SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tvk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA699_1
(ADENOSINE KINASE)		 3tvk DIGUANYLATE CYCLASE
DGCZ
(Escherichia
coli) 		5 / 12 ASP A 182
LEU A 137
GLY A 181
ASN A 173
THR A 135
 C2E  A 501 (-3.6A)
None
C2E  A 501 (-3.4A)
C2E  A 501 (-3.1A)
None
 1.15A 1likA-3tvkA:
undetectable		 1likA-3tvkA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 3tvk DIGUANYLATE CYCLASE
DGCZ
(Escherichia
coli) 		5 / 12 THR A 196
VAL A 202
PHE A 210
THR A 250
VAL A 233
 None
 1.27A 2x2iA-3tvkA:
undetectable		 2x2iA-3tvkA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA819_0
(GEPHYRIN)		 3tvk DIGUANYLATE CYCLASE
DGCZ
(Escherichia
coli) 		3 / 3 ARG A 204
GLY A 207
GLU A 208
 C2E  A 501 (-3.7A)
C2E  A 501 (-3.4A)
C2E  A 501 (-4.0A)
 0.48A 6fgdA-3tvkA:
undetectable		 6fgdA-3tvkA:
18.14