SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3two'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_A_PPFA410_1
(PHOSPHONOACETATE
HYDROLASE)		 3two MANNITOL
DEHYDROGENASE
(Helicobacter
pylori) 		4 / 5 ASP A 120
HIS A 128
HIS A 123
HIS A  25
 None
 1.24A 1ei6A-3twoA:
undetectable		 1ei6A-3twoA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBO_A_CAMA442_0
(CYTOCHROME P450-CAM)		 3two MANNITOL
DEHYDROGENASE
(Helicobacter
pylori) 		5 / 10 VAL A  85
VAL A  86
VAL A 303
ASP A 304
ILE A 307
 None
 1.19A 2qboA-3twoA:
undetectable		 2qboA-3twoA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 3two MANNITOL
DEHYDROGENASE
(Helicobacter
pylori) 		5 / 12 ILE A 296
GLY A 294
ASP A 304
VAL A 303
GLY A  89
 None
 0.89A 2qe6A-3twoA:
4.5		 2qe6A-3twoA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXT_A_SAMA397_0
(PROBABLE
N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE
TRM1)		 3two MANNITOL
DEHYDROGENASE
(Helicobacter
pylori) 		5 / 12 LEU A 188
ILE A 238
ILE A 163
SER A 167
ALA A 161
 NDP  A 601 (-3.5A)
None
None
None
None
 1.18A 3axtA-3twoA:
6.8		 3axtA-3twoA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		 3two MANNITOL
DEHYDROGENASE
(Helicobacter
pylori) 		4 / 8 HIS A  25
HIS A 123
ASP A  31
GLY A  28
 None
 0.91A 3c0zB-3twoA:
undetectable		 3c0zB-3twoA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3two MANNITOL
DEHYDROGENASE
(Helicobacter
pylori) 		3 / 3 TYR A 142
ASP A 120
ASP A 124
 None
 0.92A 3ou6B-3twoA:
6.9		 3ou6B-3twoA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 3two MANNITOL
DEHYDROGENASE
(Helicobacter
pylori) 		4 / 5 LEU A 152
GLY A  68
ILE A 144
VAL A 143
 None
 0.87A 3wriA-3twoA:
undetectable		 3wriA-3twoA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 3two MANNITOL
DEHYDROGENASE
(Helicobacter
pylori) 		4 / 5 LEU A 152
GLY A  68
ILE A 144
VAL A 143
 None
 0.87A 3wriB-3twoA:
undetectable		 3wriB-3twoA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF2_A_4CHA506_0
(NADPH DEHYDROGENASE)		 3two MANNITOL
DEHYDROGENASE
(Helicobacter
pylori) 		4 / 6 TYR A 132
HIS A  43
TYR A 327
TYR A 116
 None
NDP  A 601 (-4.0A)
None
None
 1.44A 4df2A-3twoA:
undetectable		 4df2A-3twoA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 3two MANNITOL
DEHYDROGENASE
(Helicobacter
pylori) 		5 / 12 VAL A 180
ILE A 242
GLY A 189
GLY A 184
LEU A 169
 None
NDP  A 601 (-3.9A)
None
NDP  A 601 (-3.3A)
None
 1.05A 4mwzB-3twoA:
7.0		 4mwzB-3twoA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDR_A_ADNA402_1
(FAD:PROTEIN FMN
TRANSFERASE)		 3two MANNITOL
DEHYDROGENASE
(Helicobacter
pylori) 		5 / 12 LEU A 158
VAL A 303
GLY A  87
ALA A  67
PRO A 313
 None
 1.00A 4xdrA-3twoA:
undetectable		 4xdrA-3twoA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_A_CL6A502_1
(CYTOCHROME P-450)		 3two MANNITOL
DEHYDROGENASE
(Helicobacter
pylori) 		4 / 5 ALA A 161
THR A 165
VAL A 182
ILE A 239
 None
 0.93A 4xe3A-3twoA:
undetectable		 4xe3A-3twoA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_B_SAMB303_0
(CATECHOL
O-METHYLTRANSFERASE)		 3two MANNITOL
DEHYDROGENASE
(Helicobacter
pylori) 		5 / 12 VAL A 264
GLY A 294
SER A 291
ILE A 296
GLN A 300
 NDP  A 601 (-4.0A)
None
None
None
None
 1.14A 4xueB-3twoA:
6.3		 4xueB-3twoA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3two MANNITOL
DEHYDROGENASE
(Helicobacter
pylori) 		3 / 3 THR A 299
HIS A  43
LEU A 188
 None
NDP  A 601 (-4.0A)
NDP  A 601 (-3.5A)
 0.77A 5axdA-3twoA:
5.5		 5axdA-3twoA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_G_IPHG101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 3two MANNITOL
DEHYDROGENASE
(Helicobacter
pylori) 		4 / 6 HIS A  47
LEU A 266
CYH A  42
LEU A 188
 NDP  A 601 (-4.0A)
NDP  A 601 (-4.7A)
ZN  A 350 ( 2.5A)
NDP  A 601 (-3.5A)
 1.49A 5hrqD-3twoA:
undetectable
5hrqG-3twoA:
undetectable
5hrqH-3twoA:
undetectable		 5hrqD-3twoA:
8.71
5hrqG-3twoA:
5.52
5hrqH-3twoA:
8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_1
(METHYLTRANSFERASE)		 3two MANNITOL
DEHYDROGENASE
(Helicobacter
pylori) 		4 / 7 PHE A 337
ILE A  41
ASP A 316
ASN A 329
 None
 0.94A 5n5dA-3twoA:
7.7		 5n5dA-3twoA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_D_ACTD301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 3two MANNITOL
DEHYDROGENASE
(Helicobacter
pylori) 		4 / 4 ASP A 120
HIS A 123
HIS A  25
HIS A 128
 None
 1.19A 5ncdD-3twoA:
2.1		 5ncdD-3twoA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUK_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 3two MANNITOL
DEHYDROGENASE
(Helicobacter
pylori) 		5 / 10 VAL A  77
LYS A  81
ILE A  70
ILE A  34
VAL A 137
 None
 1.16A 5nukA-3twoA:
undetectable		 5nukA-3twoA:
11.97