SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tts'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1B2I_A_AMHA84_1
(PROTEIN
(PLASMINOGEN))		 3tts BETA-GALACTOSIDASE
(Bacillus
circulans) 		4 / 7 TYR A 403
ASP A 404
GLU A 406
TRP A 409
 None
 1.47A 1b2iA-3ttsA:
undetectable		 1b2iA-3ttsA:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KW0_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 3tts BETA-GALACTOSIDASE
(Bacillus
circulans) 		5 / 12 VAL A 401
LEU A 434
LEU A 610
HIS A 337
GLU A 618
 None
 1.36A 1kw0A-3ttsA:
undetectable		 1kw0A-3ttsA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_B_CCSB417_0
(ESTROGEN RECEPTOR)		 3tts BETA-GALACTOSIDASE
(Bacillus
circulans) 		4 / 6 PRO A 302
GLU A 621
LYS A 624
VAL A 623
 None
 1.40A 1l2iB-3ttsA:
undetectable		 1l2iB-3ttsA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3tts BETA-GALACTOSIDASE
(Bacillus
circulans) 		5 / 10 SER A 582
LEU A 506
VAL A 464
PHE A 468
VAL A 472
 None
 1.41A 1q23K-3ttsA:
undetectable		 1q23K-3ttsA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_A_SAMA501_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 3tts BETA-GALACTOSIDASE
(Bacillus
circulans) 		5 / 12 GLY A 562
TYR A 541
SER A 540
ALA A 563
ASP A 564
 None
 1.42A 2avdA-3ttsA:
undetectable		 2avdA-3ttsA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_A_ACTA1117_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 3tts BETA-GALACTOSIDASE
(Bacillus
circulans) 		3 / 3 ASP A 100
ARG A  98
ARG A 106
 None
 0.59A 2j9dA-3ttsA:
undetectable
2j9dC-3ttsA:
undetectable		 2j9dA-3ttsA:
11.60
2j9dC-3ttsA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_A_BEZA143_0
(PUTATIVE REDOX
PROTEIN)		 3tts BETA-GALACTOSIDASE
(Bacillus
circulans) 		4 / 7 ALA A 288
THR A 287
ALA A 290
PRO A 283
 None
 0.98A 2ql8A-3ttsA:
undetectable
2ql8B-3ttsA:
undetectable		 2ql8A-3ttsA:
11.28
2ql8B-3ttsA:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLJ_A_SPMA1303_1
(POTASSIUM CHANNEL)		 3tts BETA-GALACTOSIDASE
(Bacillus
circulans) 		3 / 3 ARG A 394
ARG A 295
PRO A 302
 None
 1.13A 2wljA-3ttsA:
undetectable		 2wljA-3ttsA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_A_J01A600_1
(ORF12)		 3tts BETA-GALACTOSIDASE
(Bacillus
circulans) 		5 / 11 SER A 114
ALA A  84
GLY A  83
SER A 148
PHE A  45
 None
 1.25A 2xf3A-3ttsA:
0.2		 2xf3A-3ttsA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_B_J01B600_1
(ORF12)		 3tts BETA-GALACTOSIDASE
(Bacillus
circulans) 		5 / 11 SER A 114
ALA A  84
GLY A  83
SER A 148
PHE A  45
 None
 1.23A 2xf3B-3ttsA:
0.9		 2xf3B-3ttsA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_A_J01A600_1
(ORF12)		 3tts BETA-GALACTOSIDASE
(Bacillus
circulans) 		5 / 10 SER A 114
ALA A  84
GLY A  83
SER A 148
PHE A  45
 None
 1.25A 2xfsA-3ttsA:
0.0		 2xfsA-3ttsA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_B_J01B600_1
(ORF12)		 3tts BETA-GALACTOSIDASE
(Bacillus
circulans) 		5 / 11 SER A 114
ALA A  84
GLY A  83
SER A 148
PHE A  45
 None
 1.23A 2xfsB-3ttsA:
0.9		 2xfsB-3ttsA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZG_B_NCAB302_0
(ADP-RIBOSYL CYCLASE
1)		 3tts BETA-GALACTOSIDASE
(Bacillus
circulans) 		4 / 7 GLU A 307
ASP A  14
SER A 273
THR A 250
 None
 1.18A 3dzgB-3ttsA:
undetectable		 3dzgB-3ttsA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_1
(REPRESSOR PROTEIN
MPHR(A))		 3tts BETA-GALACTOSIDASE
(Bacillus
circulans) 		4 / 5 ARG A 106
ASN A 113
HIS A  85
ALA A  90
 None
 1.40A 3frqA-3ttsA:
undetectable		 3frqA-3ttsA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_1
(REPRESSOR PROTEIN
MPHR(A))		 3tts BETA-GALACTOSIDASE
(Bacillus
circulans) 		4 / 7 ARG A 106
ASN A 113
HIS A  85
ALA A  90
 None
 1.40A 3frqB-3ttsA:
undetectable		 3frqB-3ttsA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_B_VORB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 3tts BETA-GALACTOSIDASE
(Bacillus
circulans) 		5 / 11 TYR A 403
VAL A 424
THR A 282
ALA A 288
THR A 287
 None
 1.13A 3mdtB-3ttsA:
undetectable		 3mdtB-3ttsA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		 3tts BETA-GALACTOSIDASE
(Bacillus
circulans) 		4 / 7 ILE A   9
GLU A 378
LEU A 653
VAL A 669
 None
 0.86A 3ua5B-3ttsA:
undetectable		 3ua5B-3ttsA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3tts BETA-GALACTOSIDASE
(Bacillus
circulans) 		4 / 8 ARG A 135
GLU A  67
ILE A  66
ASP A  64
 None
 1.06A 4d39A-3ttsA:
undetectable		 4d39A-3ttsA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3tts BETA-GALACTOSIDASE
(Bacillus
circulans) 		4 / 7 ARG A 135
GLU A  67
ILE A  66
ASP A  64
 None
 1.05A 4d39B-3ttsA:
undetectable		 4d39B-3ttsA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3tts BETA-GALACTOSIDASE
(Bacillus
circulans) 		3 / 3 ARG A 223
TRP A 182
GLY A 216
 None
 0.76A 4e7cA-3ttsA:
undetectable		 4e7cA-3ttsA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		 3tts BETA-GALACTOSIDASE
(Bacillus
circulans) 		3 / 3 PRO A 503
TYR A 584
GLY A 511
 None
 0.55A 4g2zA-3ttsA:
undetectable		 4g2zA-3ttsA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 3tts BETA-GALACTOSIDASE
(Bacillus
circulans) 		4 / 4 ILE A 490
SER A 488
ASP A 495
ASP A 220
 None
 1.39A 4krhB-3ttsA:
undetectable		 4krhB-3ttsA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3tts BETA-GALACTOSIDASE
(Bacillus
circulans) 		4 / 5 LEU A 293
ASP A 404
GLU A 448
VAL A 456
 None
 1.31A 4nkvA-3ttsA:
undetectable		 4nkvA-3ttsA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3tts BETA-GALACTOSIDASE
(Bacillus
circulans) 		3 / 3 ASP A  63
LEU A  62
PHE A  59
 None
 0.44A 4pthA-3ttsA:
undetectable		 4pthA-3ttsA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 3tts BETA-GALACTOSIDASE
(Bacillus
circulans) 		5 / 12 THR A 341
GLY A  13
GLY A  12
TRP A  10
THR A  80
 None
 1.01A 4uckB-3ttsA:
undetectable		 4uckB-3ttsA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJL_D_ERYD1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3tts BETA-GALACTOSIDASE
(Bacillus
circulans) 		5 / 12 ASN A 492
SER A 415
PHE A 487
ASP A 220
GLU A 493
 None
 1.36A 4zjlD-3ttsA:
0.0		 4zjlD-3ttsA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_D_ACTD403_0
(PROTON-GATED ION
CHANNEL)		 3tts BETA-GALACTOSIDASE
(Bacillus
circulans) 		4 / 4 ILE A 390
ARG A 650
TYR A 629
GLU A 673
 None
 1.19A 4zzbD-3ttsA:
undetectable		 4zzbD-3ttsA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_E_ACTE406_0
(PROTON-GATED ION
CHANNEL)		 3tts BETA-GALACTOSIDASE
(Bacillus
circulans) 		4 / 5 ILE A 390
ARG A 650
TYR A 629
GLU A 673
 None
 1.29A 4zzcE-3ttsA:
undetectable		 4zzcE-3ttsA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA617_0
(SERUM ALBUMIN)		 3tts BETA-GALACTOSIDASE
(Bacillus
circulans) 		3 / 3 TRP A 167
ARG A 223
LEU A 178
 None
 0.92A 5dbyA-3ttsA:
undetectable		 5dbyA-3ttsA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECM_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 3tts BETA-GALACTOSIDASE
(Bacillus
circulans) 		4 / 5 THR A 287
ALA A 290
TYR A 431
HIS A 291
 None
 1.14A 5ecmA-3ttsA:
undetectable		 5ecmA-3ttsA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_V_6V8V303_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		 3tts BETA-GALACTOSIDASE
(Bacillus
circulans) 		5 / 11 ALA A 288
ALA A 339
GLY A 338
ALA A 336
LEU A 610
 None
 1.08A 5lf7V-3ttsA:
undetectable
5lf7W-3ttsA:
undetectable		 5lf7V-3ttsA:
17.82
5lf7W-3ttsA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_D_ADND502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3tts BETA-GALACTOSIDASE
(Bacillus
circulans) 		3 / 3 THR A  41
THR A  82
LEU A 240
 None
 0.71A 5m66D-3ttsA:
2.1		 5m66D-3ttsA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 3tts BETA-GALACTOSIDASE
(Bacillus
circulans) 		3 / 3 HIS A 551
GLU A 553
TRP A 513
 None
 1.26A 5odiD-3ttsA:
undetectable		 5odiD-3ttsA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 3tts BETA-GALACTOSIDASE
(Bacillus
circulans) 		3 / 3 HIS A 551
GLU A 553
TRP A 513
 None
 1.20A 5odqD-3ttsA:
2.1		 5odqD-3ttsA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3tts BETA-GALACTOSIDASE
(Bacillus
circulans) 		3 / 3 THR A 287
MET A 289
HIS A 337
 None
 0.84A 5uunA-3ttsA:
undetectable		 5uunA-3ttsA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_2
(CYTOCHROME P450 2C9)		 3tts BETA-GALACTOSIDASE
(Bacillus
circulans) 		3 / 3 LEU A 347
VAL A  39
ASP A  38
 None
 0.62A 5x23A-3ttsA:
undetectable		 5x23A-3ttsA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA603_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 3tts BETA-GALACTOSIDASE
(Bacillus
circulans) 		3 / 3 TYR A 136
ASN A  43
LEU A  62
 None
 0.79A 6b58A-3ttsA:
undetectable		 6b58A-3ttsA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_C_LLLC301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3tts BETA-GALACTOSIDASE
(Bacillus
circulans) 		4 / 6 TYR A 277
GLU A 307
ASP A  14
CYH A  77
 None
 1.33A 6mn5C-3ttsA:
undetectable		 6mn5C-3ttsA:
8.88