SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ttl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_1_T441128_1
(TRANSTHYRETIN)		 3ttl POLYAMINE TRANSPORT
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 5 LEU A 190
GLU A 161
ALA A 186
LEU A 192
 None
 1.20A 1eta1-3ttlA:
undetectable		 1eta1-3ttlA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_2_T442129_1
(TRANSTHYRETIN)		 3ttl POLYAMINE TRANSPORT
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 5 LEU A 190
GLU A 161
ALA A 186
LEU A 192
 None
 1.15A 1eta2-3ttlA:
undetectable		 1eta2-3ttlA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_B_CCSB417_0
(ESTROGEN RECEPTOR)		 3ttl POLYAMINE TRANSPORT
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 6 PRO A 278
PHE A  95
LYS A  68
VAL A  70
 None
 1.31A 1l2iB-3ttlA:
undetectable		 1l2iB-3ttlA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA140_0
(LYSOZYME C)		 3ttl POLYAMINE TRANSPORT
PROTEIN
(Pseudomonas
aeruginosa) 		3 / 3 ASN A  83
ALA A 127
ASN A 124
 None
 0.73A 1n4fA-3ttlA:
undetectable		 1n4fA-3ttlA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_2
(BETA-1 ADRENERGIC
RECEPTOR)		 3ttl POLYAMINE TRANSPORT
PROTEIN
(Pseudomonas
aeruginosa) 		3 / 3 VAL A 119
ASN A 269
TRP A 271
 None
 1.14A 2y00B-3ttlA:
undetectable		 2y00B-3ttlA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		 3ttl POLYAMINE TRANSPORT
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 5 TYR A 239
ALA A 268
ALA A 236
TYR A 139
 None
 1.06A 3d91A-3ttlA:
undetectable		 3d91A-3ttlA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3ttl POLYAMINE TRANSPORT
PROTEIN
(Pseudomonas
aeruginosa) 		5 / 10 TYR A 130
ILE A 291
VAL A 299
LYS A 302
VAL A  54
 None
 1.14A 3em0A-3ttlA:
undetectable		 3em0A-3ttlA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_B_SAMB301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 3ttl POLYAMINE TRANSPORT
PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 SER A  50
THR A  47
ILE A  78
ASP A  53
LEU A  29
 None
 1.06A 3iv6B-3ttlA:
undetectable		 3iv6B-3ttlA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_D_SAMD301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 3ttl POLYAMINE TRANSPORT
PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 SER A  50
THR A  47
ILE A  78
ASP A  53
LEU A  29
 None
 1.09A 3iv6D-3ttlA:
undetectable		 3iv6D-3ttlA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_A_OBNA1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3ttl POLYAMINE TRANSPORT
PROTEIN
(Pseudomonas
aeruginosa) 		5 / 11 PRO A 162
VAL A 235
ALA A 236
PHE A 175
ILE A 137
 None
 1.21A 3n23A-3ttlA:
undetectable		 3n23A-3ttlA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		 3ttl POLYAMINE TRANSPORT
PROTEIN
(Pseudomonas
aeruginosa) 		5 / 10 ILE A 300
ALA A 312
LEU A 295
ASN A 108
LEU A 109
 None
 1.11A 3o02A-3ttlA:
undetectable
3o02B-3ttlA:
undetectable		 3o02A-3ttlA:
22.13
3o02B-3ttlA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 3ttl POLYAMINE TRANSPORT
PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 185
GLY A 238
GLY A 136
ILE A 137
GLU A 181
 None
 0.82A 3o7wA-3ttlA:
undetectable		 3o7wA-3ttlA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_C_BEZC264_0
(CARNITINYL-COA
DEHYDRATASE)		 3ttl POLYAMINE TRANSPORT
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 6 ALA A 268
ILE A 263
LEU A 340
GLU A 181
 None
 0.89A 3r9sC-3ttlA:
undetectable		 3r9sC-3ttlA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A84_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 3ttl POLYAMINE TRANSPORT
PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 ASP A  36
VAL A 307
ILE A  38
ILE A  78
LEU A 131
 None
 1.29A 4a84A-3ttlA:
undetectable		 4a84A-3ttlA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_A_TYLA1188_1
(BROMODOMAIN
CONTAINING 2)		 3ttl POLYAMINE TRANSPORT
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 5 VAL A 128
LEU A  98
LEU A 103
ILE A  78
 None
 0.83A 4a9jA-3ttlA:
undetectable		 4a9jA-3ttlA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_B_TYLB1187_1
(BROMODOMAIN
CONTAINING 2)		 3ttl POLYAMINE TRANSPORT
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 5 VAL A 128
LEU A  98
LEU A 103
ILE A  78
 None
 0.81A 4a9jB-3ttlA:
undetectable		 4a9jB-3ttlA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_C_TYLC1184_1
(BROMODOMAIN
CONTAINING 2)		 3ttl POLYAMINE TRANSPORT
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 5 VAL A 128
LEU A  98
LEU A 103
ILE A  78
 None
 0.72A 4a9jC-3ttlA:
undetectable		 4a9jC-3ttlA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_1
(METHYLTRANSFERASE
WBDD)		 3ttl POLYAMINE TRANSPORT
PROTEIN
(Pseudomonas
aeruginosa) 		3 / 3 GLN A 116
ASP A 338
GLN A 334
 None
 0.76A 4aztA-3ttlA:
undetectable		 4aztA-3ttlA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1Y_A_RBFA1176_1
(PUTATIVE PROTEASE I)		 3ttl POLYAMINE TRANSPORT
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 8 ASN A  84
ASN A 135
THR A 134
TRP A 271
 None
 1.18A 4d1yA-3ttlA:
undetectable
4d1yB-3ttlA:
undetectable		 4d1yA-3ttlA:
20.88
4d1yB-3ttlA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3ttl POLYAMINE TRANSPORT
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 7 TRP A 132
GLY A 136
TYR A 261
GLU A 181
 None
 1.09A 4fgkB-3ttlA:
undetectable		 4fgkB-3ttlA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GRK_A_KTRA713_1
(LACTOTRANSFERRIN)		 3ttl POLYAMINE TRANSPORT
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 5 THR A  64
GLY A  67
VAL A  70
TYR A  32
 None
 1.10A 4grkA-3ttlA:
4.1		 4grkA-3ttlA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_0
(METHYLTRANSFERASE
MPPJ)		 3ttl POLYAMINE TRANSPORT
PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 233
GLY A 238
GLY A 138
ILE A 225
MET A 176
 None
 1.07A 4kicB-3ttlA:
undetectable		 4kicB-3ttlA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_A_FOLA301_1
(FOLATE RECEPTOR
ALPHA)		 3ttl POLYAMINE TRANSPORT
PROTEIN
(Pseudomonas
aeruginosa) 		3 / 3 ASP A 180
TRP A  34
SER A 343
 None
 0.94A 4lrhA-3ttlA:
undetectable		 4lrhA-3ttlA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_B_ADNB501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 3ttl POLYAMINE TRANSPORT
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 5 GLN A 354
THR A 357
LEU A 192
LEU A 187
 None
 0.90A 4lvcB-3ttlA:
undetectable		 4lvcB-3ttlA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3ttl POLYAMINE TRANSPORT
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 6 PHE A 290
MET A 275
ILE A  31
VAL A 303
 None
 1.37A 4mk4B-3ttlA:
undetectable		 4mk4B-3ttlA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_E_ADNE401_1
(CYCLIN-DEPENDENT
KINASE 9)		 3ttl POLYAMINE TRANSPORT
PROTEIN
(Pseudomonas
aeruginosa) 		5 / 7 GLY A 133
ALA A 312
ASP A 273
ASN A  83
LEU A 274
 None
 1.19A 4ogrE-3ttlA:
undetectable		 4ogrE-3ttlA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 3ttl POLYAMINE TRANSPORT
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 6 LYS A 102
LEU A 103
ASN A 105
PRO A 104
 None
 1.22A 4yv5B-3ttlA:
undetectable		 4yv5B-3ttlA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 3ttl POLYAMINE TRANSPORT
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 6 LYS A 102
LEU A 103
ASN A 105
PRO A 104
 None
 1.21A 4yv5A-3ttlA:
undetectable		 4yv5A-3ttlA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3ttl POLYAMINE TRANSPORT
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 4 GLN A 354
THR A 357
LEU A 192
LEU A 187
 None
 0.89A 5m5kB-3ttlA:
undetectable		 5m5kB-3ttlA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA303_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3ttl POLYAMINE TRANSPORT
PROTEIN
(Pseudomonas
aeruginosa) 		3 / 3 GLU A 328
TYR A 331
ARG A 317
 None
 0.79A 5uunA-3ttlA:
undetectable		 5uunA-3ttlA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3ttl POLYAMINE TRANSPORT
PROTEIN
(Pseudomonas
aeruginosa) 		3 / 3 GLU A 328
TYR A 331
ARG A 317
 None
 0.71A 5uunB-3ttlA:
undetectable		 5uunB-3ttlA:
21.99