SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tv2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_A_CCSA47_0
(GLUTATHIONE
S-TRANSFERASE)		 3tv2 FUMARATE HYDRATASE,
CLASS II
(Burkholderia
pseudomallei) 		4 / 7 LEU A 304
LEU A 515
GLY A 519
LEU A 428
 None
 0.83A 1gtiA-3tv2A:
undetectable		 1gtiA-3tv2A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_1
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 3tv2 FUMARATE HYDRATASE,
CLASS II
(Burkholderia
pseudomallei) 		4 / 4 ILE A 431
LEU A 428
VAL A 424
ALA A 417
 None
 0.94A 1mz9A-3tv2A:
undetectable		 1mz9A-3tv2A:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 3tv2 FUMARATE HYDRATASE,
CLASS II
(Burkholderia
pseudomallei) 		4 / 5 ILE A 431
LEU A 428
VAL A 424
ALA A 417
 None
 0.90A 1mz9C-3tv2A:
undetectable		 1mz9C-3tv2A:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 3tv2 FUMARATE HYDRATASE,
CLASS II
(Burkholderia
pseudomallei) 		4 / 8 ALA A 197
GLU A 389
ASP A 218
ILE A 221
 None
 0.85A 1p7lD-3tv2A:
undetectable		 1p7lD-3tv2A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 3tv2 FUMARATE HYDRATASE,
CLASS II
(Burkholderia
pseudomallei) 		4 / 8 ALA A 197
GLU A 389
ASP A 218
ILE A 221
 None
 0.86A 1p7lC-3tv2A:
undetectable		 1p7lC-3tv2A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 3tv2 FUMARATE HYDRATASE,
CLASS II
(Burkholderia
pseudomallei) 		4 / 8 ALA A 197
GLU A 389
ASP A 218
ILE A 221
 None
 0.86A 1rg9B-3tv2A:
undetectable		 1rg9B-3tv2A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 3tv2 FUMARATE HYDRATASE,
CLASS II
(Burkholderia
pseudomallei) 		4 / 8 ALA A 197
GLU A 389
ASP A 218
ILE A 221
 None
 0.85A 1rg9A-3tv2A:
undetectable		 1rg9A-3tv2A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 3tv2 FUMARATE HYDRATASE,
CLASS II
(Burkholderia
pseudomallei) 		4 / 8 ALA A 197
GLU A 389
ASP A 218
ILE A 221
 None
 0.85A 1rg9D-3tv2A:
undetectable		 1rg9D-3tv2A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 3tv2 FUMARATE HYDRATASE,
CLASS II
(Burkholderia
pseudomallei) 		4 / 8 ALA A 197
GLU A 389
ASP A 218
ILE A 221
 None
 0.86A 1rg9C-3tv2A:
undetectable		 1rg9C-3tv2A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RV7_B_AB1B1001_1
(PROTEASE)		 3tv2 FUMARATE HYDRATASE,
CLASS II
(Burkholderia
pseudomallei) 		5 / 11 ALA A 293
VAL A 297
LEU A 365
ALA A 401
VAL A 399
 None
 1.21A 1rv7A-3tv2A:
undetectable
1rv7B-3tv2A:
undetectable		 1rv7A-3tv2A:
12.75
1rv7B-3tv2A:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_B_D16B568_1
(THYMIDYLATE SYNTHASE)		 3tv2 FUMARATE HYDRATASE,
CLASS II
(Burkholderia
pseudomallei) 		5 / 12 HIS A 361
ASP A 484
GLY A 419
VAL A 487
ALA A 486
 None
 1.11A 2kceB-3tv2A:
undetectable		 2kceB-3tv2A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_CHDA332_0
(CHOLOYLGLYCINE
HYDROLASE)		 3tv2 FUMARATE HYDRATASE,
CLASS II
(Burkholderia
pseudomallei) 		5 / 12 ILE A 250
ALA A 196
ASN A 247
ILE A 390
ILE A 290
 None
 1.14A 2rlcA-3tv2A:
undetectable		 2rlcA-3tv2A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_CHDA332_0
(CHOLOYLGLYCINE
HYDROLASE)		 3tv2 FUMARATE HYDRATASE,
CLASS II
(Burkholderia
pseudomallei) 		5 / 12 ILE A 250
ALA A 196
ASN A 275
ILE A 390
ILE A 290
 None
 0.96A 2rlcA-3tv2A:
undetectable		 2rlcA-3tv2A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AV6_A_SAMA1_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1)		 3tv2 FUMARATE HYDRATASE,
CLASS II
(Burkholderia
pseudomallei) 		5 / 12 GLY A 343
CYH A 477
LEU A 516
ALA A 346
VAL A 345
 None
 1.04A 3av6A-3tv2A:
undetectable		 3av6A-3tv2A:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_0
(REPRESSOR PROTEIN
MPHR(A))		 3tv2 FUMARATE HYDRATASE,
CLASS II
(Burkholderia
pseudomallei) 		5 / 12 GLY A 491
VAL A 487
LEU A 421
VAL A 509
ILE A 296
 None
 0.96A 3frqB-3tv2A:
2.0		 3frqB-3tv2A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_B_CHDB1_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3tv2 FUMARATE HYDRATASE,
CLASS II
(Burkholderia
pseudomallei) 		4 / 4 LEU A 231
PRO A 230
LEU A 170
ARG A 168
 None
 1.20A 3hcoB-3tv2A:
undetectable		 3hcoB-3tv2A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_A_CL6A506_1
(CHOLESTEROL
24-HYDROXYLASE)		 3tv2 FUMARATE HYDRATASE,
CLASS II
(Burkholderia
pseudomallei) 		5 / 9 VAL A 473
LEU A 311
ILE A 431
ALA A 432
ALA A 528
 None
 1.04A 3mdvA-3tv2A:
undetectable		 3mdvA-3tv2A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_A_ADNA401_1
(PUTATIVE ADENOSINE
KINASE)		 3tv2 FUMARATE HYDRATASE,
CLASS II
(Burkholderia
pseudomallei) 		5 / 12 ILE A 191
GLY A 369
GLY A 368
THR A 286
GLY A 277
 None
 1.01A 3vaqA-3tv2A:
undetectable		 3vaqA-3tv2A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_A_ADNA401_1
(PUTATIVE ADENOSINE
KINASE)		 3tv2 FUMARATE HYDRATASE,
CLASS II
(Burkholderia
pseudomallei) 		5 / 12 ILE A 191
GLY A 369
GLY A 368
THR A 286
GLY A 277
 None
 1.00A 3vasA-3tv2A:
undetectable		 3vasA-3tv2A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DA7_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3tv2 FUMARATE HYDRATASE,
CLASS II
(Burkholderia
pseudomallei) 		5 / 10 ARG A 514
ALA A 292
VAL A 509
GLU A 183
VAL A 487
 None
 1.12A 4da7A-3tv2A:
undetectable		 4da7A-3tv2A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3tv2 FUMARATE HYDRATASE,
CLASS II
(Burkholderia
pseudomallei) 		4 / 8 ALA A 197
GLU A 389
ASP A 218
ILE A 221
 None
 0.79A 4kttB-3tv2A:
undetectable		 4kttB-3tv2A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_B_29QB603_1
(TRANSPORTER)		 3tv2 FUMARATE HYDRATASE,
CLASS II
(Burkholderia
pseudomallei) 		5 / 9 ASP A 282
VAL A 386
ALA A 384
GLY A 277
PHE A 382
 None
 1.26A 4mmeB-3tv2A:
undetectable		 4mmeB-3tv2A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_B_29QB603_1
(TRANSPORTER)		 3tv2 FUMARATE HYDRATASE,
CLASS II
(Burkholderia
pseudomallei) 		5 / 9 ASP A 282
VAL A 386
ALA A 387
GLY A 277
PHE A 382
 None
 1.34A 4mmeB-3tv2A:
undetectable		 4mmeB-3tv2A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_A_29QA603_1
(TRANSPORTER)		 3tv2 FUMARATE HYDRATASE,
CLASS II
(Burkholderia
pseudomallei) 		5 / 9 ASP A 282
VAL A 386
ALA A 387
GLY A 277
PHE A 382
 None
 1.35A 4mmfA-3tv2A:
undetectable		 4mmfA-3tv2A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_B_29QB603_1
(TRANSPORTER)		 3tv2 FUMARATE HYDRATASE,
CLASS II
(Burkholderia
pseudomallei) 		5 / 9 ASP A 282
VAL A 386
ALA A 384
GLY A 277
PHE A 382
 None
 1.27A 4mmfB-3tv2A:
0.8		 4mmfB-3tv2A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_B_29QB603_1
(TRANSPORTER)		 3tv2 FUMARATE HYDRATASE,
CLASS II
(Burkholderia
pseudomallei) 		5 / 9 ASP A 282
VAL A 386
ALA A 387
GLY A 277
PHE A 382
 None
 1.35A 4mmfB-3tv2A:
0.8		 4mmfB-3tv2A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3tv2 FUMARATE HYDRATASE,
CLASS II
(Burkholderia
pseudomallei) 		4 / 8 ALA A 197
GLU A 389
ASP A 218
ILE A 221
 None
 0.81A 4ndnB-3tv2A:
undetectable		 4ndnB-3tv2A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3tv2 FUMARATE HYDRATASE,
CLASS II
(Burkholderia
pseudomallei) 		4 / 8 ALA A 197
GLU A 389
ASP A 218
ILE A 221
 None
 0.88A 4ndnD-3tv2A:
undetectable		 4ndnD-3tv2A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJH_A_SAMA302_0
(7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE)		 3tv2 FUMARATE HYDRATASE,
CLASS II
(Burkholderia
pseudomallei) 		5 / 12 THR A 240
ASN A 245
LYS A 192
VAL A 274
ASP A 272
 None
 1.36A 4njhA-3tv2A:
undetectable		 4njhA-3tv2A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJH_B_SAMB302_0
(7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE)		 3tv2 FUMARATE HYDRATASE,
CLASS II
(Burkholderia
pseudomallei) 		5 / 12 THR A 240
ASN A 245
LYS A 192
VAL A 274
ASP A 272
 None
 1.37A 4njhB-3tv2A:
undetectable		 4njhB-3tv2A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJI_B_SAMB302_0
(7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE)		 3tv2 FUMARATE HYDRATASE,
CLASS II
(Burkholderia
pseudomallei) 		5 / 12 THR A 240
ASN A 245
LYS A 192
VAL A 274
ASP A 272
 None
 1.35A 4njiB-3tv2A:
undetectable		 4njiB-3tv2A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJK_A_SAMA302_0
(7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE)		 3tv2 FUMARATE HYDRATASE,
CLASS II
(Burkholderia
pseudomallei) 		5 / 12 THR A 240
ASN A 245
LYS A 192
VAL A 274
ASP A 272
 None
 1.37A 4njkA-3tv2A:
undetectable		 4njkA-3tv2A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJK_B_SAMB302_0
(7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE)		 3tv2 FUMARATE HYDRATASE,
CLASS II
(Burkholderia
pseudomallei) 		5 / 12 THR A 240
ASN A 245
LYS A 192
VAL A 274
ASP A 272
 None
 1.37A 4njkB-3tv2A:
undetectable		 4njkB-3tv2A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 3tv2 FUMARATE HYDRATASE,
CLASS II
(Burkholderia
pseudomallei) 		4 / 8 ALA A 197
GLU A 389
ASP A 218
ILE A 221
 None
 0.81A 5t8sA-3tv2A:
undetectable		 5t8sA-3tv2A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_A_08JA602_1
(CYTOCHROME P450 3A4)		 3tv2 FUMARATE HYDRATASE,
CLASS II
(Burkholderia
pseudomallei) 		4 / 7 ARG A 514
SER A 181
ALA A 291
ILE A 296
 None
 0.96A 5te8A-3tv2A:
0.1		 5te8A-3tv2A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_1
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 3tv2 FUMARATE HYDRATASE,
CLASS II
(Burkholderia
pseudomallei) 		4 / 6 SER A 545
GLU A 448
ASP A 434
ASP A 331
 None
 1.29A 5zw4A-3tv2A:
undetectable		 5zw4A-3tv2A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3tv2 FUMARATE HYDRATASE,
CLASS II
(Burkholderia
pseudomallei) 		4 / 7 ALA A 197
GLU A 389
ASP A 218
ILE A 221
 None
 0.85A 6fbnA-3tv2A:
undetectable		 6fbnA-3tv2A:
23.30