SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tw8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_2
(PROTEIN (ADENOSINE
KINASE))		 3tw8 DENN
DOMAIN-CONTAINING
PROTEIN 1B
(Homo
sapiens) 		3 / 3 LEU A 203
SER A 201
ASN A  64
 None
 0.82A 1bx4A-3tw8A:
undetectable		 1bx4A-3tw8A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_A_FLPA1650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 3tw8 DENN
DOMAIN-CONTAINING
PROTEIN 1B
(Homo
sapiens) 		5 / 12 LEU A 186
ILE A 210
GLY A 212
ALA A 214
LEU A 217
 None
 1.07A 1cqeA-3tw8A:
undetectable		 1cqeA-3tw8A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_B_FLPB2650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 3tw8 DENN
DOMAIN-CONTAINING
PROTEIN 1B
(Homo
sapiens) 		5 / 12 LEU A 186
ILE A 210
GLY A 212
ALA A 214
LEU A 217
 None
 1.06A 1cqeB-3tw8A:
undetectable		 1cqeB-3tw8A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3002_1
(SERUM ALBUMIN)		 3tw8 DENN
DOMAIN-CONTAINING
PROTEIN 1B
(Homo
sapiens) 		4 / 8 GLN A 315
LEU A 171
TYR A 174
LEU A 296
 None
 0.92A 1hk2A-3tw8A:
2.6		 1hk2A-3tw8A:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3002_1
(SERUM ALBUMIN)		 3tw8 DENN
DOMAIN-CONTAINING
PROTEIN 1B
(Homo
sapiens) 		4 / 8 GLN A 315
LEU A 171
TYR A 174
LEU A 296
 None
 0.96A 1hk3A-3tw8A:
2.5		 1hk3A-3tw8A:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 3tw8 RAS-RELATED PROTEIN
RAB-35
(Homo
sapiens) 		4 / 8 LYS B 173
THR B 165
PHE B   9
ASP B   6
 None
 1.20A 1p7lC-3tw8B:
undetectable		 1p7lC-3tw8B:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VM1_A_TAZA504_1
(BETA-LACTAMASE SHV-1)		 3tw8 DENN
DOMAIN-CONTAINING
PROTEIN 1B
RAS-RELATED PROTEIN
RAB-35
(Homo
sapiens) 		3 / 3 ASP B  44
TYR B  37
GLU A  44
 None
 0.85A 1vm1A-3tw8B:
undetectable		 1vm1A-3tw8B:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3tw8 DENN
DOMAIN-CONTAINING
PROTEIN 1B
(Homo
sapiens) 		4 / 5 PHE A 319
LEU A 284
PHE A 341
SER A 346
 None
 1.35A 1wrkB-3tw8A:
undetectable		 1wrkB-3tw8A:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_B_FLPB2701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3tw8 DENN
DOMAIN-CONTAINING
PROTEIN 1B
(Homo
sapiens) 		5 / 12 LEU A 186
ILE A 210
GLY A 212
ALA A 214
LEU A 217
 None
 1.04A 2aylB-3tw8A:
undetectable		 2aylB-3tw8A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_A_H4BA1290_1
(PTERIDINE REDUCTASE
1)		 3tw8 DENN
DOMAIN-CONTAINING
PROTEIN 1B
(Homo
sapiens) 		4 / 8 SER A 321
PHE A 319
LEU A 359
LEU A 284
 None
 0.86A 2bfpA-3tw8A:
undetectable		 2bfpA-3tw8A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_B_H4BB1290_1
(PTERIDINE REDUCTASE
1)		 3tw8 DENN
DOMAIN-CONTAINING
PROTEIN 1B
(Homo
sapiens) 		4 / 8 SER A 321
PHE A 319
LEU A 359
LEU A 284
 None
 0.83A 2bfpB-3tw8A:
undetectable		 2bfpB-3tw8A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_ACTA148_0
(UPF0066 PROTEIN
AF_0241)		 3tw8 DENN
DOMAIN-CONTAINING
PROTEIN 1B
(Homo
sapiens) 		3 / 3 VAL A 342
GLU A 338
GLU A 339
 None
 0.73A 2nv4A-3tw8A:
undetectable		 2nv4A-3tw8A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_0
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 3tw8 RAS-RELATED PROTEIN
RAB-35
(Homo
sapiens) 		5 / 12 ILE B 144
TYR B  88
VAL B  90
LEU B 117
LEU B  24
 None
 0.96A 2rctA-3tw8B:
undetectable		 2rctA-3tw8B:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_C_ASDC1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 3tw8 DENN
DOMAIN-CONTAINING
PROTEIN 1B
(Homo
sapiens) 		4 / 8 ILE A 227
GLY A 247
LEU A 206
LEU A 203
 None
 0.88A 2vctC-3tw8A:
undetectable		 2vctC-3tw8A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_C_ASDC1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 3tw8 DENN
DOMAIN-CONTAINING
PROTEIN 1B
(Homo
sapiens) 		5 / 8 ILE A 246
GLY A 247
LEU A 206
LEU A 203
PHE A  52
 None
 1.44A 2vctC-3tw8A:
undetectable		 2vctC-3tw8A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YDO_A_ADNA400_1
(ADENOSINE RECEPTOR
A2A)		 3tw8 DENN
DOMAIN-CONTAINING
PROTEIN 1B
(Homo
sapiens) 		5 / 12 LEU A 296
THR A 301
PHE A 311
MET A 183
LEU A 171
 None
 1.30A 2ydoA-3tw8A:
undetectable		 2ydoA-3tw8A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_B_BEZB261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 3tw8 RAS-RELATED PROTEIN
RAB-35
(Homo
sapiens) 		4 / 8 ILE B  14
TRP B 102
PHE B  70
TYR B  77
 None
 1.30A 3ccfB-3tw8B:
3.5		 3ccfB-3tw8B:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX95_0
(PROTEIN S100-B)		 3tw8 DENN
DOMAIN-CONTAINING
PROTEIN 1B
(Homo
sapiens) 		3 / 3 CYH A  53
PHE A  52
PHE A  72
 None
 0.88A 3cr5X-3tw8A:
undetectable		 3cr5X-3tw8A:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 3tw8 RAS-RELATED PROTEIN
RAB-35
(Homo
sapiens) 		3 / 3 ARG B 127
ASP B  89
ASP B 124
 None
 0.78A 3jb2A-3tw8B:
undetectable		 3jb2A-3tw8B:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 3tw8 RAS-RELATED PROTEIN
RAB-35
(Homo
sapiens) 		3 / 3 ARG B 127
ASP B  89
ASP B 124
 None
 0.85A 3jb3A-3tw8B:
2.3		 3jb3A-3tw8B:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3tw8 DENN
DOMAIN-CONTAINING
PROTEIN 1B
(Homo
sapiens) 		5 / 12 LEU A 186
ILE A 210
GLY A 212
ALA A 214
LEU A 217
 None
 1.09A 3n8xA-3tw8A:
undetectable		 3n8xA-3tw8A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3tw8 DENN
DOMAIN-CONTAINING
PROTEIN 1B
(Homo
sapiens) 		5 / 12 LEU A 186
ILE A 210
GLY A 212
ALA A 214
LEU A 217
 None
 1.11A 3n8xB-3tw8A:
undetectable		 3n8xB-3tw8A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_B_FLPB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3tw8 DENN
DOMAIN-CONTAINING
PROTEIN 1B
(Homo
sapiens) 		5 / 12 LEU A 186
ILE A 210
GLY A 212
ALA A 214
LEU A 217
 None
 1.02A 3n8zB-3tw8A:
undetectable		 3n8zB-3tw8A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU5_B_478B401_1
(PROTEASE)		 3tw8 DENN
DOMAIN-CONTAINING
PROTEIN 1B
RAS-RELATED PROTEIN
RAB-35
(Homo
sapiens) 		6 / 12 GLY B  66
ALA B  65
ASP A  76
GLY B  18
VAL B  19
ILE B  38
 None
 1.32A 3nu5A-3tw8B:
undetectable		 3nu5A-3tw8B:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3tw8 DENN
DOMAIN-CONTAINING
PROTEIN 1B
(Homo
sapiens) 		3 / 3 TYR A 218
ASP A   3
ASP A 367
 None
 0.93A 3ou6B-3tw8A:
undetectable		 3ou6B-3tw8A:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_B_478B200_2
(HIV-1 PROTEASE)		 3tw8 DENN
DOMAIN-CONTAINING
PROTEIN 1B
RAS-RELATED PROTEIN
RAB-35
(Homo
sapiens) 		5 / 10 ALA B  65
ASP A  76
GLY B  18
VAL B  19
ILE B  38
 None
 0.92A 3oxvB-3tw8B:
undetectable		 3oxvB-3tw8B:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA402_1
(HIV-1 PROTEASE)		 3tw8 DENN
DOMAIN-CONTAINING
PROTEIN 1B
(Homo
sapiens) 		4 / 5 LEU A  99
PRO A  50
VAL A  49
ASP A  42
 None
 1.11A 3ufnA-3tw8A:
undetectable
3ufnB-3tw8A:
undetectable		 3ufnA-3tw8A:
14.29
3ufnB-3tw8A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_A_ACTA1002_0
(PUTATIVE
OXIDOREDUCTASE)		 3tw8 RAS-RELATED PROTEIN
RAB-35
(Homo
sapiens) 		4 / 6 ASP B  16
GLY B  18
VAL B  19
ASP B  89
 None
 1.18A 3vqrA-3tw8B:
undetectable		 3vqrA-3tw8B:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_B_ACTB1002_0
(PUTATIVE
OXIDOREDUCTASE)		 3tw8 RAS-RELATED PROTEIN
RAB-35
(Homo
sapiens) 		4 / 5 ASP B  16
GLY B  18
VAL B  19
ASP B  89
 None
 1.19A 3vqrB-3tw8B:
undetectable		 3vqrB-3tw8B:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_1
(PUTATIVE REGULATORY
PROTEIN)		 3tw8 DENN
DOMAIN-CONTAINING
PROTEIN 1B
(Homo
sapiens) 		3 / 3 TYR A 174
MET A 220
LEU A 191
 None
 0.67A 3vw1D-3tw8A:
undetectable		 3vw1D-3tw8A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_2
(PROTEASE)		 3tw8 DENN
DOMAIN-CONTAINING
PROTEIN 1B
(Homo
sapiens) 		4 / 7 ALA A 240
VAL A 264
TRP A 222
ILE A 225
 None
 0.94A 3wsjB-3tw8A:
undetectable		 3wsjB-3tw8A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3Q_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3tw8 DENN
DOMAIN-CONTAINING
PROTEIN 1B
(Homo
sapiens) 		5 / 7 LEU A 111
VAL A  17
TYR A 118
LEU A 134
TYR A 108
 None
 1.43A 4b3qA-3tw8A:
undetectable		 4b3qA-3tw8A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		 3tw8 DENN
DOMAIN-CONTAINING
PROTEIN 1B
(Homo
sapiens) 		5 / 11 LEU A 261
TYR A 244
VAL A 197
ILE A 248
LEU A 252
 None
 1.46A 4lhmA-3tw8A:
undetectable		 4lhmA-3tw8A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3tw8 DENN
DOMAIN-CONTAINING
PROTEIN 1B
(Homo
sapiens) 		4 / 5 TYR A 135
LEU A  18
ASP A  42
VAL A  73
 None
 1.24A 4nkvA-3tw8A:
undetectable		 4nkvA-3tw8A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 3tw8 RAS-RELATED PROTEIN
RAB-35
(Homo
sapiens) 		5 / 12 ILE B 144
TYR B  88
VAL B  90
LEU B 117
LEU B  24
 None
 0.93A 4qynA-3tw8B:
undetectable		 4qynA-3tw8B:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 3tw8 RAS-RELATED PROTEIN
RAB-35
(Homo
sapiens) 		4 / 8 LYS B 173
THR B 165
PHE B   9
ASP B   6
 None
 1.15A 5t8sB-3tw8B:
undetectable		 5t8sB-3tw8B:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UVM_B_ADNB207_1
(HISTIDINE TRIAD
(HIT) PROTEIN)		 3tw8 RAS-RELATED PROTEIN
RAB-35
(Homo
sapiens) 		5 / 12 VAL B  86
ILE B  14
ILE B  73
ILE B 106
ASN B 107
 None
 0.90A 5uvmB-3tw8B:
undetectable		 5uvmB-3tw8B:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BER_A_DVAA2_0
(E(DVA)DP(DGL)(DHI)(D
PR)N(DAL)(DPR))		 3tw8 RAS-RELATED PROTEIN
RAB-35
(Homo
sapiens) 		3 / 3 GLU B 153
ASP B 124
PRO B 125
 None
 0.48A 6berA-3tw8B:
undetectable		 6berA-3tw8B:
5.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CJK_C_ACTC301_0
(IMMUNOGLOBULIN FAB
LIGHT CHAIN)		 3tw8 RAS-RELATED PROTEIN
RAB-35
(Homo
sapiens) 		4 / 4 VAL B  99
GLY B  15
ASP B  16
ASP B  89
 None
 1.20A 6cjkC-3tw8B:
undetectable		 6cjkC-3tw8B:
22.32