SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tsy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		 3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE
(Arabidopsis
thaliana;
Vitis
vinifera) 		4 / 5 HIS A 890
SER A 778
LEU A 692
GLY A 803
 None
 0.94A 1a4lB-3tsyA:
undetectable		 1a4lB-3tsyA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		 3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE
(Arabidopsis
thaliana;
Vitis
vinifera) 		5 / 12 ILE A  67
PHE A  68
LEU A  80
LEU A 285
PHE A 126
 None
 0.84A 1dtlA-3tsyA:
undetectable		 1dtlA-3tsyA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE
(Arabidopsis
thaliana;
Vitis
vinifera) 		5 / 12 VAL A 969
LEU A 957
VAL A 811
ILE A 606
ILE A 609
 None
 1.02A 1epbA-3tsyA:
undetectable		 1epbA-3tsyA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE
(Arabidopsis
thaliana;
Vitis
vinifera) 		5 / 12 VAL A 969
LEU A 957
VAL A 811
ILE A 606
ILE A 609
 None
 0.89A 1epbB-3tsyA:
undetectable		 1epbB-3tsyA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_B_EAAB224_1
(GLUTATHIONE
TRANSFERASE)		 3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE
(Arabidopsis
thaliana;
Vitis
vinifera) 		5 / 12 GLY A 693
LEU A 731
LEU A 714
LEU A 701
ALA A 700
 None
 1.09A 1gseB-3tsyA:
undetectable		 1gseB-3tsyA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1430_0
(FPRA)		 3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE
(Arabidopsis
thaliana;
Vitis
vinifera) 		3 / 3 ASP A 470
ASP A 472
LYS A 400
 None
 1.16A 1lquB-3tsyA:
undetectable		 1lquB-3tsyA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHS_A_CLMA999_0
(PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE))		 3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE
(Arabidopsis
thaliana;
Vitis
vinifera) 		5 / 12 VAL A 295
ILE A 273
VAL A 258
LEU A 265
GLN A 257
 None
 0.96A 1qhsA-3tsyA:
undetectable		 1qhsA-3tsyA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U72_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE
(Arabidopsis
thaliana;
Vitis
vinifera) 		5 / 12 ALA A 322
LEU A 310
PRO A  84
ASN A  82
VAL A 272
 None
 1.32A 1u72A-3tsyA:
undetectable		 1u72A-3tsyA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_A_GBNA502_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE
(Arabidopsis
thaliana;
Vitis
vinifera) 		4 / 8 THR A 760
GLY A 755
ALA A 753
VAL A 744
 None
 0.85A 2a1hA-3tsyA:
undetectable
2a1hB-3tsyA:
undetectable		 2a1hA-3tsyA:
17.90
2a1hB-3tsyA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE
(Arabidopsis
thaliana;
Vitis
vinifera) 		3 / 3 LYS A 241
ASP A 464
ASP A 478
 None
 0.96A 2br4A-3tsyA:
2.2		 2br4A-3tsyA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE
(Arabidopsis
thaliana;
Vitis
vinifera) 		5 / 12 LEU A 250
LEU A 285
THR A 139
LEU A 118
THR A 380
 None
 1.29A 2oipB-3tsyA:
undetectable		 2oipB-3tsyA:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		 3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE
(Arabidopsis
thaliana;
Vitis
vinifera) 		4 / 7 ILE A  97
ARG A 202
PHE A 203
ILE A 188
 None
 1.10A 2q6hA-3tsyA:
undetectable		 2q6hA-3tsyA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE
(Arabidopsis
thaliana;
Vitis
vinifera) 		4 / 7 GLY A 402
CYH A 404
GLN A 375
PHE A 392
 None
 1.18A 2qx4A-3tsyA:
2.1
2qx4B-3tsyA:
4.7		 2qx4A-3tsyA:
12.70
2qx4B-3tsyA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_D_TOPD1158_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE
(Arabidopsis
thaliana;
Vitis
vinifera) 		5 / 10 ILE A 810
ALA A 697
LEU A 731
LEU A 737
ILE A 711
 None
 1.12A 2w9sD-3tsyA:
undetectable		 2w9sD-3tsyA:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_E_TOPE1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE
(Arabidopsis
thaliana;
Vitis
vinifera) 		4 / 8 ILE A 810
ALA A 697
LEU A 731
ILE A 711
 None
 0.73A 2w9sE-3tsyA:
undetectable		 2w9sE-3tsyA:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_F_TOPF1159_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE
(Arabidopsis
thaliana;
Vitis
vinifera) 		5 / 10 ILE A 810
ALA A 697
LEU A 731
LEU A 737
ILE A 711
 None
 1.09A 2w9sF-3tsyA:
undetectable		 2w9sF-3tsyA:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_1
(NON-STRUCTURAL
PROTEIN 5)		 3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE
(Arabidopsis
thaliana;
Vitis
vinifera) 		3 / 3 SER A 925
HIS A 658
ASP A 615
 None
 0.71A 2wa2B-3tsyA:
undetectable		 2wa2B-3tsyA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_1
(NON-STRUCTURAL
PROTEIN 5)		 3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE
(Arabidopsis
thaliana;
Vitis
vinifera) 		3 / 3 SER A 926
HIS A 658
ASP A 615
 None
 0.77A 2wa2B-3tsyA:
undetectable		 2wa2B-3tsyA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_1
(WNT INHIBITORY
FACTOR 1)		 3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE
(Arabidopsis
thaliana;
Vitis
vinifera) 		4 / 6 LEU A  63
ILE A  67
MET A 289
VAL A 186
 None
 1.10A 2ygoA-3tsyA:
undetectable		 2ygoA-3tsyA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3B_A_RBFA191_1
(LUMAZINE PROTEIN)		 3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE
(Arabidopsis
thaliana;
Vitis
vinifera) 		5 / 12 THR A 148
GLN A 155
ALA A 156
THR A 161
ILE A 164
 None
 1.13A 3a3bA-3tsyA:
undetectable		 3a3bA-3tsyA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE
(Arabidopsis
thaliana;
Vitis
vinifera) 		5 / 12 ILE A 966
GLY A 959
LEU A 911
VAL A 900
ILE A 896
 None
 1.29A 3adsB-3tsyA:
undetectable		 3adsB-3tsyA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6R_B_CRNB603_1
(CREATINE KINASE
B-TYPE)		 3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE
(Arabidopsis
thaliana;
Vitis
vinifera) 		4 / 6 THR A 756
VAL A 757
GLU A 779
CYH A 777
 None
 1.19A 3b6rB-3tsyA:
undetectable		 3b6rB-3tsyA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_A_SALA257_1
(TRANSCRIPTIONAL
REGULATOR)		 3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE
(Arabidopsis
thaliana;
Vitis
vinifera) 		5 / 8 CYH A 869
PHE A 958
THR A 965
ILE A 966
THR A 832
 None
 1.44A 3bpxA-3tsyA:
undetectable
3bpxB-3tsyA:
undetectable		 3bpxA-3tsyA:
9.48
3bpxB-3tsyA:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_B_SAMB300_0
(PUTATIVE RRNA
METHYLASE)		 3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE
(Arabidopsis
thaliana;
Vitis
vinifera) 		5 / 12 THR A 784
GLY A 849
ILE A 685
GLN A 682
THR A 719
 None
 1.10A 3eeyB-3tsyA:
undetectable		 3eeyB-3tsyA:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_J_SAMJ300_0
(PUTATIVE RRNA
METHYLASE)		 3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE
(Arabidopsis
thaliana;
Vitis
vinifera) 		5 / 12 THR A 784
GLY A 849
ILE A 685
LEU A 845
THR A 719
 None
 1.16A 3eeyJ-3tsyA:
undetectable		 3eeyJ-3tsyA:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHX_B_PXLB313_1
(PYRIDOXAL KINASE)		 3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE
(Arabidopsis
thaliana;
Vitis
vinifera) 		4 / 8 VAL A 929
VAL A 956
PHE A 958
HIS A 890
 None
 1.01A 3fhxB-3tsyA:
undetectable		 3fhxB-3tsyA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_2
(GLUCOCORTICOID
RECEPTOR)		 3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE
(Arabidopsis
thaliana;
Vitis
vinifera) 		3 / 3 MET A 388
CYH A 291
PRO A 384
 None
 1.15A 3h52C-3tsyA:
undetectable		 3h52C-3tsyA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP5_B_KANB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE
(Arabidopsis
thaliana;
Vitis
vinifera) 		3 / 3 ALA A 765
ARG A 772
LYS A 710
 None
 1.10A 3kp5B-3tsyA:
undetectable		 3kp5B-3tsyA:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE
(Arabidopsis
thaliana;
Vitis
vinifera) 		3 / 3 ASN A 122
ASN A  82
GLU A 125
 None
 0.73A 3kpdC-3tsyA:
undetectable		 3kpdC-3tsyA:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE
(Arabidopsis
thaliana;
Vitis
vinifera) 		3 / 3 ASN A 122
ASN A  82
GLU A 125
 None
 0.81A 3kpdB-3tsyA:
undetectable		 3kpdB-3tsyA:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDI_A_SAMA601_0
(METHYLTRANSFERASE)		 3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE
(Arabidopsis
thaliana;
Vitis
vinifera) 		5 / 12 ILE A 188
PHE A 126
ALA A 168
THR A 166
ILE A 165
 None
 1.37A 3ndiA-3tsyA:
3.7		 3ndiA-3tsyA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA193_1
(DIHYDROFOLATE
REDUCTASE)		 3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE
(Arabidopsis
thaliana;
Vitis
vinifera) 		4 / 5 ASP A 898
LEU A 897
ILE A 862
PRO A 859
 None
 1.08A 3s3vA-3tsyA:
undetectable		 3s3vA-3tsyA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE
(Arabidopsis
thaliana;
Vitis
vinifera) 		4 / 5 HIS A 972
SER A 973
THR A 947
ASP A 814
 None
 1.13A 3tm4A-3tsyA:
3.1		 3tm4A-3tsyA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE
(Arabidopsis
thaliana;
Vitis
vinifera) 		4 / 5 HIS A 972
SER A 973
THR A 947
ASP A 814
 None
 1.12A 3tm4B-3tsyA:
3.1		 3tm4B-3tsyA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		 3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE
(Arabidopsis
thaliana;
Vitis
vinifera) 		5 / 12 THR A 851
PHE A 785
GLY A 671
ALA A 800
GLY A 798
 None
 1.27A 3v3oA-3tsyA:
undetectable		 3v3oA-3tsyA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE
(Arabidopsis
thaliana;
Vitis
vinifera) 		3 / 3 GLN A 112
THR A 139
ASN A 113
 None
 0.84A 3v4tE-3tsyA:
undetectable		 3v4tE-3tsyA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE
(Arabidopsis
thaliana;
Vitis
vinifera) 		5 / 12 ILE A 299
VAL A  94
ILE A  67
LEU A  63
VAL A 228
 None
 1.01A 3w68C-3tsyA:
undetectable		 3w68C-3tsyA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE
(Arabidopsis
thaliana;
Vitis
vinifera) 		4 / 6 PHE A 852
ILE A 841
PRO A 962
PHE A 802
 None
 1.24A 4fgkA-3tsyA:
4.6		 4fgkA-3tsyA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE
(Arabidopsis
thaliana;
Vitis
vinifera) 		3 / 3 GLN A 100
THR A 210
THR A 211
 None
 0.82A 4fu9A-3tsyA:
undetectable		 4fu9A-3tsyA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUF_A_ACTA310_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE
(Arabidopsis
thaliana;
Vitis
vinifera) 		3 / 3 GLN A 100
THR A 210
THR A 211
 None
 0.81A 4fufA-3tsyA:
undetectable		 4fufA-3tsyA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE
(Arabidopsis
thaliana;
Vitis
vinifera) 		4 / 8 ASP A  45
ASN A 427
ASP A 469
ILE A 468
 None
 0.94A 4k0bA-3tsyA:
undetectable		 4k0bA-3tsyA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KKY_X_CAMX503_0
(CAMPHOR
5-MONOOXYGENASE)		 3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE
(Arabidopsis
thaliana;
Vitis
vinifera) 		4 / 6 PHE A 960
LEU A 897
VAL A 900
VAL A 956
 None
 1.17A 4kkyX-3tsyA:
undetectable		 4kkyX-3tsyA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE
(Arabidopsis
thaliana;
Vitis
vinifera) 		4 / 8 ASP A  45
ASN A 427
ASP A 469
ILE A 468
 None
 0.95A 4l7iA-3tsyA:
undetectable		 4l7iA-3tsyA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE
(Arabidopsis
thaliana;
Vitis
vinifera) 		5 / 12 VAL A 744
LEU A 746
VAL A 757
ALA A 761
LEU A 764
 None
 1.18A 4rrwA-3tsyA:
undetectable		 4rrwA-3tsyA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE
(Arabidopsis
thaliana;
Vitis
vinifera) 		5 / 12 VAL A 744
LEU A 746
VAL A 757
ALA A 761
LEU A 764
 None
 1.18A 4rrwB-3tsyA:
undetectable		 4rrwB-3tsyA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE
(Arabidopsis
thaliana;
Vitis
vinifera) 		5 / 12 VAL A 744
LEU A 746
VAL A 757
ALA A 761
LEU A 764
 None
 1.18A 4rrzA-3tsyA:
undetectable		 4rrzA-3tsyA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE
(Arabidopsis
thaliana;
Vitis
vinifera) 		5 / 12 VAL A 744
LEU A 746
VAL A 757
ALA A 761
LEU A 764
 None
 1.18A 4rrzB-3tsyA:
undetectable		 4rrzB-3tsyA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_W_BEZW801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE
(Arabidopsis
thaliana;
Vitis
vinifera) 		4 / 5 ILE A 680
GLY A 849
ILE A 670
LEU A 678
 None
 0.87A 5dzkB-3tsyA:
undetectable
5dzkI-3tsyA:
undetectable
5dzkW-3tsyA:
undetectable		 5dzkB-3tsyA:
12.95
5dzkI-3tsyA:
13.31
5dzkW-3tsyA:
1.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Y_BEZY801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE
(Arabidopsis
thaliana;
Vitis
vinifera) 		4 / 5 ILE A 680
GLY A 849
ILE A 670
LEU A 678
 None
 0.84A 5dzkd-3tsyA:
undetectable
5dzkk-3tsyA:
undetectable
5dzky-3tsyA:
undetectable		 5dzkd-3tsyA:
12.95
5dzkk-3tsyA:
13.31
5dzky-3tsyA:
1.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Z_BEZZ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE
(Arabidopsis
thaliana;
Vitis
vinifera) 		4 / 4 ILE A 680
GLY A 849
ILE A 670
LEU A 678
 None
 0.78A 5dzkl-3tsyA:
undetectable
5dzkz-3tsyA:
undetectable		 5dzkl-3tsyA:
13.31
5dzkz-3tsyA:
1.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB203_0
(HYDROXYNITRILE LYASE)		 3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE
(Arabidopsis
thaliana;
Vitis
vinifera) 		4 / 4 VAL A 811
ALA A 771
ILE A 711
THR A 712
 None
 1.06A 5e4dB-3tsyA:
undetectable		 5e4dB-3tsyA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESF_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE
(Arabidopsis
thaliana;
Vitis
vinifera) 		4 / 8 TYR A 626
TYR A 623
GLY A 787
LEU A 664
 None
 0.61A 5esfA-3tsyA:
undetectable		 5esfA-3tsyA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FEP_A_SAMA407_0
([FEFE] HYDROGENASE
MATURASE SUBUNIT
HYDE)		 3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE
(Arabidopsis
thaliana;
Vitis
vinifera) 		5 / 12 GLN A 256
SER A 253
GLY A 249
LEU A 250
ILE A 432
 None
 1.48A 5fepA-3tsyA:
undetectable		 5fepA-3tsyA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FES_A_SAMA408_0
([FEFE] HYDROGENASE
MATURASE SUBUNIT
HYDE)		 3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE
(Arabidopsis
thaliana;
Vitis
vinifera) 		5 / 12 GLN A 256
SER A 253
GLY A 249
LEU A 250
ILE A 432
 None
 1.46A 5fesA-3tsyA:
undetectable		 5fesA-3tsyA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KI6_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE
(Arabidopsis
thaliana;
Vitis
vinifera) 		4 / 5 LEU A 444
TYR A 443
LEU A 230
TYR A 232
 None
 1.41A 5ki6A-3tsyA:
undetectable		 5ki6A-3tsyA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LBT_A_6T0A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE
(Arabidopsis
thaliana;
Vitis
vinifera) 		5 / 10 PHE A 852
ILE A 841
PHE A 802
GLY A 893
GLY A 892
 None
 1.13A 5lbtA-3tsyA:
3.1
5lbtB-3tsyA:
3.9		 5lbtA-3tsyA:
12.64
5lbtB-3tsyA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_D_ADND502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE
(Arabidopsis
thaliana;
Vitis
vinifera) 		3 / 3 THR A 781
THR A 631
LEU A 796
 None
 0.61A 5m66D-3tsyA:
5.2		 5m66D-3tsyA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUE_A_VIVA302_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE
(Arabidopsis
thaliana;
Vitis
vinifera) 		5 / 12 ILE A 299
VAL A  94
ILE A  67
LEU A  63
VAL A 228
 None
 0.99A 5mueA-3tsyA:
undetectable		 5mueA-3tsyA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE
(Arabidopsis
thaliana;
Vitis
vinifera) 		5 / 12 ILE A 299
VAL A  94
ILE A  67
LEU A  63
VAL A 228
 None
 0.97A 5mugA-3tsyA:
undetectable		 5mugA-3tsyA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE
(Arabidopsis
thaliana;
Vitis
vinifera) 		4 / 5 LEU A 119
LEU A 120
GLN A 155
TYR A 232
 None
 1.34A 5uc3A-3tsyA:
undetectable		 5uc3A-3tsyA:
7.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE
(Arabidopsis
thaliana;
Vitis
vinifera) 		5 / 12 GLY A 959
LEU A 854
GLY A 893
ASN A 923
ILE A 896
 None
 1.08A 5vopB-3tsyA:
undetectable		 5vopB-3tsyA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_A_ADNA506_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)		 3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE
(Arabidopsis
thaliana;
Vitis
vinifera) 		4 / 6 TYR A 673
LEU A 793
GLU A 790
LEU A 639
 None
 1.29A 5xooA-3tsyA:
undetectable		 5xooA-3tsyA:
6.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_B_SAMB601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE
(Arabidopsis
thaliana;
Vitis
vinifera) 		4 / 7 PHE A 960
GLY A 961
GLY A 963
THR A 719
 None
 0.70A 5ybbB-3tsyA:
undetectable		 5ybbB-3tsyA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCN_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE
(Arabidopsis
thaliana;
Vitis
vinifera) 		6 / 12 LEU A 964
ILE A 966
GLY A 959
LEU A 911
ILE A 896
LEU A 971
 None
 1.36A 5ycnA-3tsyA:
undetectable		 5ycnA-3tsyA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCN_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE
(Arabidopsis
thaliana;
Vitis
vinifera) 		6 / 12 LEU A 964
ILE A 966
GLY A 959
LEU A 911
VAL A 900
ILE A 896
 None
 1.39A 5ycnA-3tsyA:
undetectable		 5ycnA-3tsyA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BER_A_DVAA2_0
(E(DVA)DP(DGL)(DHI)(D
PR)N(DAL)(DPR))		 3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE
(Arabidopsis
thaliana;
Vitis
vinifera) 		3 / 3 GLU A 766
ASP A 814
PRO A 815
 None
 0.36A 6berA-3tsyA:
undetectable		 6berA-3tsyA:
1.54