SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3twd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_B_J01B500_1
(ORF12)		 3twd BIFUNCTIONAL PROTEIN
GLMU
(Escherichia
coli) 		5 / 9 VAL A 278
ILE A 292
LEU A 332
GLY A 327
ALA A 330
 None
 1.43A 2xf3B-3twdA:
undetectable		 2xf3B-3twdA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_2
(TUBULIN BETA-2B
CHAIN)		 3twd BIFUNCTIONAL PROTEIN
GLMU
(Escherichia
coli) 		5 / 12 LEU A 338
ALA A 336
ALA A 361
ALA A 342
ILE A 378
 None
 0.69A 4o2bD-3twdA:
undetectable		 4o2bD-3twdA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_2
(TUBULIN BETA-2B
CHAIN)		 3twd BIFUNCTIONAL PROTEIN
GLMU
(Escherichia
coli) 		5 / 12 LEU A 338
LEU A 367
ALA A 361
ALA A 342
ILE A 378
 None
 0.84A 4o2bD-3twdA:
undetectable		 4o2bD-3twdA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_2
(TUBULIN BETA CHAIN)		 3twd BIFUNCTIONAL PROTEIN
GLMU
(Escherichia
coli) 		5 / 12 LEU A 367
ALA A 353
ALA A 342
VAL A 344
ALA A 361
 None
 1.11A 4x1iB-3twdA:
undetectable		 4x1iB-3twdA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_B_LOCB502_1
(TUBULIN BETA CHAIN)		 3twd BIFUNCTIONAL PROTEIN
GLMU
(Escherichia
coli) 		5 / 12 LEU A 338
ALA A 336
ALA A 361
ALA A 342
ILE A 378
 None
 0.91A 4x20B-3twdA:
undetectable		 4x20B-3twdA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_B_LOCB502_1
(TUBULIN BETA CHAIN)		 3twd BIFUNCTIONAL PROTEIN
GLMU
(Escherichia
coli) 		5 / 12 LEU A 338
LEU A 367
ALA A 361
ALA A 342
ILE A 378
 None
 0.93A 4x20B-3twdA:
undetectable		 4x20B-3twdA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_B_LOCB502_1
(TUBULIN BETA CHAIN)		 3twd BIFUNCTIONAL PROTEIN
GLMU
(Escherichia
coli) 		5 / 12 LEU A 367
ALA A 353
ALA A 342
VAL A 344
ALA A 361
 None
 0.93A 4x20B-3twdA:
undetectable		 4x20B-3twdA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_A_ILEA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 3twd BIFUNCTIONAL PROTEIN
GLMU
(Escherichia
coli) 		4 / 6 THR A 285
VAL A 284
VAL A 290
HIS A 268
 None
 1.02A 5eclA-3twdA:
undetectable		 5eclA-3twdA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_D_ILED602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 3twd BIFUNCTIONAL PROTEIN
GLMU
(Escherichia
coli) 		4 / 6 ILE A 303
THR A 285
VAL A 284
VAL A 272
 None
 0.91A 5eclD-3twdA:
undetectable		 5eclD-3twdA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_2
(TUBULIN BETA CHAIN)		 3twd BIFUNCTIONAL PROTEIN
GLMU
(Escherichia
coli) 		5 / 12 LEU A 338
LEU A 367
ALA A 361
ALA A 342
ILE A 378
 None
 0.80A 5eypB-3twdA:
undetectable		 5eypB-3twdA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 3twd BIFUNCTIONAL PROTEIN
GLMU
(Escherichia
coli) 		3 / 3 ALA A 318
ASN A 319
LEU A 320
 None
 0.45A 5i1pD-3twdA:
undetectable		 5i1pD-3twdA:
8.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_1
(METHYLTRANSFERASE)		 3twd BIFUNCTIONAL PROTEIN
GLMU
(Escherichia
coli) 		4 / 7 GLY A 373
SER A 359
GLU A 371
ASP A 374
 None
 1.11A 5n5dB-3twdA:
undetectable		 5n5dB-3twdA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_2
(TUBULIN BETA-2B
CHAIN)		 3twd BIFUNCTIONAL PROTEIN
GLMU
(Escherichia
coli) 		5 / 12 LEU A 338
LEU A 367
ALA A 361
ALA A 342
ILE A 378
 None
 0.78A 5nm5B-3twdA:
undetectable		 5nm5B-3twdA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA504_1
(-)		 3twd BIFUNCTIONAL PROTEIN
GLMU
(Escherichia
coli) 		4 / 8 VAL A 401
ILE A 378
ALA A 370
THR A 395
 None
 0.76A 5og9A-3twdA:
undetectable		 5og9A-3twdA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_B_LOCB504_2
(TUBULIN BETA CHAIN)		 3twd BIFUNCTIONAL PROTEIN
GLMU
(Escherichia
coli) 		5 / 12 LEU A 338
LEU A 367
ALA A 361
ALA A 342
ILE A 378
 None
 0.83A 5xiwB-3twdA:
undetectable		 5xiwB-3twdA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_1
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 3twd BIFUNCTIONAL PROTEIN
GLMU
(Escherichia
coli) 		4 / 6 SER A 301
ARG A 331
ASP A 369
ASP A 317
 None
 1.07A 5zw4A-3twdA:
undetectable		 5zw4A-3twdA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_B_SAMB401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)		 3twd BIFUNCTIONAL PROTEIN
GLMU
(Escherichia
coli) 		5 / 12 LEU A 339
GLY A 356
VAL A 415
VAL A 401
ASP A 400
 None
 1.36A 6bxlB-3twdA:
undetectable		 6bxlB-3twdA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_1
(CYTOCHROME P450 1A1)		 3twd BIFUNCTIONAL PROTEIN
GLMU
(Escherichia
coli) 		4 / 7 SER A 359
GLY A 398
VAL A 427
LEU A 409
 None
 0.82A 6dwnB-3twdA:
undetectable		 6dwnB-3twdA:
15.62