SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ttb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DG5_A_TOPA201_1
(DIHYDROFOLATE
REDUCTASE)		 3ttb EIGHT-HEME NITRITE
REDUCTASE
(Thioalkalivibrio
paradoxus) 		5 / 11 TRP A 444
ALA A 441
LEU A 356
PRO A 357
ILE A 449
 None
 1.20A 1dg5A-3ttbA:
undetectable		 1dg5A-3ttbA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMI_A_BHSA1610_1
(NITRIC OXIDE
SYNTHASE)		 3ttb EIGHT-HEME NITRITE
REDUCTASE
(Thioalkalivibrio
paradoxus) 		4 / 8 VAL A 129
ALA A 179
PHE A 109
GLU A 112
 HEC  A1004 (-3.9A)
HEC  A1004 ( 4.9A)
SO3  A 526 (-4.6A)
None
 1.13A 1dmiA-3ttbA:
undetectable
1dmiB-3ttbA:
undetectable		 1dmiA-3ttbA:
21.88
1dmiB-3ttbA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_D_DVAD8_0
(GRAMICIDIN A)		 3ttb EIGHT-HEME NITRITE
REDUCTASE
(Thioalkalivibrio
paradoxus) 		3 / 3 TRP A 479
VAL A 488
TRP A 482
 None
 1.49A 1gmkC-3ttbA:
undetectable
1gmkD-3ttbA:
undetectable		 1gmkC-3ttbA:
2.85
1gmkD-3ttbA:
2.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N6C_A_SAMA402_0
(SET
DOMAIN-CONTAINING
PROTEIN 7)		 3ttb EIGHT-HEME NITRITE
REDUCTASE
(Thioalkalivibrio
paradoxus) 		5 / 11 ILE A 159
ALA A 155
GLY A 154
ASN A 226
HIS A 126
 None
None
None
None
HEC  A1004 (-4.4A)
 1.25A 1n6cA-3ttbA:
undetectable		 1n6cA-3ttbA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_A_SAMA500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 3ttb EIGHT-HEME NITRITE
REDUCTASE
(Thioalkalivibrio
paradoxus) 		4 / 7 ASP A 161
PHE A 137
PHE A 172
SER A 167
 None
 1.49A 1rqpB-3ttbA:
undetectable		 1rqpB-3ttbA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_D_ADND3502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3ttb EIGHT-HEME NITRITE
REDUCTASE
(Thioalkalivibrio
paradoxus) 		5 / 12 THR A 178
ASP A 168
THR A 166
ASP A 161
GLY A 135
 None
 1.24A 1v8bD-3ttbA:
undetectable		 1v8bD-3ttbA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACK_A_EDRA999_1
(ACETYLCHOLINESTERASE)		 3ttb EIGHT-HEME NITRITE
REDUCTASE
(Thioalkalivibrio
paradoxus) 		4 / 7 GLY A 489
GLU A 485
SER A 487
HIS A 491
 None
None
None
HEC  A1007 (-3.1A)
 1.16A 2ackA-3ttbA:
2.4		 2ackA-3ttbA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_B_SAMB1299_1
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 3ttb EIGHT-HEME NITRITE
REDUCTASE
(Thioalkalivibrio
paradoxus) 		4 / 7 ASP A 161
PHE A 137
PHE A 172
SER A 167
 None
 1.47A 2v7uB-3ttbA:
undetectable		 2v7uB-3ttbA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_D_ADND438_1
(ADENOSYLHOMOCYSTEINA
SE)		 3ttb EIGHT-HEME NITRITE
REDUCTASE
(Thioalkalivibrio
paradoxus) 		5 / 12 THR A 178
ASP A 168
THR A 166
ASP A 161
GLY A 135
 None
 1.18A 3g1uD-3ttbA:
undetectable		 3g1uD-3ttbA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_A_C2FA314_0
(UNCHARACTERIZED
PROTEIN)		 3ttb EIGHT-HEME NITRITE
REDUCTASE
(Thioalkalivibrio
paradoxus) 		5 / 12 GLY A 285
LEU A 286
ILE A 193
ARG A 282
GLN A 190
 None
None
HEC  A1002 (-4.1A)
HEC  A1002 (-3.0A)
None
 1.13A 3ijdA-3ttbA:
undetectable		 3ijdA-3ttbA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_0
(UNCHARACTERIZED
PROTEIN)		 3ttb EIGHT-HEME NITRITE
REDUCTASE
(Thioalkalivibrio
paradoxus) 		5 / 12 GLY A 285
LEU A 286
ILE A 193
ARG A 282
GLN A 190
 None
None
HEC  A1002 (-4.1A)
HEC  A1002 (-3.0A)
None
 1.11A 3ijdB-3ttbA:
undetectable		 3ijdB-3ttbA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEK_A_SAMA510_0
(SET AND MYND
DOMAIN-CONTAINING
PROTEIN 3)		 3ttb EIGHT-HEME NITRITE
REDUCTASE
(Thioalkalivibrio
paradoxus) 		5 / 12 GLY A 376
ASN A 375
GLU A 373
ASN A 492
HIS A 383
 None
HEC  A1008 ( 4.0A)
None
None
HEC  A1007 ( 3.1A)
 1.36A 3mekA-3ttbA:
undetectable		 3mekA-3ttbA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_C_SAMC800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3ttb EIGHT-HEME NITRITE
REDUCTASE
(Thioalkalivibrio
paradoxus) 		5 / 11 ILE A 159
ALA A 155
GLY A 154
ASN A 226
HIS A 126
 None
None
None
None
HEC  A1004 (-4.4A)
 1.24A 4e47C-3ttbA:
undetectable		 4e47C-3ttbA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3ttb EIGHT-HEME NITRITE
REDUCTASE
(Thioalkalivibrio
paradoxus) 		5 / 12 THR A 102
LEU A 103
ALA A  91
GLU A  89
SER A  97
 None
 1.27A 4ejwA-3ttbA:
1.9		 4ejwA-3ttbA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_B_FOLB301_1
(FOLATE RECEPTOR
ALPHA)		 3ttb EIGHT-HEME NITRITE
REDUCTASE
(Thioalkalivibrio
paradoxus) 		3 / 3 ASP A 161
TRP A 208
SER A 167
 None
 1.06A 4lrhB-3ttbA:
undetectable		 4lrhB-3ttbA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA602_1
(SERUM ALBUMIN)		 3ttb EIGHT-HEME NITRITE
REDUCTASE
(Thioalkalivibrio
paradoxus) 		5 / 9 PHE A 452
ALA A 455
ALA A 458
LEU A 465
VAL A 464
 None
 1.22A 4or0A-3ttbA:
undetectable		 4or0A-3ttbA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3ttb EIGHT-HEME NITRITE
REDUCTASE
(Thioalkalivibrio
paradoxus) 		5 / 9 THR A 178
ALA A 218
GLY A 134
GLY A 135
ASP A 161
 None
 1.11A 4qwuY-3ttbA:
undetectable
4qwuZ-3ttbA:
undetectable		 4qwuY-3ttbA:
17.10
4qwuZ-3ttbA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 3ttb EIGHT-HEME NITRITE
REDUCTASE
(Thioalkalivibrio
paradoxus) 		5 / 12 LEU A 194
ILE A  21
HIS A 234
ILE A 193
ILE A 284
 HEC  A1001 ( 3.7A)
SO4  A 534 ( 3.9A)
HEC  A1002 (-3.1A)
HEC  A1002 (-4.1A)
None
 1.03A 4rp8C-3ttbA:
2.8		 4rp8C-3ttbA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		 3ttb EIGHT-HEME NITRITE
REDUCTASE
(Thioalkalivibrio
paradoxus) 		4 / 6 THR A  61
LEU A 194
ASP A 195
TYR A 228
 SO4  A 533 (-3.8A)
HEC  A1001 ( 3.7A)
None
HEC  A1002 (-3.6A)
 1.02A 4wozA-3ttbA:
undetectable
4wozB-3ttbA:
undetectable		 4wozA-3ttbA:
20.04
4wozB-3ttbA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		 3ttb EIGHT-HEME NITRITE
REDUCTASE
(Thioalkalivibrio
paradoxus) 		4 / 6 THR A  61
LEU A 221
ASP A 220
LEU A 123
 SO4  A 533 (-3.8A)
None
None
None
 0.95A 4wozA-3ttbA:
undetectable
4wozB-3ttbA:
undetectable		 4wozA-3ttbA:
20.04
4wozB-3ttbA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		 3ttb EIGHT-HEME NITRITE
REDUCTASE
(Thioalkalivibrio
paradoxus) 		4 / 5 LEU A 194
ASP A 195
TYR A 228
THR A  61
 HEC  A1001 ( 3.7A)
None
HEC  A1002 (-3.6A)
SO4  A 533 (-3.8A)
 0.97A 4wozF-3ttbA:
undetectable
4wozH-3ttbA:
undetectable		 4wozF-3ttbA:
20.04
4wozH-3ttbA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		 3ttb EIGHT-HEME NITRITE
REDUCTASE
(Thioalkalivibrio
paradoxus) 		4 / 5 LEU A 221
ASP A 220
LEU A 123
THR A  61
 None
None
None
SO4  A 533 (-3.8A)
 0.97A 4wozF-3ttbA:
undetectable
4wozH-3ttbA:
undetectable		 4wozF-3ttbA:
20.04
4wozH-3ttbA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_B_ACTB403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 3ttb EIGHT-HEME NITRITE
REDUCTASE
(Thioalkalivibrio
paradoxus) 		3 / 3 ARG A 322
ASP A 321
ARG A 323
 None
 0.51A 4wq4B-3ttbA:
undetectable		 4wq4B-3ttbA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3ttb EIGHT-HEME NITRITE
REDUCTASE
(Thioalkalivibrio
paradoxus) 		4 / 7 ARG A 117
PHE A 127
ILE A 159
TYR A 139
 None
 1.17A 5a06B-3ttbA:
undetectable		 5a06B-3ttbA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CCM_A_SAMA504_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SMYD3)		 3ttb EIGHT-HEME NITRITE
REDUCTASE
(Thioalkalivibrio
paradoxus) 		5 / 12 GLY A 376
ASN A 375
GLU A 373
ASN A 492
HIS A 383
 None
HEC  A1008 ( 4.0A)
None
None
HEC  A1007 ( 3.1A)
 1.37A 5ccmA-3ttbA:
undetectable		 5ccmA-3ttbA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_0
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 3ttb EIGHT-HEME NITRITE
REDUCTASE
(Thioalkalivibrio
paradoxus) 		5 / 12 SER A 487
PHE A 367
THR A 366
ASN A 293
VAL A 377
 None
HEC  A1007 (-4.3A)
None
HEC  A1007 ( 4.8A)
HEC  A1008 (-4.3A)
 1.41A 5d0yA-3ttbA:
undetectable		 5d0yA-3ttbA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_B_FOLB201_0
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 3ttb EIGHT-HEME NITRITE
REDUCTASE
(Thioalkalivibrio
paradoxus) 		5 / 12 SER A 487
PHE A 367
THR A 366
ASN A 293
VAL A 377
 None
HEC  A1007 (-4.3A)
None
HEC  A1007 ( 4.8A)
HEC  A1008 (-4.3A)
 1.39A 5d0yB-3ttbA:
undetectable		 5d0yB-3ttbA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA617_0
(SERUM ALBUMIN)		 3ttb EIGHT-HEME NITRITE
REDUCTASE
(Thioalkalivibrio
paradoxus) 		3 / 3 TRP A 156
ARG A 219
LEU A 185
 None
 0.97A 5dbyA-3ttbA:
undetectable		 5dbyA-3ttbA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HSW_A_ACTA501_0
(ORF 37)		 3ttb EIGHT-HEME NITRITE
REDUCTASE
(Thioalkalivibrio
paradoxus) 		4 / 5 ARG A 401
SER A 399
SER A  76
SER A  79
 None
 1.08A 5hswA-3ttbA:
undetectable		 5hswA-3ttbA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_2
(CDL2.2)		 3ttb EIGHT-HEME NITRITE
REDUCTASE
(Thioalkalivibrio
paradoxus) 		5 / 12 PRO A 258
LEU A 364
VAL A 240
LEU A 287
GLY A 285
 None
HEC  A1007 (-4.1A)
None
None
None
 1.18A 5ienA-3ttbA:
undetectable		 5ienA-3ttbA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_1
(WTFP-TAG,GP41)		 3ttb EIGHT-HEME NITRITE
REDUCTASE
(Thioalkalivibrio
paradoxus) 		5 / 12 ALA A 244
ASN A 331
GLU A 365
LEU A 364
GLU A 373
 None
None
None
HEC  A1007 (-4.1A)
None
 0.97A 5nwuA-3ttbA:
undetectable		 5nwuA-3ttbA:
5.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CLX_B_SAMB401_0
(O-METHYLTRANSFERASE)		 3ttb EIGHT-HEME NITRITE
REDUCTASE
(Thioalkalivibrio
paradoxus) 		5 / 10 ALA A 244
GLY A 200
ASP A 201
VAL A 183
ASP A 321
 None
 1.35A 6clxB-3ttbA:
undetectable		 6clxB-3ttbA:
22.20