SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ttf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_1
(TRANSTHYRETIN)		 3ttf TRANSCRIPTIONAL
REGULATORY PROTEIN
(Escherichia
coli) 		4 / 6 LEU A 484
ALA A 498
SER A 695
THR A 500
 None
 0.96A 1ictB-3ttfA:
undetectable		 1ictB-3ttfA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_D_SAMD200_0
(METHIONINE REPRESSOR)		 3ttf TRANSCRIPTIONAL
REGULATORY PROTEIN
(Escherichia
coli) 		5 / 12 HIS A 476
GLY A 505
ALA A 478
HIS A 479
LEU A 730
 None
None
None
ZN  A   3 ( 3.4A)
None
 0.95A 1mjqC-3ttfA:
undetectable
1mjqD-3ttfA:
undetectable		 1mjqC-3ttfA:
12.38
1mjqD-3ttfA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_J_SAMJ200_0
(METHIONINE REPRESSOR)		 3ttf TRANSCRIPTIONAL
REGULATORY PROTEIN
(Escherichia
coli) 		5 / 12 HIS A 476
GLY A 505
ALA A 478
HIS A 479
LEU A 730
 None
None
None
ZN  A   3 ( 3.4A)
None
 0.96A 1mjqI-3ttfA:
undetectable
1mjqJ-3ttfA:
undetectable		 1mjqI-3ttfA:
12.38
1mjqJ-3ttfA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3ttf TRANSCRIPTIONAL
REGULATORY PROTEIN
(Escherichia
coli) 		5 / 12 ALA A 602
LEU A 622
ALA A 618
VAL A 636
LEU A 655
 None
 1.01A 1xdkA-3ttfA:
undetectable		 1xdkA-3ttfA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_E_9CRE1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3ttf TRANSCRIPTIONAL
REGULATORY PROTEIN
(Escherichia
coli) 		5 / 12 ALA A 602
ALA A 600
LEU A 622
ALA A 618
VAL A 636
 None
 1.03A 1xdkE-3ttfA:
undetectable		 1xdkE-3ttfA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_E_9CRE1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3ttf TRANSCRIPTIONAL
REGULATORY PROTEIN
(Escherichia
coli) 		5 / 12 ALA A 602
LEU A 622
ALA A 618
VAL A 636
LEU A 655
 None
 1.01A 1xdkE-3ttfA:
undetectable		 1xdkE-3ttfA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_2
(POL PROTEIN)		 3ttf TRANSCRIPTIONAL
REGULATORY PROTEIN
(Escherichia
coli) 		4 / 7 ARG A 245
ALA A 217
GLY A 220
PRO A 330
 None
 0.71A 2fxdB-3ttfA:
undetectable		 2fxdB-3ttfA:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA703_0
(FERROCHELATASE)		 3ttf TRANSCRIPTIONAL
REGULATORY PROTEIN
(Escherichia
coli) 		4 / 4 LEU A 254
PRO A 255
LEU A 301
ARG A 265
 None
 1.43A 2hrcA-3ttfA:
undetectable		 2hrcA-3ttfA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 3ttf TRANSCRIPTIONAL
REGULATORY PROTEIN
(Escherichia
coli) 		3 / 3 ASP A 727
ASP A 421
ASP A 452
 AMP  A 747 ( 2.7A)
None
None
 0.68A 2igtB-3ttfA:
undetectable		 2igtB-3ttfA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_1
(ADENOSINE DEAMINASE)		 3ttf TRANSCRIPTIONAL
REGULATORY PROTEIN
(Escherichia
coli) 		5 / 12 HIS A 479
ASP A 400
HIS A 475
HIS A 476
ASP A 502
 ZN  A   3 ( 3.4A)
None
ZN  A   3 (-3.5A)
None
ZN  A   3 ( 3.3A)
 1.10A 2pgrA-3ttfA:
undetectable		 2pgrA-3ttfA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)		 3ttf TRANSCRIPTIONAL
REGULATORY PROTEIN
(Escherichia
coli) 		4 / 7 LEU A 501
GLU A 623
LEU A 703
MET A 680
 None
AMP  A 747 (-3.5A)
None
None
 1.24A 2w8yA-3ttfA:
undetectable		 2w8yA-3ttfA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_A_X2NA1480_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 3ttf TRANSCRIPTIONAL
REGULATORY PROTEIN
(Escherichia
coli) 		5 / 12 PRO A 537
ALA A 588
ALA A 602
ALA A 604
THR A 567
 None
 1.20A 2x2nA-3ttfA:
undetectable		 2x2nA-3ttfA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_B_X2NB1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 3ttf TRANSCRIPTIONAL
REGULATORY PROTEIN
(Escherichia
coli) 		5 / 12 PRO A 537
ALA A 588
ALA A 602
ALA A 604
THR A 567
 None
 1.19A 2x2nB-3ttfA:
undetectable		 2x2nB-3ttfA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA602_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 3ttf TRANSCRIPTIONAL
REGULATORY PROTEIN
(Escherichia
coli) 		4 / 7 ALA A 482
ALA A 481
ALA A 485
GLN A 734
 None
 0.89A 3a2qA-3ttfA:
undetectable		 3a2qA-3ttfA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_A_RBFA191_1
(LUMAZINE PROTEIN)		 3ttf TRANSCRIPTIONAL
REGULATORY PROTEIN
(Escherichia
coli) 		5 / 12 CYH A 228
ALA A 235
THR A 238
ASN A 214
ILE A 215
 None
 1.07A 3a35A-3ttfA:
undetectable		 3a35A-3ttfA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3ttf TRANSCRIPTIONAL
REGULATORY PROTEIN
(Escherichia
coli) 		5 / 12 ALA A 602
LEU A 622
ALA A 618
VAL A 636
LEU A 655
 None
 1.07A 3dzyA-3ttfA:
undetectable		 3dzyA-3ttfA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_F_SAMF300_0
(PUTATIVE RRNA
METHYLASE)		 3ttf TRANSCRIPTIONAL
REGULATORY PROTEIN
(Escherichia
coli) 		5 / 12 GLY A 507
ASN A 509
GLY A 503
LEU A 474
THR A 500
 None
None
AMP  A 747 ( 4.0A)
None
None
 1.06A 3eeyF-3ttfA:
undetectable		 3eeyF-3ttfA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_1
(REPRESSOR PROTEIN
MPHR(A))		 3ttf TRANSCRIPTIONAL
REGULATORY PROTEIN
(Escherichia
coli) 		4 / 5 ARG A 702
ASN A 701
HIS A 669
ALA A 626
 None
AMP  A 747 (-3.9A)
None
None
 1.28A 3frqA-3ttfA:
undetectable		 3frqA-3ttfA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_1
(REPRESSOR PROTEIN
MPHR(A))		 3ttf TRANSCRIPTIONAL
REGULATORY PROTEIN
(Escherichia
coli) 		4 / 7 ARG A 702
ASN A 701
HIS A 669
ALA A 626
 None
AMP  A 747 (-3.9A)
None
None
 1.29A 3frqB-3ttfA:
undetectable		 3frqB-3ttfA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_A_SAMA401_0
(O-METHYLTRANSFERASE)		 3ttf TRANSCRIPTIONAL
REGULATORY PROTEIN
(Escherichia
coli) 		5 / 12 TRP A 657
HIS A 669
LEU A 703
GLY A 631
ALA A 665
 None
 1.20A 3i5uA-3ttfA:
undetectable		 3i5uA-3ttfA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_B_VIBB223_1
(THIAMINE
PYROPHOSPHOKINASE)		 3ttf TRANSCRIPTIONAL
REGULATORY PROTEIN
(Escherichia
coli) 		4 / 7 LEU A 672
LEU A 501
CYH A 594
SER A 592
 None
 0.91A 3lm8B-3ttfA:
2.5
3lm8D-3ttfA:
undetectable		 3lm8B-3ttfA:
14.57
3lm8D-3ttfA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_C_VIBC223_1
(THIAMINE
PYROPHOSPHOKINASE)		 3ttf TRANSCRIPTIONAL
REGULATORY PROTEIN
(Escherichia
coli) 		4 / 8 LEU A 672
LEU A 501
CYH A 594
SER A 592
 None
 0.74A 3lm8A-3ttfA:
2.6
3lm8C-3ttfA:
2.1		 3lm8A-3ttfA:
14.57
3lm8C-3ttfA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_D_VIBD223_1
(THIAMINE
PYROPHOSPHOKINASE)		 3ttf TRANSCRIPTIONAL
REGULATORY PROTEIN
(Escherichia
coli) 		4 / 8 LEU A 672
LEU A 501
CYH A 594
SER A 592
 None
 0.93A 3lm8B-3ttfA:
2.6
3lm8D-3ttfA:
undetectable		 3lm8B-3ttfA:
14.57
3lm8D-3ttfA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIH_A_CUA357_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)		 3ttf TRANSCRIPTIONAL
REGULATORY PROTEIN
(Escherichia
coli) 		3 / 3 HIS A 479
HIS A 476
HIS A 475
 ZN  A   3 ( 3.4A)
None
ZN  A   3 (-3.5A)
 0.79A 3mihA-3ttfA:
undetectable		 3mihA-3ttfA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 3ttf TRANSCRIPTIONAL
REGULATORY PROTEIN
(Escherichia
coli) 		3 / 3 LYS A 243
ARG A 245
ASP A 424
 None
 1.34A 3o7wA-3ttfA:
undetectable		 3o7wA-3ttfA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA452_1
(CYTOCHROME P450
164A2)		 3ttf TRANSCRIPTIONAL
REGULATORY PROTEIN
(Escherichia
coli) 		5 / 12 PRO A 537
ALA A 542
VAL A 558
ASN A 549
LEU A 550
 None
 1.18A 3r9cA-3ttfA:
undetectable		 3r9cA-3ttfA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3M_A_DLUA398_1
(PFV INTEGRASE)		 3ttf TRANSCRIPTIONAL
REGULATORY PROTEIN
(Escherichia
coli) 		4 / 8 ASP A 421
ASP A 424
GLY A 327
GLN A 428
 None
 1.01A 3s3mA-3ttfA:
3.9		 3s3mA-3ttfA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3N_A_DLUA398_1
(PFV INTEGRASE)		 3ttf TRANSCRIPTIONAL
REGULATORY PROTEIN
(Escherichia
coli) 		4 / 8 ASP A 421
ASP A 424
GLY A 327
GLN A 428
 None
 0.98A 3s3nA-3ttfA:
3.8		 3s3nA-3ttfA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3ttf TRANSCRIPTIONAL
REGULATORY PROTEIN
(Escherichia
coli) 		5 / 12 ILE A 350
LYS A 219
GLY A 220
ALA A 331
ALA A 337
 None
 1.05A 3sueA-3ttfA:
undetectable		 3sueA-3ttfA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_D_SALD404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 3ttf TRANSCRIPTIONAL
REGULATORY PROTEIN
(Escherichia
coli) 		4 / 5 ASN A 549
ALA A 542
PRO A 537
ALA A 591
 None
 1.37A 3twpD-3ttfA:
undetectable		 3twpD-3ttfA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A201_2
(POL POLYPROTEIN)		 3ttf TRANSCRIPTIONAL
REGULATORY PROTEIN
(Escherichia
coli) 		5 / 9 ARG A 556
ALA A 542
ASP A 540
GLY A 503
LEU A 590
 None
None
None
AMP  A 747 ( 4.0A)
None
 1.14A 3u7sB-3ttfA:
undetectable		 3u7sB-3ttfA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3ttf TRANSCRIPTIONAL
REGULATORY PROTEIN
(Escherichia
coli) 		3 / 3 GLN A 307
THR A 108
ASN A 304
 None
 0.91A 3v4tE-3ttfA:
undetectable		 3v4tE-3ttfA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOD_A_HQEA1173_1
(FMN-BINDING PROTEIN)		 3ttf TRANSCRIPTIONAL
REGULATORY PROTEIN
(Escherichia
coli) 		4 / 7 ASP A 361
ARG A 358
HIS A 418
HIS A 225
 None
 1.34A 3zodA-3ttfA:
undetectable		 3zodA-3ttfA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD392_1
(TETX2 PROTEIN)		 3ttf TRANSCRIPTIONAL
REGULATORY PROTEIN
(Escherichia
coli) 		4 / 5 HIS A 418
SER A 374
SER A 416
VAL A 378
 None
 1.21A 4a99D-3ttfA:
undetectable		 4a99D-3ttfA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_C_UEGC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 3ttf TRANSCRIPTIONAL
REGULATORY PROTEIN
(Escherichia
coli) 		5 / 10 GLY A 595
ASP A 502
GLY A 503
VAL A 698
HIS A 476
 AMP  A 747 (-3.6A)
ZN  A   3 ( 3.3A)
AMP  A 747 ( 4.0A)
AMP  A 747 (-3.3A)
None
 1.40A 4c5lC-3ttfA:
2.4		 4c5lC-3ttfA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		 3ttf TRANSCRIPTIONAL
REGULATORY PROTEIN
(Escherichia
coli) 		4 / 7 LEU A 484
ALA A 498
SER A 695
THR A 500
 None
 0.92A 4d7bA-3ttfA:
undetectable		 4d7bA-3ttfA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3ttf TRANSCRIPTIONAL
REGULATORY PROTEIN
(Escherichia
coli) 		5 / 12 LEU A 314
LEU A 311
ILE A 207
GLN A 204
THR A 108
 None
 1.28A 4f4dA-3ttfA:
undetectable		 4f4dA-3ttfA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_B_IMNB201_1
(TRANSTHYRETIN)		 3ttf TRANSCRIPTIONAL
REGULATORY PROTEIN
(Escherichia
coli) 		4 / 6 LEU A 484
ALA A 498
SER A 695
THR A 500
 None
 0.94A 4ikiB-3ttfA:
undetectable		 4ikiB-3ttfA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_A_SUZA201_1
(TRANSTHYRETIN)		 3ttf TRANSCRIPTIONAL
REGULATORY PROTEIN
(Escherichia
coli) 		4 / 7 LEU A 484
ALA A 498
SER A 695
THR A 500
 None
 0.97A 4ikjA-3ttfA:
undetectable
4ikjB-3ttfA:
undetectable		 4ikjA-3ttfA:
10.81
4ikjB-3ttfA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_B_SUZB201_1
(TRANSTHYRETIN)		 3ttf TRANSCRIPTIONAL
REGULATORY PROTEIN
(Escherichia
coli) 		4 / 7 LEU A 484
ALA A 498
SER A 695
THR A 500
 None
 0.93A 4ikkA-3ttfA:
undetectable
4ikkB-3ttfA:
undetectable		 4ikkA-3ttfA:
10.81
4ikkB-3ttfA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_B_SHHB408_1
(HISTONE DEACETYLASE
2)		 3ttf TRANSCRIPTIONAL
REGULATORY PROTEIN
(Escherichia
coli) 		5 / 11 PRO A 724
HIS A 476
HIS A 475
ASP A 502
GLY A 696
 None
None
ZN  A   3 (-3.5A)
ZN  A   3 ( 3.3A)
AMP  A 747 ( 3.9A)
 1.37A 4lxzB-3ttfA:
undetectable		 4lxzB-3ttfA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2R_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		 3ttf TRANSCRIPTIONAL
REGULATORY PROTEIN
(Escherichia
coli) 		4 / 4 HIS A 479
GLU A 486
HIS A 487
LEU A 717
 ZN  A   3 ( 3.4A)
None
None
None
 1.23A 4m2rA-3ttfA:
undetectable		 4m2rA-3ttfA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		 3ttf TRANSCRIPTIONAL
REGULATORY PROTEIN
(Escherichia
coli) 		5 / 9 ASP A 360
ALA A 273
GLY A 222
SER A 374
GLY A 376
 None
 1.28A 4mm5A-3ttfA:
undetectable		 4mm5A-3ttfA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_A_29QA603_1
(TRANSPORTER)		 3ttf TRANSCRIPTIONAL
REGULATORY PROTEIN
(Escherichia
coli) 		5 / 9 ASP A 360
ALA A 273
GLY A 222
SER A 374
GLY A 376
 None
 1.37A 4mmeA-3ttfA:
1.0		 4mmeA-3ttfA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA205_0
(OXIDOREDUCTASE)		 3ttf TRANSCRIPTIONAL
REGULATORY PROTEIN
(Escherichia
coli) 		4 / 5 SER A 367
GLY A 368
ARG A 365
GLU A 369
 None
 1.28A 4r82A-3ttfA:
undetectable
4r82B-3ttfA:
undetectable		 4r82A-3ttfA:
16.49
4r82B-3ttfA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_0
(HYDG PROTEIN)		 3ttf TRANSCRIPTIONAL
REGULATORY PROTEIN
(Escherichia
coli) 		5 / 12 ASN A 334
LEU A 338
LEU A 349
LEU A 203
PHE A 128
 None
 1.31A 4rtbA-3ttfA:
undetectable		 4rtbA-3ttfA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 3ttf TRANSCRIPTIONAL
REGULATORY PROTEIN
(Escherichia
coli) 		4 / 5 GLY A 135
PRO A 302
THR A 108
GLN A 307
 None
 1.12A 5h5fA-3ttfA:
undetectable		 5h5fA-3ttfA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM8_B_L8PB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 3ttf TRANSCRIPTIONAL
REGULATORY PROTEIN
(Escherichia
coli) 		4 / 8 GLN A 488
GLN A 721
SER A 722
HIS A 487
 None
 1.11A 5km8A-3ttfA:
undetectable
5km8B-3ttfA:
undetectable		 5km8A-3ttfA:
12.87
5km8B-3ttfA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_A_9CRA503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3ttf TRANSCRIPTIONAL
REGULATORY PROTEIN
(Escherichia
coli) 		5 / 12 ALA A 602
ALA A 600
LEU A 622
ALA A 618
VAL A 636
 None
 0.94A 5uanA-3ttfA:
undetectable		 5uanA-3ttfA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2O_A_8N6A501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3ttf TRANSCRIPTIONAL
REGULATORY PROTEIN
(Escherichia
coli) 		5 / 12 LEU A 531
PHE A 650
MET A 638
LEU A 655
LEU A 550
 None
 1.49A 5y2oA-3ttfA:
undetectable		 5y2oA-3ttfA:
8.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA806_0
(GEPHYRIN)		 3ttf TRANSCRIPTIONAL
REGULATORY PROTEIN
(Escherichia
coli) 		4 / 4 MET A 506
GLY A 505
HIS A 476
GLY A 507
 None
 1.20A 6fgdA-3ttfA:
2.5		 6fgdA-3ttfA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_A_ACTA403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 3ttf TRANSCRIPTIONAL
REGULATORY PROTEIN
(Escherichia
coli) 		3 / 3 TYR A 146
ASP A 147
GLN A 177
 None
 0.94A 6g1pA-3ttfA:
undetectable		 6g1pA-3ttfA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		 3ttf TRANSCRIPTIONAL
REGULATORY PROTEIN
(Escherichia
coli) 		5 / 12 GLY A 728
GLY A 729
LEU A 730
GLY A 616
PRO A 720
 None
None
None
AMP  A 747 ( 4.0A)
None
 0.91A 6gngB-3ttfA:
undetectable		 6gngB-3ttfA:
22.43