SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tw0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1B2I_A_AMHA84_1
(PROTEIN
(PLASMINOGEN))		 3tw0 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
agalactiae) 		4 / 7 TYR A 490
ASP A 438
GLU A 440
TRP A 487
 None
 1.18A 1b2iA-3tw0A:
undetectable		 1b2iA-3tw0A:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHS_A_CLMA999_0
(PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE))		 3tw0 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
agalactiae) 		5 / 12 ILE A 509
ILE A 393
PHE A 395
ILE A 420
LEU A 411
 None
 1.04A 1qhsA-3tw0A:
undetectable		 1qhsA-3tw0A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA999_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 3tw0 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
agalactiae) 		5 / 12 ILE A 509
ILE A 393
PHE A 395
ILE A 420
LEU A 411
 None
 1.05A 1qhyA-3tw0A:
undetectable		 1qhyA-3tw0A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_B_BEZB1503_0
(RAS-RELATED PROTEIN
RAB-9A)		 3tw0 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
agalactiae) 		4 / 6 VAL A 267
THR A 322
GLU A 327
LEU A 331
 None
 1.07A 1s8fB-3tw0A:
2.8		 1s8fB-3tw0A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3tw0 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
agalactiae) 		5 / 12 TYR A 529
ALA A 363
ILE A 366
ILE A 379
ILE A 259
 None
 1.04A 1xozA-3tw0A:
undetectable		 1xozA-3tw0A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZQ_A_PCFA954_0
(CATECHOL
1,2-DIOXYGENASE)		 3tw0 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
agalactiae) 		5 / 9 THR A 383
ALA A 359
LEU A 360
GLU A 365
LEU A 319
 None
 0.99A 2azqA-3tw0A:
undetectable		 2azqA-3tw0A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 3tw0 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
agalactiae) 		5 / 12 HIS A 381
ALA A 353
SER A 231
GLY A 439
TYR A 519
 None
ACT  A 702 (-4.4A)
MG  A 701 ( 1.9A)
ACT  A 702 (-4.1A)
None
 1.13A 2igtC-3tw0A:
2.4		 2igtC-3tw0A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 3tw0 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
agalactiae) 		5 / 12 ALA A 251
GLY A 537
GLY A 535
ASP A 541
ARG A 238
 None
 0.84A 3o7wA-3tw0A:
undetectable		 3o7wA-3tw0A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_1
(ENDOTHIAPEPSIN)		 3tw0 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
agalactiae) 		5 / 10 ALA A 353
ILE A 427
TYR A 391
THR A 388
ILE A 509
 ACT  A 702 (-4.4A)
None
None
ACT  A 702 (-2.9A)
None
 1.22A 3prsA-3tw0A:
undetectable		 3prsA-3tw0A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC610_0
(GBAA_1210 PROTEIN)		 3tw0 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
agalactiae) 		3 / 3 ASN A 539
ALA A 239
ARG A 244
 None
 0.79A 3tj7C-3tw0A:
undetectable
3tj7D-3tw0A:
undetectable		 3tj7C-3tw0A:
19.50
3tj7D-3tw0A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3tw0 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
agalactiae) 		4 / 5 TYR A 490
SER A 285
GLY A 287
ARG A 488
 None
 1.42A 3v4tA-3tw0A:
0.7
3v4tD-3tw0A:
undetectable		 3v4tA-3tw0A:
23.95
3v4tD-3tw0A:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJR_A_0LAA404_1
(DNA POLYMERASE III
SUBUNIT BETA)		 3tw0 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
agalactiae) 		5 / 9 THR A 271
LEU A 269
PRO A 336
VAL A 252
VAL A 226
 None
 1.15A 4mjrA-3tw0A:
undetectable		 4mjrA-3tw0A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVX_B_GMRB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 3tw0 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
agalactiae) 		5 / 12 LEU A 227
TYR A 272
HIS A 381
LEU A 378
PHE A 520
 None
 1.38A 4yvxB-3tw0A:
undetectable		 4yvxB-3tw0A:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_B_FK5B201_1
(FK506-BINDING
PROTEIN 1)		 3tw0 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
agalactiae) 		5 / 11 PHE A 355
VAL A 435
TYR A 494
ILE A 393
ILE A 509
 None
 1.33A 5hw8B-3tw0A:
undetectable		 5hw8B-3tw0A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA613_1
(SERUM ALBUMIN)		 3tw0 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
agalactiae) 		4 / 8 ARG A 238
ALA A 339
THR A 383
GLY A 352
 None
 0.88A 5v0vA-3tw0A:
undetectable		 5v0vA-3tw0A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB9_D_NMYD302_0
(AAC(3)-IIIB PROTEIN)		 3tw0 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
agalactiae) 		5 / 10 TYR A 563
ASP A 229
THR A 383
GLY A 540
ASP A 541
 None
MG  A 701 ( 4.0A)
None
None
None
 1.49A 6mb9D-3tw0A:
undetectable		 6mb9D-3tw0A:
13.22