SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tth'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_A_KANA558_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 3tth SPERMIDINE
N1-ACETYLTRANSFERASE
(Coxiella
burnetii) 		4 / 7 GLU A  86
GLU A  77
GLU A  57
GLU A  74
 None
 1.18A 1knyA-3tthA:
undetectable
1knyB-3tthA:
undetectable		 1knyA-3tthA:
21.26
1knyB-3tthA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3tth SPERMIDINE
N1-ACETYLTRANSFERASE
(Coxiella
burnetii) 		5 / 12 LEU A  75
TYR A 136
GLU A 103
ALA A 104
LEU A   9
 None
 1.06A 3ou6D-3tthA:
undetectable		 3ou6D-3tthA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_2
(PROTEASE)		 3tth SPERMIDINE
N1-ACETYLTRANSFERASE
(Coxiella
burnetii) 		3 / 3 ARG A 162
LEU A 124
THR A  76
 None
 0.59A 3oxcA-3tthA:
undetectable		 3oxcA-3tthA:
16.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MJ8_A_SPMA202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3tth SPERMIDINE
N1-ACETYLTRANSFERASE
(Coxiella
burnetii) 		4 / 8 GLU A  77
GLU A  86
ILE A  89
LEU A 123
 None
 0.44A 4mj8A-3tthA:
22.8		 4mj8A-3tthA:
54.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3tth SPERMIDINE
N1-ACETYLTRANSFERASE
(Coxiella
burnetii) 		4 / 5 ILE A 115
LEU A 116
GLU A 110
VAL A 165
 None
 1.05A 4nkxB-3tthA:
undetectable		 4nkxB-3tthA:
15.24