SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ttk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_B_C2FB802_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 3ttk POLYAMINE TRANSPORT
PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 SER A 180
ILE A 184
GLY A 240
SER A 242
ILE A 136
 None
 1.06A 1q8jB-3ttkA:
undetectable		 1q8jB-3ttkA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA802_1
(TRANSPORTER)		 3ttk POLYAMINE TRANSPORT
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 7 ILE A 239
ARG A 215
PHE A 211
ILE A 363
 None
 1.17A 2qb4A-3ttkA:
undetectable		 2qb4A-3ttkA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA801_1
(PROSTAGLANDIN
REDUCTASE 1)		 3ttk POLYAMINE TRANSPORT
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 8 SER A  83
TYR A 333
VAL A 309
TYR A  38
 None
 1.30A 2y05A-3ttkA:
undetectable
2y05B-3ttkA:
undetectable		 2y05A-3ttkA:
23.47
2y05B-3ttkA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_A_ADNA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 3ttk POLYAMINE TRANSPORT
PROTEIN
(Pseudomonas
aeruginosa) 		5 / 10 PHE A 292
ASP A  78
ALA A 283
VAL A  55
PHE A  47
 None
 1.39A 3ay0A-3ttkA:
undetectable		 3ay0A-3ttkA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		 3ttk POLYAMINE TRANSPORT
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 5 TYR A 241
ALA A 270
ALA A 238
TYR A 140
 None
 0.89A 3d91A-3ttkA:
undetectable		 3d91A-3ttkA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 3ttk POLYAMINE TRANSPORT
PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 PRO A 142
GLY A 174
VAL A 218
ILE A 167
ASN A 166
 None
 1.41A 3jb2A-3ttkA:
undetectable		 3jb2A-3ttkA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3ttk POLYAMINE TRANSPORT
PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 308
VAL A  81
ILE A 301
LEU A 296
VAL A 277
 None
 1.14A 3w68B-3ttkA:
undetectable		 3w68B-3ttkA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 3ttk POLYAMINE TRANSPORT
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 6 ALA A 148
ALA A 153
PRO A 154
LEU A 170
 None
 1.12A 4dtzB-3ttkA:
undetectable		 4dtzB-3ttkA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 3ttk POLYAMINE TRANSPORT
PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 TYR A  38
TYR A  57
ILE A 129
VAL A 293
ILE A 279
 None
 1.40A 4eb6B-3ttkA:
undetectable
4eb6C-3ttkA:
undetectable		 4eb6B-3ttkA:
21.27
4eb6C-3ttkA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 3ttk POLYAMINE TRANSPORT
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 7 LYS A 341
LYS A 340
TYR A 343
LEU A 118
 None
 1.20A 4yv5A-3ttkA:
undetectable		 4yv5A-3ttkA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8D_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 3ttk POLYAMINE TRANSPORT
PROTEIN
(Pseudomonas
aeruginosa) 		3 / 3 THR A 357
PRO A 181
ASP A 179
 None
 0.60A 5l8dB-3ttkA:
3.5		 5l8dB-3ttkA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWU_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 3ttk POLYAMINE TRANSPORT
PROTEIN
(Pseudomonas
aeruginosa) 		3 / 3 THR A 357
PRO A 181
ASP A 179
 None
 0.60A 5mwuB-3ttkA:
3.5		 5mwuB-3ttkA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_0
(REGULATORY PROTEIN
TETR)		 3ttk POLYAMINE TRANSPORT
PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 283
GLY A  76
SER A  75
LEU A  70
ASP A  58
 None
 1.24A 5vlmF-3ttkA:
undetectable		 5vlmF-3ttkA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3B_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 3ttk POLYAMINE TRANSPORT
PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 137
GLY A 240
ALA A 238
ILE A 265
PRO A 330
 None
 1.06A 6b3bA-3ttkA:
undetectable		 6b3bA-3ttkA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB5_A_NMYA301_0
(AAC(3)-IIIB PROTEIN)		 3ttk POLYAMINE TRANSPORT
PROTEIN
(Pseudomonas
aeruginosa) 		5 / 11 TYR A 131
ASN A 313
ASP A 307
THR A 306
THR A  43
 None
 1.14A 6mb5A-3ttkA:
undetectable		 6mb5A-3ttkA:
11.31