 4kttA-3tsmA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3tsm INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Brucella
abortus) 		4 / 8 PRO A  99
ASP A  97
SER A 148
PHE A 124
 None
 1.13A 4kttC-3tsmA:
undetectable		 4kttC-3tsmA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3tsm INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Brucella
abortus) 		4 / 8 PRO A  99
ASP A  97
SER A 148
PHE A 124
 None
 1.14A 4ndnA-3tsmA:
undetectable		 4ndnA-3tsmA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3tsm INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Brucella
abortus) 		4 / 7 PRO A  99
ASP A  97
SER A 148
PHE A 124
 None
 1.16A 4ndnC-3tsmA:
undetectable		 4ndnC-3tsmA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODJ_A_SAMA500_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 3tsm INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Brucella
abortus) 		4 / 7 PRO A  99
ASP A  97
SER A 148
PHE A 124
 None
 1.08A 4odjA-3tsmA:
undetectable		 4odjA-3tsmA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_B_DIFB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3tsm INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Brucella
abortus) 		4 / 8 ILE A 225
SER A  93
LEU A 169
LEU A 188
 None
 0.76A 4xtaB-3tsmA:
undetectable		 4xtaB-3tsmA:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_ADNA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3tsm INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Brucella
abortus) 		4 / 8 PRO A  99
ASP A  97
SER A 148
PHE A 124
 None
 1.12A 5a1iA-3tsmA:
undetectable		 5a1iA-3tsmA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3tsm INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Brucella
abortus) 		4 / 7 PRO A  99
ASP A  97
SER A 148
PHE A 124
 None
 1.12A 5a1iA-3tsmA:
undetectable		 5a1iA-3tsmA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3tsm INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Brucella
abortus) 		5 / 12 GLY A  41
ALA A  56
LEU A 218
ILE A  58
THR A 241
 None
 0.79A 5hieA-3tsmA:
undetectable		 5hieA-3tsmA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3tsm INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Brucella
abortus) 		5 / 12 GLY A  41
ALA A  56
LEU A 218
ILE A  58
THR A 241
 None
 0.80A 5hieB-3tsmA:
undetectable		 5hieB-3tsmA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3tsm INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Brucella
abortus) 		5 / 12 GLY A  41
ALA A  56
LEU A 218
ILE A  58
THR A 241
 None
 0.78A 5hieD-3tsmA:
undetectable		 5hieD-3tsmA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 3tsm INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Brucella
abortus) 		5 / 12 GLY A 221
LEU A 209
ALA A 213
GLY A 238
SER A 237
 None
 1.16A 5jglB-3tsmA:
undetectable		 5jglB-3tsmA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFP_A_8W5A804_2
(GLUCOCORTICOID
RECEPTOR)		 3tsm INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Brucella
abortus) 		4 / 4 LEU A 209
MET A 146
ILE A 239
LEU A 189
 None
 1.34A 5nfpA-3tsmA:
undetectable		 5nfpA-3tsmA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3tsm INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Brucella
abortus) 		4 / 8 PRO A  99
ASP A  97
SER A 148
PHE A 124
 None
 1.15A 6fbnB-3tsmA:
undetectable		 6fbnB-3tsmA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBO_A_ADNA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3tsm INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Brucella
abortus) 		4 / 8 PRO A  99
ASP A  97
SER A 148
PHE A 124
 None
 1.12A 6fboA-3tsmA:
undetectable		 6fboA-3tsmA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCB_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3tsm INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Brucella
abortus) 		4 / 8 PRO A  99
ASP A  97
SER A 148
PHE A 124
 None
 1.12A 6fcbA-3tsmA:
undetectable		 6fcbA-3tsmA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCD_A_ADNA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3tsm INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Brucella
abortus) 		4 / 8 PRO A  99
ASP A  97
SER A 148
PHE A 124
 None
 1.11A 6fcdA-3tsmA:
undetectable		 6fcdA-3tsmA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G6R_A_SAMA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3tsm INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Brucella
abortus) 		4 / 7 PRO A  99
ASP A  97
SER A 148
PHE A 124
 None
 1.12A 6g6rA-3tsmA:
undetectable		 6g6rA-3tsmA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 3tsm INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Brucella
abortus) 		5 / 12 GLY A 190
ALA A 154
ASP A 159
PHE A 162
PHE A  42
 None
 0.84A 6nj9K-3tsmA:
undetectable		 6nj9K-3tsmA:
21.79