SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3twk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_B_FLPB2650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 3twk FORMAMIDOPYRIMIDINE-
DNA GLYCOSYLASE 1
(Arabidopsis
thaliana) 		5 / 12 LEU A 193
ILE A 169
ALA A 204
SER A 206
LEU A 207
 None
 1.02A 1cqeB-3twkA:
undetectable		 1cqeB-3twkA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_B_SAMB200_0
(METHIONINE REPRESSOR)		 3twk FORMAMIDOPYRIMIDINE-
DNA GLYCOSYLASE 1
(Arabidopsis
thaliana) 		5 / 11 HIS A  36
PHE A  43
GLY A  37
LEU A 134
PRO A 137
 None
 1.39A 1mjqA-3twkA:
undetectable
1mjqB-3twkA:
undetectable		 1mjqA-3twkA:
18.73
1mjqB-3twkA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_H_SAMH200_0
(METHIONINE REPRESSOR)		 3twk FORMAMIDOPYRIMIDINE-
DNA GLYCOSYLASE 1
(Arabidopsis
thaliana) 		5 / 10 HIS A  36
PHE A  43
GLY A  37
LEU A 134
PRO A 137
 None
 1.39A 1mjqG-3twkA:
undetectable
1mjqH-3twkA:
undetectable		 1mjqG-3twkA:
18.73
1mjqH-3twkA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3twk FORMAMIDOPYRIMIDINE-
DNA GLYCOSYLASE 1
(Arabidopsis
thaliana) 		4 / 6 PHE A 110
VAL A 112
LEU A 114
SER A  95
 None
 1.07A 1wrlB-3twkA:
undetectable		 1wrlB-3twkA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1200_1
(SERUM ALBUMIN)		 3twk FORMAMIDOPYRIMIDINE-
DNA GLYCOSYLASE 1
(Arabidopsis
thaliana) 		4 / 4 LEU A 215
ILE A 181
ILE A 184
ALA A 189
 None
 0.83A 2i30A-3twkA:
undetectable		 2i30A-3twkA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3twk FORMAMIDOPYRIMIDINE-
DNA GLYCOSYLASE 1
(Arabidopsis
thaliana) 		5 / 12 LEU A 193
ILE A 169
ALA A 204
SER A 206
LEU A 207
 None
 1.05A 3n8xB-3twkA:
undetectable		 3n8xB-3twkA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU6_B_478B401_2
(PROTEASE)		 3twk FORMAMIDOPYRIMIDINE-
DNA GLYCOSYLASE 1
(Arabidopsis
thaliana) 		5 / 10 LEU A 151
VAL A 222
GLY A 185
VAL A 227
ILE A 223
 None
 1.04A 3nu6B-3twkA:
undetectable		 3nu6B-3twkA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP1_A_ACTA590_0
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 3twk FORMAMIDOPYRIMIDINE-
DNA GLYCOSYLASE 1
(Arabidopsis
thaliana) 		4 / 5 GLU A   3
LEU A   4
GLN A 178
GLY A  59
 None
 1.00A 3pp1A-3twkA:
undetectable		 3pp1A-3twkA:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 3twk FORMAMIDOPYRIMIDINE-
DNA GLYCOSYLASE 1
(Arabidopsis
thaliana) 		3 / 3 GLN A 202
THR A 203
THR A 170
 None
 0.80A 4fu9A-3twkA:
undetectable		 4fu9A-3twkA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		 3twk FORMAMIDOPYRIMIDINE-
DNA GLYCOSYLASE 1
(Arabidopsis
thaliana) 		5 / 12 LEU A  64
LEU A   4
GLU A  15
ILE A  14
ALA A  13
 None
 1.00A 4ltwA-3twkA:
undetectable		 4ltwA-3twkA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_CQAB303_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 3twk FORMAMIDOPYRIMIDINE-
DNA GLYCOSYLASE 1
(Arabidopsis
thaliana) 		4 / 8 GLY A 147
GLY A  59
GLU A   8
LEU A 151
 None
 0.74A 4mwzB-3twkA:
undetectable		 4mwzB-3twkA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_2
(TUBULIN BETA-2B
CHAIN)		 3twk FORMAMIDOPYRIMIDINE-
DNA GLYCOSYLASE 1
(Arabidopsis
thaliana) 		5 / 12 CYH A  18
LEU A  19
LEU A 114
LEU A  64
ILE A  84
 None
 1.10A 4o2bB-3twkA:
undetectable		 4o2bB-3twkA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 3twk FORMAMIDOPYRIMIDINE-
DNA GLYCOSYLASE 1
(Arabidopsis
thaliana) 		3 / 3 SER A 233
ALA A 226
VAL A 227
 None
 0.55A 4x1iA-3twkA:
undetectable		 4x1iA-3twkA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		 3twk FORMAMIDOPYRIMIDINE-
DNA GLYCOSYLASE 1
(Arabidopsis
thaliana) 		4 / 6 ALA A 161
LEU A 207
SER A 208
VAL A 157
 None
None
GOL  A 302 (-4.8A)
None
 1.29A 5a6iA-3twkA:
undetectable		 5a6iA-3twkA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD9_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3twk FORMAMIDOPYRIMIDINE-
DNA GLYCOSYLASE 1
(Arabidopsis
thaliana) 		4 / 7 VAL A 222
TRP A 240
PHE A 236
HIS A 243
 None
 1.44A 5ad9A-3twkA:
undetectable
5ad9B-3twkA:
undetectable		 5ad9A-3twkA:
21.86
5ad9B-3twkA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 3twk FORMAMIDOPYRIMIDINE-
DNA GLYCOSYLASE 1
(Arabidopsis
thaliana) 		3 / 3 SER A 233
ALA A 226
VAL A 227
 None
 0.55A 5eypA-3twkA:
undetectable		 5eypA-3twkA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ITZ_B_LOCB502_1
(TUBULIN BETA-2B
CHAIN)		 3twk FORMAMIDOPYRIMIDINE-
DNA GLYCOSYLASE 1
(Arabidopsis
thaliana) 		5 / 12 CYH A  18
LEU A  19
LEU A 114
LEU A  64
ILE A  84
 None
 1.07A 5itzB-3twkA:
undetectable		 5itzB-3twkA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_1
(PROTEASE E35D-DRV)		 3twk FORMAMIDOPYRIMIDINE-
DNA GLYCOSYLASE 1
(Arabidopsis
thaliana) 		5 / 12 LEU A 151
VAL A 222
GLY A 185
VAL A 227
ILE A 223
 None
 1.14A 5kqyA-3twkA:
undetectable		 5kqyA-3twkA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIO_B_LOCB502_1
(TUBULIN BETA CHAIN)		 3twk FORMAMIDOPYRIMIDINE-
DNA GLYCOSYLASE 1
(Arabidopsis
thaliana) 		5 / 12 CYH A  18
LEU A  19
LEU A 114
LEU A  64
ILE A  84
 None
 1.05A 5mioB-3twkA:
undetectable		 5mioB-3twkA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_B_REAB503_1
(RETINOIC ACID
RECEPTOR BETA)		 3twk FORMAMIDOPYRIMIDINE-
DNA GLYCOSYLASE 1
(Arabidopsis
thaliana) 		5 / 12 PHE A 110
PHE A  43
SER A  46
PHE A  74
LEU A  62
 None
 1.25A 5uanB-3twkA:
undetectable		 5uanB-3twkA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIL_B_TPVB201_1
(HIV-1 PROTEASE)		 3twk FORMAMIDOPYRIMIDINE-
DNA GLYCOSYLASE 1
(Arabidopsis
thaliana) 		6 / 12 LEU A 151
VAL A 222
GLY A 185
PRO A   5
VAL A 227
ILE A 223
 None
 1.39A 6dilB-3twkA:
undetectable		 6dilB-3twkA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_0
(PEPTIDYLPROLYL
ISOMERASE)		 3twk FORMAMIDOPYRIMIDINE-
DNA GLYCOSYLASE 1
(Arabidopsis
thaliana) 		4 / 4 ASP A 149
ILE A 143
PRO A 142
LEU A 146
 None
 0.99A 6mkeB-3twkA:
undetectable		 6mkeB-3twkA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_D_FK5D201_0
(PEPTIDYLPROLYL
ISOMERASE)		 3twk FORMAMIDOPYRIMIDINE-
DNA GLYCOSYLASE 1
(Arabidopsis
thaliana) 		4 / 4 ASP A 149
ILE A 143
PRO A 142
LEU A 146
 None
 0.95A 6mkeA-3twkA:
undetectable		 6mkeA-3twkA:
13.47