SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tva'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7R_A_NCTA440_1
(CYTOCHROME P450-CAM)		 3tva XYLOSE ISOMERASE
DOMAIN PROTEIN TIM
BARREL
(Planctopirus
limnophila) 		4 / 7 PHE A 107
VAL A  16
VAL A  64
ILE A  67
 None
 0.97A 1p7rA-3tvaA:
undetectable		 1p7rA-3tvaA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UYU_B_CAMB1416_0
(CYTOCHROME P450-CAM)		 3tva XYLOSE ISOMERASE
DOMAIN PROTEIN TIM
BARREL
(Planctopirus
limnophila) 		4 / 8 PHE A 107
VAL A  16
THR A  14
VAL A  64
 None
 1.16A 1uyuB-3tvaA:
undetectable		 1uyuB-3tvaA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_C_TFPC208_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3tva XYLOSE ISOMERASE
DOMAIN PROTEIN TIM
BARREL
(Planctopirus
limnophila) 		4 / 5 LEU A 154
PHE A  71
MET A 101
SER A 105
 None
 1.17A 1wrlC-3tvaA:
undetectable		 1wrlC-3tvaA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_1
(N-METHYLTRANSFERASE)		 3tva XYLOSE ISOMERASE
DOMAIN PROTEIN TIM
BARREL
(Planctopirus
limnophila) 		3 / 3 TYR A  76
TYR A 188
GLU A 256
 GOL  A 292 (-3.9A)
None
MG  A 291 ( 2.8A)
 0.93A 3pfgA-3tvaA:
undetectable		 3pfgA-3tvaA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_1
(N-METHYLTRANSFERASE)		 3tva XYLOSE ISOMERASE
DOMAIN PROTEIN TIM
BARREL
(Planctopirus
limnophila) 		3 / 3 TYR A  76
TYR A 188
GLU A 258
 GOL  A 292 (-3.9A)
None
GOL  A 292 (-3.1A)
 0.99A 3pfgA-3tvaA:
undetectable		 3pfgA-3tvaA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAJ_B_ACAB512_1
(HIV-1 YU2 GP120
ENVELOPE
GLYCOPROTEIN)		 3tva XYLOSE ISOMERASE
DOMAIN PROTEIN TIM
BARREL
(Planctopirus
limnophila) 		4 / 6 GLY A  70
PRO A  42
HIS A  43
ARG A  45
 None
 1.18A 4lajA-3tvaA:
undetectable
4lajB-3tvaA:
undetectable		 4lajA-3tvaA:
21.34
4lajB-3tvaA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CXV_A_0HKA501_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M1,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M1)		 3tva XYLOSE ISOMERASE
DOMAIN PROTEIN TIM
BARREL
(Planctopirus
limnophila) 		3 / 3 THR A  82
THR A  85
PHE A  71
 None
 0.80A 5cxvA-3tvaA:
undetectable		 5cxvA-3tvaA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_A_SAMA801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 3tva XYLOSE ISOMERASE
DOMAIN PROTEIN TIM
BARREL
(Planctopirus
limnophila) 		5 / 12 GLY A 191
THR A 190
ALA A 196
LEU A 197
VAL A 200
 None
 1.23A 5hw4A-3tvaA:
undetectable		 5hw4A-3tvaA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_C_SAMC801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 3tva XYLOSE ISOMERASE
DOMAIN PROTEIN TIM
BARREL
(Planctopirus
limnophila) 		5 / 12 GLY A 191
THR A 190
ALA A 196
LEU A 197
VAL A 200
 None
 1.24A 5hw4C-3tvaA:
undetectable		 5hw4C-3tvaA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_A_BEZA301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 3tva XYLOSE ISOMERASE
DOMAIN PROTEIN TIM
BARREL
(Planctopirus
limnophila) 		5 / 10 GLY A 117
GLY A  69
LEU A 118
LEU A  88
GLU A  74
 None
 1.39A 5hwkA-3tvaA:
undetectable		 5hwkA-3tvaA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_B_BEZB301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 3tva XYLOSE ISOMERASE
DOMAIN PROTEIN TIM
BARREL
(Planctopirus
limnophila) 		5 / 10 GLY A 117
GLY A  69
LEU A 118
LEU A  88
GLU A  74
 None
 1.38A 5hwkB-3tvaA:
undetectable		 5hwkB-3tvaA:
22.76