SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tsr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DY5_A_ACTA600_0
(RIBONUCLEASE A)		 3tsr RIBONUCLEASE
PANCREATIC
(Mus
musculus) 		4 / 4 HIS A  13
VAL A  44
ASN A  45
THR A  46
 None
 0.36A 1dy5A-3tsrA:
22.9		 1dy5A-3tsrA:
68.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4001_1
(SERUM ALBUMIN)		 3tsr RIBONUCLEASE
INHIBITOR
(Mus
musculus) 		5 / 9 ASN E 403
LEU E 385
VAL E 410
GLY E 409
LEU E 429
 None
 1.24A 1e7aB-3tsrE:
undetectable		 1e7aB-3tsrE:
22.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1N3Z_A_ADNA126_1
(RIBONUCLEASE,
SEMINAL)		 3tsr RIBONUCLEASE
PANCREATIC
(Mus
musculus) 		7 / 9 ALA A   5
LYS A   8
ASN A  68
ASN A  72
ALA A 110
VAL A 119
HIS A 120
 None
 0.51A 1n3zA-3tsrA:
23.6		 1n3zA-3tsrA:
67.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_A_NOVA1300_1
(TOPOISOMERASE IV
SUBUNIT B)		 3tsr RIBONUCLEASE
INHIBITOR
RIBONUCLEASE
PANCREATIC
(Mus
musculus) 		5 / 12 ASN E 402
SER E 401
ASP E 374
ASP E 399
ASP A  97
 None
 1.37A 1s14A-3tsrE:
undetectable		 1s14A-3tsrE:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		 3tsr RIBONUCLEASE
INHIBITOR
RIBONUCLEASE
PANCREATIC
(Mus
musculus) 		5 / 12 ASN E 402
SER E 401
ASP E 374
ASP E 399
ASP A  97
 None
 1.39A 1s14B-3tsrE:
undetectable		 1s14B-3tsrE:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_A_NDRA1001_0
(PROGESTERONE
RECEPTOR)		 3tsr RIBONUCLEASE
INHIBITOR
(Mus
musculus) 		5 / 12 LEU E 224
LEU E 253
LEU E 281
LEU E 229
CYH E 215
 None
 1.49A 1sqnA-3tsrE:
undetectable		 1sqnA-3tsrE:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3tsr RIBONUCLEASE
INHIBITOR
(Mus
musculus) 		3 / 3 SER E  57
ASP E 117
CYH E 147
 None
 1.15A 2br4E-3tsrE:
undetectable		 2br4E-3tsrE:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_CCSB417_0
(ESTROGEN RECEPTOR)		 3tsr RIBONUCLEASE
PANCREATIC
(Mus
musculus) 		3 / 3 GLN A  61
LYS A  75
VAL A 109
 None
 0.92A 2jfaB-3tsrA:
undetectable		 2jfaB-3tsrA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 3tsr RIBONUCLEASE
PANCREATIC
(Mus
musculus) 		3 / 3 SER A  20
HIS A  13
ASP A 122
 None
 0.68A 2oxtA-3tsrA:
undetectable		 2oxtA-3tsrA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 3tsr RIBONUCLEASE
INHIBITOR
(Mus
musculus) 		5 / 12 LEU E 248
SER E 250
SER E 220
LEU E 229
LEU E 271
 None
 1.30A 2zlcA-3tsrE:
undetectable		 2zlcA-3tsrE:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA608_1
(CHITINASE A)		 3tsr RIBONUCLEASE
INHIBITOR
RIBONUCLEASE
PANCREATIC
(Mus
musculus) 		4 / 6 TRP E 434
ASN A  72
ALA A 110
HIS A 120
 None
 1.34A 3aruA-3tsrE:
2.3		 3aruA-3tsrE:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)		 3tsr RIBONUCLEASE
INHIBITOR
RIBONUCLEASE
PANCREATIC
(Mus
musculus) 		5 / 12 ASN E 402
SER E 401
ASP E 374
ASP E 399
ASP A  97
 None
 1.38A 3lpsA-3tsrE:
undetectable		 3lpsA-3tsrE:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE506_1
(HEMOLYTIC LECTIN
CEL-III)		 3tsr RIBONUCLEASE
INHIBITOR
(Mus
musculus) 		4 / 6 THR E 264
ASN E 236
GLY E 235
ASP E 262
 None
None
None
EDO  E 458 (-3.0A)
 1.38A 3w9tE-3tsrE:
undetectable		 3w9tE-3tsrE:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_A_SUZA201_1
(TRANSTHYRETIN)		 3tsr RIBONUCLEASE
INHIBITOR
(Mus
musculus) 		4 / 7 LEU E 370
LEU E 395
SER E 394
THR E 365
 None
 1.02A 4ikjA-3tsrE:
undetectable
4ikjB-3tsrE:
undetectable		 4ikjA-3tsrE:
15.23
4ikjB-3tsrE:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 3tsr RIBONUCLEASE
INHIBITOR
(Mus
musculus) 		5 / 12 LEU E  58
LEU E  63
ILE E  43
GLY E  34
LEU E  30
 None
None
None
EDO  E 459 ( 4.7A)
None
 0.93A 4lmnA-3tsrE:
undetectable		 4lmnA-3tsrE:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3tsr RIBONUCLEASE
INHIBITOR
RIBONUCLEASE
PANCREATIC
(Mus
musculus) 		3 / 3 LEU E 452
ARG E 453
MET A  36
 None
 0.77A 4m11C-3tsrE:
undetectable		 4m11C-3tsrE:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_2
(ADENOSINE KINASE)		 3tsr RIBONUCLEASE
INHIBITOR
(Mus
musculus) 		4 / 5 CYH E 300
LEU E 338
LEU E 370
LEU E 313
 None
 1.19A 4n09D-3tsrE:
undetectable		 4n09D-3tsrE:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA306_1
(CHITOSANASE)		 3tsr RIBONUCLEASE
INHIBITOR
RIBONUCLEASE
PANCREATIC
(Mus
musculus) 		3 / 3 SER E 401
ASP E 431
GLN A  12
 None
 0.62A 4oltA-3tsrE:
undetectable
4oltB-3tsrE:
undetectable		 4oltA-3tsrE:
19.17
4oltB-3tsrE:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB304_1
(CHITOSANASE)		 3tsr RIBONUCLEASE
INHIBITOR
RIBONUCLEASE
PANCREATIC
(Mus
musculus) 		3 / 3 GLN A  12
SER E 401
ASP E 431
 None
 0.60A 4qwpA-3tsrA:
undetectable
4qwpB-3tsrA:
undetectable		 4qwpA-3tsrA:
17.41
4qwpB-3tsrA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_1
(THYROXINE-BINDING
GLOBULIN)		 3tsr RIBONUCLEASE
INHIBITOR
(Mus
musculus) 		5 / 10 LEU E 398
LEU E 413
SER E 380
ASN E 403
LEU E 429
 None
 1.13A 4yiaA-3tsrE:
undetectable		 4yiaA-3tsrE:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZOW_A_CLMA500_0
(MULTIDRUG
TRANSPORTER MDFA)		 3tsr RIBONUCLEASE
INHIBITOR
(Mus
musculus) 		6 / 11 ASP E  31
LEU E  10
LEU E  85
LEU E  63
LEU E  35
LEU E  87
 None
 1.37A 4zowA-3tsrE:
undetectable		 4zowA-3tsrE:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_C_SORC1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3tsr RIBONUCLEASE
INHIBITOR
(Mus
musculus) 		5 / 7 ILE E 239
CYH E 261
LYS E 233
LEU E 234
GLY E 238
 None
None
EDO  E 458 (-3.5A)
None
None
 1.50A 5a06C-3tsrE:
2.7		 5a06C-3tsrE:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_I_IPHI101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 3tsr RIBONUCLEASE
INHIBITOR
(Mus
musculus) 		4 / 6 VAL E 160
LEU E 161
CYH E 137
LEU E 142
 None
 1.05A 5hrqB-3tsrE:
undetectable
5hrqI-3tsrE:
undetectable
5hrqJ-3tsrE:
undetectable		 5hrqB-3tsrE:
5.74
5hrqI-3tsrE:
9.57
5hrqJ-3tsrE:
5.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQB_A_KANA600_1
(BIFUNCTIONAL AAC/APH)		 3tsr RIBONUCLEASE
INHIBITOR
(Mus
musculus) 		5 / 12 GLU E 340
SER E 312
GLU E 283
GLU E 311
GLU E 369
 None
 1.39A 5iqbA-3tsrE:
undetectable		 5iqbA-3tsrE:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQB_D_KAND600_1
(BIFUNCTIONAL AAC/APH)		 3tsr RIBONUCLEASE
INHIBITOR
(Mus
musculus) 		5 / 12 GLU E 340
SER E 312
GLU E 283
GLU E 311
GLU E 369
 None
 1.35A 5iqbD-3tsrE:
undetectable		 5iqbD-3tsrE:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQE_D_NMYD600_1
(BIFUNCTIONAL AAC/APH)		 3tsr RIBONUCLEASE
INHIBITOR
(Mus
musculus) 		5 / 12 GLU E 340
SER E 312
GLU E 283
GLU E 311
GLU E 369
 None
 1.30A 5iqeD-3tsrE:
undetectable		 5iqeD-3tsrE:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3tsr RIBONUCLEASE
PANCREATIC
RIBONUCLEASE
INHIBITOR
(Mus
musculus;
Mus
musculus) 		4 / 5 ASN A  45
ASP E 431
ASN E 402
ASP E 399
 None
 1.40A 5vooA-3tsrA:
undetectable		 5vooA-3tsrA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3tsr RIBONUCLEASE
PANCREATIC
RIBONUCLEASE
INHIBITOR
(Mus
musculus;
Mus
musculus) 		4 / 5 ASN A  45
ASP E 431
ASN E 402
ASP E 399
 None
 1.39A 5vooC-3tsrA:
undetectable		 5vooC-3tsrA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3tsr RIBONUCLEASE
PANCREATIC
RIBONUCLEASE
INHIBITOR
(Mus
musculus;
Mus
musculus) 		4 / 5 ASN A  45
ASP E 431
ASN E 402
ASP E 399
 None
 1.45A 5vooE-3tsrA:
undetectable		 5vooE-3tsrA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0C_D_TA1D502_1
(TUBULIN BETA CHAIN)		 3tsr RIBONUCLEASE
INHIBITOR
(Mus
musculus) 		5 / 12 LEU E 142
LEU E 128
LEU E 144
GLY E 181
LEU E 177
 None
 0.86A 6b0cD-3tsrE:
undetectable		 6b0cD-3tsrE:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C5U_A_RIOA600_0
(BIFUNCTIONAL AAC/APH)		 3tsr RIBONUCLEASE
INHIBITOR
(Mus
musculus) 		5 / 10 GLU E 340
SER E 312
GLU E 283
GLU E 311
GLU E 369
 None
 1.30A 6c5uA-3tsrE:
0.0		 6c5uA-3tsrE:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C5U_B_RIOB600_0
(BIFUNCTIONAL AAC/APH)		 3tsr RIBONUCLEASE
INHIBITOR
(Mus
musculus) 		5 / 9 GLU E 340
SER E 312
GLU E 283
GLU E 311
GLU E 369
 None
 1.39A 6c5uB-3tsrE:
0.0		 6c5uB-3tsrE:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C5U_D_RIOD600_0
(BIFUNCTIONAL AAC/APH)		 3tsr RIBONUCLEASE
INHIBITOR
(Mus
musculus) 		5 / 10 GLU E 340
SER E 312
GLU E 283
GLU E 311
GLU E 369
 None
 1.28A 6c5uD-3tsrE:
undetectable		 6c5uD-3tsrE:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_1
(TUBULIN BETA CHAIN)		 3tsr RIBONUCLEASE
INHIBITOR
(Mus
musculus) 		5 / 12 LEU E 253
LEU E 281
SER E 173
LEU E 224
ARG E 254
 None
 1.06A 6ew0B-3tsrE:
undetectable		 6ew0B-3tsrE:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_1
(TUBULIN BETA CHAIN)		 3tsr RIBONUCLEASE
INHIBITOR
(Mus
musculus) 		5 / 12 LEU E 253
LEU E 281
SER E 173
LEU E 224
ARG E 254
 None
 1.06A 6ew0D-3tsrE:
undetectable		 6ew0D-3tsrE:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_1
(TUBULIN BETA CHAIN)		 3tsr RIBONUCLEASE
INHIBITOR
(Mus
musculus) 		5 / 12 LEU E 253
LEU E 281
SER E 173
LEU E 224
ARG E 254
 None
 1.06A 6ew0H-3tsrE:
undetectable		 6ew0H-3tsrE:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_1
(TUBULIN BETA CHAIN)		 3tsr RIBONUCLEASE
INHIBITOR
(Mus
musculus) 		5 / 12 LEU E 253
LEU E 281
SER E 173
LEU E 224
ARG E 254
 None
 1.06A 6ew0I-3tsrE:
undetectable		 6ew0I-3tsrE:
11.95