SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tt2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D0V_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3tt2 GCN5-RELATED
N-ACETYLTRANSFERASE
(Sphaerobacter
thermophilus) 		5 / 8 THR A 234
GLY A 250
GLY A 237
LEU A 236
GLY A 247
 None
 1.26A 1d0vA-3tt2A:
undetectable		 1d0vA-3tt2A:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTB_A_PZQA901_0
(GLUTATHIONE
S-TRANSFERASE)		 3tt2 GCN5-RELATED
N-ACETYLTRANSFERASE
(Sphaerobacter
thermophilus) 		3 / 3 GLN A 103
TYR A 144
ARG A 145
 None
 0.84A 1gtbA-3tt2A:
undetectable		 1gtbA-3tt2A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHA_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3tt2 GCN5-RELATED
N-ACETYLTRANSFERASE
(Sphaerobacter
thermophilus) 		5 / 8 THR A 234
GLY A 250
GLY A 237
LEU A 236
GLY A 247
 None
 1.29A 1jhaA-3tt2A:
undetectable		 1jhaA-3tt2A:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHO_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3tt2 GCN5-RELATED
N-ACETYLTRANSFERASE
(Sphaerobacter
thermophilus) 		5 / 9 THR A 234
GLY A 250
GLY A 237
LEU A 236
GLY A 247
 None
 1.27A 1jhoA-3tt2A:
undetectable		 1jhoA-3tt2A:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHR_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3tt2 GCN5-RELATED
N-ACETYLTRANSFERASE
(Sphaerobacter
thermophilus) 		5 / 9 THR A 234
GLY A 250
GLY A 237
LEU A 236
GLY A 247
 None
 1.28A 1jhrA-3tt2A:
undetectable		 1jhrA-3tt2A:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHY_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3tt2 GCN5-RELATED
N-ACETYLTRANSFERASE
(Sphaerobacter
thermophilus) 		5 / 9 THR A 234
GLY A 250
GLY A 237
LEU A 236
GLY A 247
 None
 1.28A 1jhyA-3tt2A:
undetectable		 1jhyA-3tt2A:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L4N_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3tt2 GCN5-RELATED
N-ACETYLTRANSFERASE
(Sphaerobacter
thermophilus) 		5 / 9 THR A 234
GLY A 250
GLY A 237
LEU A 236
GLY A 247
 None
 1.27A 1l4nA-3tt2A:
undetectable		 1l4nA-3tt2A:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5K_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3tt2 GCN5-RELATED
N-ACETYLTRANSFERASE
(Sphaerobacter
thermophilus) 		5 / 9 THR A 234
GLY A 250
GLY A 237
LEU A 236
GLY A 247
 None
 1.26A 1l5kA-3tt2A:
undetectable		 1l5kA-3tt2A:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5L_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3tt2 GCN5-RELATED
N-ACETYLTRANSFERASE
(Sphaerobacter
thermophilus) 		5 / 9 THR A 234
GLY A 250
GLY A 237
LEU A 236
GLY A 247
 None
 1.28A 1l5lA-3tt2A:
undetectable		 1l5lA-3tt2A:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5M_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3tt2 GCN5-RELATED
N-ACETYLTRANSFERASE
(Sphaerobacter
thermophilus) 		5 / 9 THR A 234
GLY A 250
GLY A 237
LEU A 236
GLY A 247
 None
 1.27A 1l5mA-3tt2A:
undetectable		 1l5mA-3tt2A:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_1
(DIPEPTIDYL PEPTIDASE
IV)		 3tt2 GCN5-RELATED
N-ACETYLTRANSFERASE
(Sphaerobacter
thermophilus) 		5 / 12 GLU A 239
ARG A  47
VAL A 268
TYR A 272
VAL A 271
 MES  A 343 ( 4.3A)
None
None
None
None
 1.44A 1x70B-3tt2A:
undetectable		 1x70B-3tt2A:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3tt2 GCN5-RELATED
N-ACETYLTRANSFERASE
(Sphaerobacter
thermophilus) 		4 / 7 MET A 301
ILE A 246
PRO A 162
GLY A 270
 None
 1.21A 2pnjB-3tt2A:
undetectable		 2pnjB-3tt2A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA601_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 3tt2 GCN5-RELATED
N-ACETYLTRANSFERASE
(Sphaerobacter
thermophilus) 		4 / 7 GLY A  98
ALA A  72
ALA A  70
VAL A  84
 SO4  A 338 ( 3.3A)
None
None
None
 0.77A 3a2qA-3tt2A:
undetectable		 3a2qA-3tt2A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_1
(CARBONIC ANHYDRASE)		 3tt2 GCN5-RELATED
N-ACETYLTRANSFERASE
(Sphaerobacter
thermophilus) 		5 / 10 VAL A 251
GLY A 259
ALA A 261
ALA A 263
TRP A 166
 SO4  A 331 (-4.5A)
SO4  A 331 ( 4.1A)
SO4  A 331 (-3.8A)
None
None
 1.20A 3ucjA-3tt2A:
undetectable		 3ucjA-3tt2A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_2
(CARBONIC ANHYDRASE)		 3tt2 GCN5-RELATED
N-ACETYLTRANSFERASE
(Sphaerobacter
thermophilus) 		5 / 10 VAL A 251
GLY A 259
ALA A 261
ALA A 263
TRP A 166
 SO4  A 331 (-4.5A)
SO4  A 331 ( 4.1A)
SO4  A 331 (-3.8A)
None
None
 1.18A 3ucjB-3tt2A:
undetectable		 3ucjB-3tt2A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQI_A_NIOA403_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3tt2 GCN5-RELATED
N-ACETYLTRANSFERASE
(Sphaerobacter
thermophilus) 		5 / 9 THR A 234
GLY A 250
GLY A 237
LEU A 236
GLY A 247
 None
 1.29A 4kqiA-3tt2A:
undetectable		 4kqiA-3tt2A:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_1
(NEURAMINIDASE)		 3tt2 GCN5-RELATED
N-ACETYLTRANSFERASE
(Sphaerobacter
thermophilus) 		3 / 3 ARG A 311
ASP A 319
ARG A 148
 None
 0.81A 4mx0A-3tt2A:
undetectable		 4mx0A-3tt2A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA205_0
(OXIDOREDUCTASE)		 3tt2 GCN5-RELATED
N-ACETYLTRANSFERASE
(Sphaerobacter
thermophilus) 		4 / 5 SER A 248
GLY A 247
ARG A 198
PHE A 192
 None
 1.24A 4r82A-3tt2A:
undetectable
4r82B-3tt2A:
undetectable		 4r82A-3tt2A:
21.95
4r82B-3tt2A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3tt2 GCN5-RELATED
N-ACETYLTRANSFERASE
(Sphaerobacter
thermophilus) 		4 / 7 ALA A 261
GLY A 237
THR A 210
GLU A 213
 SO4  A 331 (-3.8A)
None
None
None
 0.86A 5bs8A-3tt2A:
undetectable
5bs8C-3tt2A:
undetectable
5bs8D-3tt2A:
undetectable		 5bs8A-3tt2A:
21.29
5bs8C-3tt2A:
21.29
5bs8D-3tt2A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 3tt2 GCN5-RELATED
N-ACETYLTRANSFERASE
(Sphaerobacter
thermophilus) 		4 / 6 ALA A 261
GLY A 237
THR A 210
GLU A 213
 SO4  A 331 (-3.8A)
None
None
None
 0.88A 5btgA-3tt2A:
undetectable
5btgB-3tt2A:
undetectable
5btgC-3tt2A:
undetectable		 5btgA-3tt2A:
21.29
5btgB-3tt2A:
22.92
5btgC-3tt2A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3tt2 GCN5-RELATED
N-ACETYLTRANSFERASE
(Sphaerobacter
thermophilus) 		4 / 7 ALA A 261
GLY A 237
THR A 210
GLU A 213
 SO4  A 331 (-3.8A)
None
None
None
 0.89A 5btgA-3tt2A:
undetectable
5btgC-3tt2A:
undetectable
5btgD-3tt2A:
undetectable		 5btgA-3tt2A:
21.29
5btgC-3tt2A:
21.29
5btgD-3tt2A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1103_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 3tt2 GCN5-RELATED
N-ACETYLTRANSFERASE
(Sphaerobacter
thermophilus) 		4 / 8 PRO A 293
TYR A 296
VAL A 249
GLY A 250
 None
 0.84A 5nzyA-3tt2A:
undetectable		 5nzyA-3tt2A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA605_0
(SERUM ALBUMIN)		 3tt2 GCN5-RELATED
N-ACETYLTRANSFERASE
(Sphaerobacter
thermophilus) 		4 / 8 GLY A  86
LEU A  97
GLY A  98
LEU A 101
 MES  A 344 (-3.6A)
None
SO4  A 338 ( 3.3A)
MES  A 344 ( 4.7A)
 0.67A 6mdqA-3tt2A:
undetectable		 6mdqA-3tt2A:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 3tt2 GCN5-RELATED
N-ACETYLTRANSFERASE
(Sphaerobacter
thermophilus) 		3 / 3 ASP A 216
LEU A 219
ARG A 274
 MES  A 343 ( 3.8A)
None
None
 0.78A 7dfrA-3tt2A:
undetectable		 7dfrA-3tt2A:
19.88