SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3twi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_B_NDRB2001_0
(PROGESTERONE
RECEPTOR)		 3twi VARIABLE LYMPHOCYTE
RECEPTOR B
(Petromyzon
marinus) 		5 / 12 LEU D 102
LEU D  78
LEU D  54
LEU D  88
LEU D  85
 None
 0.96A 1sqnB-3twiD:
undetectable		 1sqnB-3twiD:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_A_THHA401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 3twi VARIABLE LYMPHOCYTE
RECEPTOR B
(Petromyzon
marinus) 		5 / 12 LEU D 102
LEU D 120
PRO D  48
THR D  32
THR D  76
 None
 1.18A 3dcjA-3twiD:
undetectable
3dcjB-3twiD:
undetectable		 3dcjA-3twiD:
22.87
3dcjB-3twiD:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3twi VARIABLE LYMPHOCYTE
RECEPTOR B
(Petromyzon
marinus) 		5 / 12 ILE D 106
LEU D  54
ILE D  61
LEU D  64
VAL D  92
 None
 1.02A 3w68B-3twiD:
undetectable		 3w68B-3twiD:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 3twi VARIABLE LYMPHOCYTE
RECEPTOR B
(Petromyzon
marinus) 		4 / 4 ASN D  34
SER D  42
LEU D  40
THR D  32
 None
 1.41A 4an2A-3twiD:
undetectable		 4an2A-3twiD:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3twi VARIABLE LYMPHOCYTE
RECEPTOR B
(Petromyzon
marinus) 		5 / 12 PHE D  93
ILE D  47
LEU D  64
LEU D  80
LEU D  56
 None
GOL  D   2 (-3.5A)
None
None
None
 1.24A 4xumA-3twiD:
undetectable		 4xumA-3twiD:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_0
(REGULATORY PROTEIN
TETR)		 3twi VARIABLE LYMPHOCYTE
RECEPTOR B
(Petromyzon
marinus) 		5 / 12 ALA D  45
LEU D  40
ILE D  61
VAL D  68
PHE D  69
 None
None
None
GOL  D   2 ( 4.2A)
None
 1.13A 5vlmB-3twiD:
undetectable		 5vlmB-3twiD:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_0
(REGULATORY PROTEIN
TETR)		 3twi VARIABLE LYMPHOCYTE
RECEPTOR B
(Petromyzon
marinus) 		5 / 12 ALA D  45
LEU D  40
ILE D  61
VAL D  68
PHE D  69
 None
None
None
GOL  D   2 ( 4.2A)
None
 1.12A 5vlmE-3twiD:
undetectable		 5vlmE-3twiD:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_0
(REGULATORY PROTEIN
TETR)		 3twi VARIABLE LYMPHOCYTE
RECEPTOR B
(Petromyzon
marinus) 		5 / 12 ALA D  45
LEU D  40
ILE D  61
VAL D  68
PHE D  69
 None
None
None
GOL  D   2 ( 4.2A)
None
 1.26A 5vlmG-3twiD:
undetectable		 5vlmG-3twiD:
20.77