SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ttg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		 3ttg PUTATIVE
AMINOMETHYLTRANSFERA
SE
(Leptospirillum
rubarum) 		4 / 5 LEU A 289
SER A 295
LEU A 298
GLY A 303
 None
 1.02A 1a4lB-3ttgA:
undetectable		 1a4lB-3ttgA:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		 3ttg PUTATIVE
AMINOMETHYLTRANSFERA
SE
(Leptospirillum
rubarum) 		4 / 5 LEU A 289
SER A 295
LEU A 298
GLY A 303
 None
 1.05A 1a4lC-3ttgA:
undetectable		 1a4lC-3ttgA:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_A_NIOA704_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3ttg PUTATIVE
AMINOMETHYLTRANSFERA
SE
(Leptospirillum
rubarum) 		4 / 4 SER A 214
PHE A 220
GLU A 215
GLY A 305
 None
 1.48A 1icvA-3ttgA:
undetectable
1icvB-3ttgA:
undetectable		 1icvA-3ttgA:
22.16
1icvB-3ttgA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_C_SAMC303_0
(HEMK PROTEIN)		 3ttg PUTATIVE
AMINOMETHYLTRANSFERA
SE
(Leptospirillum
rubarum) 		5 / 12 ILE A  41
GLY A 237
SER A 233
PHE A  59
ASN A  36
 None
 1.16A 1sg9C-3ttgA:
undetectable		 1sg9C-3ttgA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2P_B_DHIB24_0
(INSULIN B CHAIN)		 3ttg PUTATIVE
AMINOMETHYLTRANSFERA
SE
(Leptospirillum
rubarum) 		3 / 3 TYR A 149
GLY A  73
PHE A  75
 None
 0.70A 2m2pB-3ttgA:
undetectable		 2m2pB-3ttgA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_3
(PROTEASE)		 3ttg PUTATIVE
AMINOMETHYLTRANSFERA
SE
(Leptospirillum
rubarum) 		5 / 12 LEU A 263
GLY A 260
GLY A 287
ILE A 288
VAL A 326
 None
None
CL  A 336 ( 3.9A)
CL  A 336 ( 4.6A)
None
 0.94A 2nnkB-3ttgA:
undetectable		 2nnkB-3ttgA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_C_SALC1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3ttg PUTATIVE
AMINOMETHYLTRANSFERA
SE
(Leptospirillum
rubarum) 		5 / 12 THR A 292
GLY A 303
GLY A 301
PHE A  -2
ARG A 327
 None
 1.32A 2y7kC-3ttgA:
undetectable		 2y7kC-3ttgA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFE_C_TMGC1_1
(SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR SUBUNIT,
MITOCHONDRIAL
SUCCINATE
DEHYDROGENASE
CYTOCHROME B560
SUBUNIT,
MITOCHONDRIAL)		 3ttg PUTATIVE
AMINOMETHYLTRANSFERA
SE
(Leptospirillum
rubarum) 		4 / 8 ILE A 297
SER A 295
ILE A 302
ARG A 262
 None
 0.94A 3sfeB-3ttgA:
undetectable
3sfeC-3ttgA:
undetectable		 3sfeB-3ttgA:
20.48
3sfeC-3ttgA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A201_1
(POL POLYPROTEIN)		 3ttg PUTATIVE
AMINOMETHYLTRANSFERA
SE
(Leptospirillum
rubarum) 		5 / 9 LEU A 263
GLY A 260
GLY A 287
ILE A 288
VAL A 326
 None
None
CL  A 336 ( 3.9A)
CL  A 336 ( 4.6A)
None
 0.96A 3u7sA-3ttgA:
undetectable		 3u7sA-3ttgA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A83_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 3ttg PUTATIVE
AMINOMETHYLTRANSFERA
SE
(Leptospirillum
rubarum) 		5 / 12 GLY A  16
VAL A 150
ASP A 168
TYR A 200
LEU A 183
 None
 1.39A 4a83A-3ttgA:
undetectable		 4a83A-3ttgA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3ttg PUTATIVE
AMINOMETHYLTRANSFERA
SE
(Leptospirillum
rubarum) 		4 / 8 SER A 300
ARG A 262
GLU A 206
ILE A 302
 None
 0.91A 4d33A-3ttgA:
undetectable		 4d33A-3ttgA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3ttg PUTATIVE
AMINOMETHYLTRANSFERA
SE
(Leptospirillum
rubarum) 		4 / 7 SER A 300
ARG A 262
GLU A 206
ILE A 302
 None
 0.92A 4d33B-3ttgA:
undetectable		 4d33B-3ttgA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3ttg PUTATIVE
AMINOMETHYLTRANSFERA
SE
(Leptospirillum
rubarum) 		4 / 8 SER A 300
ARG A 262
GLU A 206
ILE A 302
 None
 0.91A 4d39A-3ttgA:
undetectable		 4d39A-3ttgA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3ttg PUTATIVE
AMINOMETHYLTRANSFERA
SE
(Leptospirillum
rubarum) 		4 / 7 SER A 300
ARG A 262
GLU A 206
ILE A 302
 None
 0.96A 4d39B-3ttgA:
undetectable		 4d39B-3ttgA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7G_B_ACTB902_0
(3-HYDROXYPROLINE
DEHYDRATSE)		 3ttg PUTATIVE
AMINOMETHYLTRANSFERA
SE
(Leptospirillum
rubarum) 		4 / 7 ASP A   7
ASP A 196
SER A 198
SER A 199
 None
 1.07A 4k7gB-3ttgA:
undetectable		 4k7gB-3ttgA:
25.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_E_IPHE101_0
(INSULIN)		 3ttg PUTATIVE
AMINOMETHYLTRANSFERA
SE
(Leptospirillum
rubarum) 		5 / 11 ILE A 209
LEU A 216
ALA A 225
LEU A 331
LEU A 227
 None
 0.93A 4p65E-3ttgA:
undetectable
4p65F-3ttgA:
undetectable
4p65J-3ttgA:
undetectable
4p65L-3ttgA:
undetectable		 4p65E-3ttgA:
5.90
4p65F-3ttgA:
8.20
4p65J-3ttgA:
8.20
4p65L-3ttgA:
8.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_I_IPHI101_0
(INSULIN)		 3ttg PUTATIVE
AMINOMETHYLTRANSFERA
SE
(Leptospirillum
rubarum) 		6 / 12 LEU A 331
LEU A 227
ILE A 209
LEU A 216
HIS A 159
ALA A 225
 None
 1.47A 4p65B-3ttgA:
undetectable
4p65D-3ttgA:
undetectable
4p65I-3ttgA:
undetectable
4p65J-3ttgA:
undetectable		 4p65B-3ttgA:
8.20
4p65D-3ttgA:
8.20
4p65I-3ttgA:
5.90
4p65J-3ttgA:
8.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 3ttg PUTATIVE
AMINOMETHYLTRANSFERA
SE
(Leptospirillum
rubarum) 		4 / 8 LEU A 227
LEU A 211
ILE A 288
THR A 290
 None
None
CL  A 336 ( 4.6A)
None
 0.90A 5ljbA-3ttgA:
undetectable		 5ljbA-3ttgA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0L_B_TA1B502_1
(TUBULIN BETA CHAIN)		 3ttg PUTATIVE
AMINOMETHYLTRANSFERA
SE
(Leptospirillum
rubarum) 		5 / 12 LEU A 183
LEU A 119
SER A 140
THR A 179
LEU A 144
 None
 1.06A 6b0lB-3ttgA:
undetectable		 6b0lB-3ttgA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXM_A_SAMA402_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 3ttg PUTATIVE
AMINOMETHYLTRANSFERA
SE
(Leptospirillum
rubarum) 		5 / 12 PHE A 176
LEU A 144
GLY A 147
SER A  23
ASP A 174
 None
 1.26A 6bxmA-3ttgA:
undetectable		 6bxmA-3ttgA:
21.91