SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tvl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KIJ_B_NOVB444_2 (DNA GYRASE SUBUNIT B)	3tvl	THIAMINE-TRIPHOSPHAT ASE (Homo sapiens)	3 / 3	ASP A 147 PHE A 12 VAL A 144	None	0.78A	1kijB-3tvlA: undetectable	1kijB-3tvlA: 20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3MBG_C_ACTC800_0 (FAD-LINKED SULFHYDRYL OXIDASE ALR)	3tvl	THIAMINE-TRIPHOSPHAT ASE (Homo sapiens)	3 / 3	ASP A 145 ARG A 143 ALA A 127	3PO A 231 ( 4.9A) None None	0.71A	3mbgC-3tvlA: undetectable	3mbgC-3tvlA: 19.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3TJ7_C_ACTC608_0 (GBAA_1210 PROTEIN)	3tvl	THIAMINE-TRIPHOSPHAT ASE (Homo sapiens)	4 / 5	GLU A 159 ARG A 57 LYS A 65 ARG A 125	3PO A 231 ( 4.3A) 3PO A 231 (-3.0A) 3PO A 231 (-2.7A) 3PO A 231 (-2.9A)	1.08A	3tj7C-3tvlA: 12.6	3tj7C-3tvlA: 30.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4CPZ_G_ZMRG1471_1 (NEURAMINIDASE)	3tvl	THIAMINE-TRIPHOSPHAT ASE (Homo sapiens)	5 / 12	ARG A 57 ALA A 192 GLU A 9 GLU A 7 ARG A 125	3PO A 231 (-3.0A) 3PO A 231 ( 4.2A) None 3PO A 231 ( 4.4A) 3PO A 231 (-2.9A)	1.36A	4cpzG-3tvlA: undetectable	4cpzG-3tvlA: 20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5LF3_H_BO2H306_1 (PROTEASOME SUBUNIT BETA TYPE-7 PROTEASOME SUBUNIT BETA TYPE-3)	3tvl	THIAMINE-TRIPHOSPHAT ASE (Homo sapiens)	5 / 10	THR A 87 GLU A 85 CYH A 93 ALA A 103 ASP A 105	None	1.12A	5lf3H-3tvlA: undetectable 5lf3I-3tvlA: undetectable	5lf3H-3tvlA: 22.30 5lf3I-3tvlA: 18.64

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1KIJ_B_NOVB444_2","DNA GYRASE SUBUNIT B","3tvl","THIAMINE-TRIPHOSPHATASE","Homo sapiens",3,"ASP A 147;PHE A  12;VAL A 144","None","0.78A","1kijB-3tvlA:undetectable","1kijB-3tvlA:20.45"],["3MBG_C_ACTC800_0","FAD-LINKED SULFHYDRYL OXIDASE ALR","3tvl","THIAMINE-TRIPHOSPHATASE","Homo sapiens",3,"ASP A 145;ARG A 143;ALA A 127","3PO A 231 ( 4.9A);None;None","0.71A","3mbgC-3tvlA:undetectable","3mbgC-3tvlA:19.23"],["3TJ7_C_ACTC608_0","GBAA_1210 PROTEIN","3tvl","THIAMINE-TRIPHOSPHATASE","Homo sapiens",4,"GLU A 159;ARG A  57;LYS A  65;ARG A 125","3PO A 231 ( 4.3A);3PO A 231 (-3.0A);3PO A 231 (-2.7A);3PO A 231 (-2.9A)","1.08A","3tj7C-3tvlA:12.6","3tj7C-3tvlA:30.04"],["4CPZ_G_ZMRG1471_1","NEURAMINIDASE","3tvl","THIAMINE-TRIPHOSPHATASE","Homo sapiens",5,"ARG A  57;ALA A 192;GLU A   9;GLU A   7;ARG A 125","3PO A 231 (-3.0A);3PO A 231 ( 4.2A);None;3PO A 231 ( 4.4A);3PO A 231 (-2.9A)","1.36A","4cpzG-3tvlA:undetectable","4cpzG-3tvlA:20.22"],["5LF3_H_BO2H306_1","PROTEASOME SUBUNIT BETA TYPE-7;PROTEASOME SUBUNIT BETA TYPE-3","3tvl","THIAMINE-TRIPHOSPHATASE","Homo sapiens",5,"THR A  87;GLU A  85;CYH A  93;ALA A 103;ASP A 105","None","1.12A","5lf3H-3tvlA:undetectable;5lf3I-3tvlA:undetectable","5lf3H-3tvlA:22.30;5lf3I-3tvlA:18.64"]]