SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tt9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3tt9 PLAKOPHILIN-2
(Homo
sapiens) 		4 / 4 ALA A 374
VAL A 415
ALA A 414
HIS A 379
 None
 1.20A 1q23A-3tt9A:
undetectable		 1q23A-3tt9A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3tt9 PLAKOPHILIN-2
(Homo
sapiens) 		4 / 4 ALA A 374
VAL A 415
ALA A 414
HIS A 379
 None
 1.13A 1q23K-3tt9A:
undetectable		 1q23K-3tt9A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 3tt9 PLAKOPHILIN-2
(Homo
sapiens) 		5 / 12 GLN A 378
LEU A 452
ILE A 458
VAL A 445
ALA A 414
 None
 1.07A 2g72B-3tt9A:
undetectable		 2g72B-3tt9A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_E_TOPE1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 3tt9 PLAKOPHILIN-2
(Homo
sapiens) 		4 / 8 ALA A 559
ASP A 557
PHE A 491
THR A 560
 None
 0.84A 2w9sE-3tt9A:
undetectable		 2w9sE-3tt9A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_2
(TRANSPORTER)		 3tt9 PLAKOPHILIN-2
(Homo
sapiens) 		3 / 3 SER A 466
MET A 475
ASP A 428
 None
 0.85A 4mm4B-3tt9A:
undetectable		 4mm4B-3tt9A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3tt9 PLAKOPHILIN-2
(Homo
sapiens) 		4 / 6 LEU A 398
ILE A 397
LEU A 436
GLU A 435
 None
 0.88A 4w5nA-3tt9A:
undetectable		 4w5nA-3tt9A:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 3tt9 PLAKOPHILIN-2
(Homo
sapiens) 		3 / 3 VAL A 391
GLN A 378
CYH A 381
 None
 0.71A 5icxA-3tt9A:
undetectable
5icxE-3tt9A:
undetectable		 5icxA-3tt9A:
19.76
5icxE-3tt9A:
5.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 3tt9 PLAKOPHILIN-2
(Homo
sapiens) 		3 / 3 VAL A 391
GLN A 378
CYH A 381
 None
 0.80A 5icxC-3tt9A:
undetectable
5icxF-3tt9A:
undetectable		 5icxC-3tt9A:
19.76
5icxF-3tt9A:
5.12