SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tx1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H77_A_T3A1_1
(THRA PROTEIN)		 3tx1 UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE
(Listeria
monocytogenes) 		5 / 12 ILE A  86
ALA A  99
ALA A 129
LEU A 101
ILE A 141
 None
None
FAD  A 299 (-4.0A)
None
None
 1.10A 2h77A-3tx1A:
undetectable		 2h77A-3tx1A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBL_A_CAMA517_0
(CYTOCHROME P450-CAM)		 3tx1 UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE
(Listeria
monocytogenes) 		4 / 7 PHE A 222
LEU A 239
VAL A 279
THR A 278
 None
 0.92A 2qblA-3tx1A:
undetectable		 2qblA-3tx1A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX7_A_SALA1336_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3tx1 UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE
(Listeria
monocytogenes) 		4 / 8 SER A 237
THR A 278
VAL A 279
LEU A 287
 None
 0.99A 3ax7A-3tx1A:
7.5		 3ax7A-3tx1A:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3tx1 UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE
(Listeria
monocytogenes) 		3 / 3 ILE A 257
PHE A 222
HIS A 242
 None
 0.68A 3h0aA-3tx1A:
undetectable		 3h0aA-3tx1A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_B_VORB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 3tx1 UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE
(Listeria
monocytogenes) 		5 / 11 LEU A 145
PHE A 186
ILE A 141
ALA A  95
ALA A 129
 None
None
None
None
FAD  A 299 (-4.0A)
 1.10A 3mdtB-3tx1A:
undetectable		 3mdtB-3tx1A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_B_NCAB192_0
(NICOTINAMIDASE)		 3tx1 UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE
(Listeria
monocytogenes) 		5 / 11 ASP A 103
LEU A 116
PHE A 186
LEU A 101
ILE A 126
 None
 1.28A 3o94B-3tx1A:
undetectable		 3o94B-3tx1A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_C_NCAC192_0
(NICOTINAMIDASE)		 3tx1 UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE
(Listeria
monocytogenes) 		5 / 11 ASP A 103
LEU A 116
PHE A 186
LEU A 101
ILE A 126
 None
 1.27A 3o94C-3tx1A:
undetectable		 3o94C-3tx1A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_D_NCAD192_0
(NICOTINAMIDASE)		 3tx1 UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE
(Listeria
monocytogenes) 		5 / 11 ASP A 103
LEU A 116
PHE A 186
LEU A 101
ILE A 126
 None
 1.27A 3o94D-3tx1A:
undetectable		 3o94D-3tx1A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_B_LOCB502_1
(TUBULIN BETA CHAIN)		 3tx1 UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE
(Listeria
monocytogenes) 		5 / 12 ALA A  99
LEU A 101
ALA A 105
ILE A  93
LYS A 106
 None
 1.17A 3ut5B-3tx1A:
undetectable		 3ut5B-3tx1A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3tx1 UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE
(Listeria
monocytogenes) 		4 / 8 ILE A  73
ILE A  68
SER A 125
GLY A  63
 None
None
FAD  A 299 (-2.8A)
FAD  A 299 (-3.0A)
 0.67A 4acaC-3tx1A:
undetectable		 4acaC-3tx1A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3tx1 UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE
(Listeria
monocytogenes) 		4 / 8 ILE A  73
ILE A  68
SER A 125
GLY A  63
 None
None
FAD  A 299 (-2.8A)
FAD  A 299 (-3.0A)
 0.67A 4acbC-3tx1A:
undetectable		 4acbC-3tx1A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN)		 3tx1 UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE
(Listeria
monocytogenes) 		5 / 12 ARG A 170
SER A 220
GLY A 219
GLN A 211
ALA A 119
 GOL  A 301 (-4.3A)
SO4  A 303 ( 3.5A)
FAD  A 299 (-3.3A)
FAD  A 299 ( 4.5A)
None
 1.28A 4r29A-3tx1A:
undetectable		 4r29A-3tx1A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_D_ADND303_1
(5'/3'-NUCLEOTIDASE
SURE)		 3tx1 UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE
(Listeria
monocytogenes) 		5 / 10 LEU A 116
LEU A 188
GLY A 115
ALA A 184
ILE A  93
 None
 0.93A 4xj7C-3tx1A:
undetectable
4xj7D-3tx1A:
undetectable		 4xj7C-3tx1A:
25.29
4xj7D-3tx1A:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF402_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3tx1 UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE
(Listeria
monocytogenes) 		4 / 7 LEU A 188
ALA A  95
LEU A 116
ALA A 108
 None
 0.64A 4z90F-3tx1A:
undetectable
4z90G-3tx1A:
undetectable
4z90H-3tx1A:
undetectable
4z90J-3tx1A:
undetectable		 4z90F-3tx1A:
19.94
4z90G-3tx1A:
19.94
4z90H-3tx1A:
19.94
4z90J-3tx1A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 3tx1 UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE
(Listeria
monocytogenes) 		5 / 12 VAL A 181
ALA A 184
PHE A 186
GLY A 124
LEU A 101
 FAD  A 299 (-3.8A)
None
None
FAD  A 299 (-3.6A)
None
 1.20A 5m54E-3tx1A:
undetectable		 5m54E-3tx1A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_C_CHDC401_0
(BILE SALT HYDROLASE)		 3tx1 UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE
(Listeria
monocytogenes) 		4 / 8 LEU A 116
ILE A  86
ALA A 129
LEU A 130
 None
None
FAD  A 299 (-4.0A)
None
 0.67A 5y7pC-3tx1A:
undetectable		 5y7pC-3tx1A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9A_A_AR3A201_1
(PEPTIDYL-TRNA
HYDROLASE)		 3tx1 UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE
(Listeria
monocytogenes) 		4 / 6 ALA A 108
LYS A 193
GLN A 197
ASP A 201
 None
 1.44A 5y9aA-3tx1A:
undetectable		 5y9aA-3tx1A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I5Z_D_SAMD401_0
(O-METHYLTRANSFERASE
1)		 3tx1 UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE
(Listeria
monocytogenes) 		5 / 11 SER A  64
GLY A  98
GLY A 127
LEU A 182
VAL A 181
 FAD  A 299 (-2.7A)
None
FAD  A 299 (-3.2A)
None
FAD  A 299 (-3.8A)
 1.20A 6i5zD-3tx1A:
undetectable		 6i5zD-3tx1A:
23.61