SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tsw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_1
(PROTEIN (ADENOSINE
KINASE))		 3tsw TIGHT JUNCTION
PROTEIN ZO-1
(Homo
sapiens) 		5 / 12 ASP A 517
LEU A 487
GLY A 516
GLY A 439
ALA A 483
 None
 0.97A 1bx4A-3tswA:
undetectable		 1bx4A-3tswA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_D_TC9D1206_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3tsw TIGHT JUNCTION
PROTEIN ZO-1
(Homo
sapiens) 		4 / 7 TYR A 633
TRP A 557
GLU A 530
TYR A 527
 None
 1.31A 2xytD-3tswA:
0.0		 2xytD-3tswA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_G_TC9G1206_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3tsw TIGHT JUNCTION
PROTEIN ZO-1
(Homo
sapiens) 		4 / 7 TYR A 633
TRP A 557
GLU A 530
TYR A 527
 None
 1.28A 2xytG-3tswA:
undetectable		 2xytG-3tswA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_H_TC9H1206_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3tsw TIGHT JUNCTION
PROTEIN ZO-1
(Homo
sapiens) 		4 / 7 TYR A 633
TRP A 557
GLU A 530
TYR A 527
 None
 1.25A 2xytH-3tswA:
undetectable		 2xytH-3tswA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 3tsw TIGHT JUNCTION
PROTEIN ZO-1
(Homo
sapiens) 		5 / 12 ASN A 765
PRO A 710
GLY A 651
ARG A 762
VAL A 736
 None
 1.49A 3jb2A-3tswA:
undetectable		 3jb2A-3tswA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UZZ_B_ASDB501_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 3tsw TIGHT JUNCTION
PROTEIN ZO-1
(Homo
sapiens) 		4 / 8 TYR A 669
TYR A 783
LEU A 728
TRP A 782
 None
 1.25A 3uzzB-3tswA:
undetectable		 3uzzB-3tswA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KF9_A_ACTA407_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 3tsw TIGHT JUNCTION
PROTEIN ZO-1
(Homo
sapiens) 		3 / 3 GLU A 634
ARG A 522
HIS A 524
 None
 0.86A 4kf9A-3tswA:
undetectable		 4kf9A-3tswA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_1
(ADENOSINE KINASE)		 3tsw TIGHT JUNCTION
PROTEIN ZO-1
(Homo
sapiens) 		5 / 12 ASP A 517
LEU A 487
GLY A 516
GLY A 439
ALA A 483
 None
 0.99A 4n09B-3tswA:
undetectable		 4n09B-3tswA:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_1
(ADENOSINE KINASE)		 3tsw TIGHT JUNCTION
PROTEIN ZO-1
(Homo
sapiens) 		5 / 12 ASP A 517
LEU A 487
GLY A 516
GLY A 439
ALA A 483
 None
 0.99A 4n09D-3tswA:
undetectable		 4n09D-3tswA:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWT_D_BEZD202_0
(PR 10 PROTEIN)		 3tsw TIGHT JUNCTION
PROTEIN ZO-1
(Homo
sapiens) 		3 / 3 PHE A 643
ASP A 699
LYS A 695
 None
 0.85A 6awtD-3tswA:
undetectable		 6awtD-3tswA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 3tsw TIGHT JUNCTION
PROTEIN ZO-1
(Homo
sapiens) 		5 / 9 LEU A 549
THR A 548
ASP A 547
GLY A 440
ILE A 445
 None
 1.19A 6ebpA-3tswA:
undetectable		 6ebpA-3tswA:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 3tsw TIGHT JUNCTION
PROTEIN ZO-1
(Homo
sapiens) 		5 / 10 LEU A 549
THR A 548
ASP A 547
GLY A 440
ILE A 445
 None
 1.16A 6ebpB-3tswA:
undetectable		 6ebpB-3tswA:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 3tsw TIGHT JUNCTION
PROTEIN ZO-1
(Homo
sapiens) 		5 / 10 LEU A 549
THR A 548
ASP A 547
GLY A 440
ILE A 445
 None
 1.11A 6ebpC-3tswA:
undetectable		 6ebpC-3tswA:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 3tsw TIGHT JUNCTION
PROTEIN ZO-1
(Homo
sapiens) 		5 / 10 LEU A 549
THR A 548
ASP A 547
GLY A 440
ILE A 445
 None
 1.13A 6ebpD-3tswA:
undetectable		 6ebpD-3tswA:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_A_DAHA126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)		 3tsw TIGHT JUNCTION
PROTEIN ZO-1
(Homo
sapiens) 		5 / 11 LEU A 549
THR A 548
ASP A 547
GLY A 440
ILE A 445
 None
 1.06A 6gp2A-3tswA:
undetectable		 6gp2A-3tswA:
10.74