SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tso'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3N62_B_ACTB860_0 (NITRIC OXIDE SYNTHASE)	3tso	RAS-RELATED PROTEIN RAB-25 (Homo sapiens)	3 / 3	GLY A 84 TRP A 66 VAL A 16	None	0.77A	3n62B-3tsoA: undetectable	3n62B-3tsoA: 17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3N65_B_ACTB860_0 (NITRIC OXIDE SYNTHASE)	3tso	RAS-RELATED PROTEIN RAB-25 (Homo sapiens)	3 / 3	GLY A 84 TRP A 66 VAL A 16	None	0.76A	3n65B-3tsoA: undetectable	3n65B-3tsoA: 17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4L78_A_ACTA1327_0 (PHOSPHORIBOSYLFORMYL GLYCINAMIDINE SYNTHASE)	3tso	RAS-RELATED PROTEIN RAB-25 (Homo sapiens)	4 / 4	VAL A 135 THR A 137 GLU A 139 GLU A 138	None	1.36A	4l78A-3tsoA: undetectable	4l78A-3tsoA: 8.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HIK_A_SAMA301_0 (GLYCINE SARCOSINE N-METHYLTRANSFERASE)	3tso	RAS-RELATED PROTEIN RAB-25 (Homo sapiens)	5 / 12	GLY A 24 GLY A 70 SER A 21 ARG A 105 GLY A 124	GNP A 201 (-3.2A) GNP A 201 (-3.8A) GNP A 201 (-2.4A) None None	1.16A	5hikA-3tsoA: 2.5	5hikA-3tsoA: 22.89

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3N62_B_ACTB860_0","NITRIC OXIDE SYNTHASE","3tso","RAS-RELATED PROTEIN RAB-25","Homo sapiens",3,"GLY A  84;TRP A  66;VAL A  16","None","0.77A","3n62B-3tsoA:undetectable","3n62B-3tsoA:17.02"],["3N65_B_ACTB860_0","NITRIC OXIDE SYNTHASE","3tso","RAS-RELATED PROTEIN RAB-25","Homo sapiens",3,"GLY A  84;TRP A  66;VAL A  16","None","0.76A","3n65B-3tsoA:undetectable","3n65B-3tsoA:17.02"],["4L78_A_ACTA1327_0","PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE","3tso","RAS-RELATED PROTEIN RAB-25","Homo sapiens",4,"VAL A 135;THR A 137;GLU A 139;GLU A 138","None","1.36A","4l78A-3tsoA:undetectable","4l78A-3tsoA:8.84"],["5HIK_A_SAMA301_0","GLYCINE SARCOSINE N-METHYLTRANSFERASE","3tso","RAS-RELATED PROTEIN RAB-25","Homo sapiens",5,"GLY A  24;GLY A  70;SER A  21;ARG A 105;GLY A 124","GNP A 201 (-3.2A);GNP A 201 (-3.8A);GNP A 201 (-2.4A);None;None","1.16A","5hikA-3tsoA:2.5","5hikA-3tsoA:22.89"]]