SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tx2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3003_1
(SERUM ALBUMIN)		 3tx2 PROBABLE
6-PHOSPHOGLUCONOLACT
ONASE
(Mycobacteroides
abscessus) 		3 / 4 LYS A 207
ALA A 210
MET A 148
 None
 0.74A 1hk3A-3tx2A:
undetectable		 1hk3A-3tx2A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA444_1
(ALPHA AMYLASE)		 3tx2 PROBABLE
6-PHOSPHOGLUCONOLACT
ONASE
(Mycobacteroides
abscessus) 		4 / 7 TYR A 124
ASN A  84
HIS A 153
GLY A  44
 None
 1.20A 1mxgA-3tx2A:
undetectable		 1mxgA-3tx2A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_1
(HEMK PROTEIN)		 3tx2 PROBABLE
6-PHOSPHOGLUCONOLACT
ONASE
(Mycobacteroides
abscessus) 		3 / 3 ASP A 142
PHE A  69
ASN A  65
 None
None
NA  A 248 (-3.4A)
 0.62A 1sg9B-3tx2A:
undetectable		 1sg9B-3tx2A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_B_SALB1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3tx2 PROBABLE
6-PHOSPHOGLUCONOLACT
ONASE
(Mycobacteroides
abscessus) 		4 / 8 SER A 203
THR A  46
ALA A  18
ALA A  19
 None
 0.74A 3ax9B-3tx2A:
undetectable		 3ax9B-3tx2A:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_H_SAMH300_0
(PUTATIVE RRNA
METHYLASE)		 3tx2 PROBABLE
6-PHOSPHOGLUCONOLACT
ONASE
(Mycobacteroides
abscessus) 		6 / 12 GLY A  71
ASN A 155
ASP A  73
ILE A  39
ASN A  84
LEU A 146
 None
 1.36A 3eeyH-3tx2A:
4.3		 3eeyH-3tx2A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_I_SAMI300_0
(PUTATIVE RRNA
METHYLASE)		 3tx2 PROBABLE
6-PHOSPHOGLUCONOLACT
ONASE
(Mycobacteroides
abscessus) 		6 / 12 GLY A  71
ASN A 155
ASP A  73
ILE A  39
ASN A  84
LEU A 146
 None
 1.35A 3eeyI-3tx2A:
4.9		 3eeyI-3tx2A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3tx2 PROBABLE
6-PHOSPHOGLUCONOLACT
ONASE
(Mycobacteroides
abscessus) 		4 / 8 SER A 203
THR A  46
ALA A  18
ALA A  19
 None
 0.74A 3ns1L-3tx2A:
undetectable		 3ns1L-3tx2A:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQB_A_FOLA2001_0
(DIHYDROFOLATE
REDUCTASE)		 3tx2 PROBABLE
6-PHOSPHOGLUCONOLACT
ONASE
(Mycobacteroides
abscessus) 		5 / 11 ALA A 225
LEU A 200
THR A   4
ILE A   6
LEU A 246
 None
 1.00A 3tqbA-3tx2A:
undetectable		 3tqbA-3tx2A:
21.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TX2_A_BEZA251_0
(PROBABLE
6-PHOSPHOGLUCONOLACT
ONASE)		 3tx2 PROBABLE
6-PHOSPHOGLUCONOLACT
ONASE
(Mycobacteroides
abscessus) 		4 / 7 ALA A  88
TRP A  86
TRP A  89
MET A 103
 None
None
BEZ  A 251 ( 4.2A)
BEZ  A 251 ( 4.0A)
 1.39A 3tx2A-3tx2A:
49.0		 3tx2A-3tx2A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TX2_A_BEZA251_0
(PROBABLE
6-PHOSPHOGLUCONOLACT
ONASE)		 3tx2 PROBABLE
6-PHOSPHOGLUCONOLACT
ONASE
(Mycobacteroides
abscessus) 		6 / 7 ARG A  83
ALA A  85
TRP A  86
TRP A  89
MET A 103
ALA A 105
 BEZ  A 251 (-4.0A)
BEZ  A 251 ( 3.7A)
None
BEZ  A 251 ( 4.2A)
BEZ  A 251 ( 4.0A)
BEZ  A 251 (-3.5A)
 0.00A 3tx2A-3tx2A:
49.0		 3tx2A-3tx2A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TX2_A_BEZA251_0
(PROBABLE
6-PHOSPHOGLUCONOLACT
ONASE)		 3tx2 PROBABLE
6-PHOSPHOGLUCONOLACT
ONASE
(Mycobacteroides
abscessus) 		5 / 7 LYS A  78
ARG A  83
ALA A  85
TRP A  86
TRP A  89
 BEZ  A 251 (-3.7A)
BEZ  A 251 (-4.0A)
BEZ  A 251 ( 3.7A)
None
BEZ  A 251 ( 4.2A)
 0.74A 3tx2A-3tx2A:
49.0		 3tx2A-3tx2A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_1
(MDR769 HIV-1
PROTEASE)		 3tx2 PROBABLE
6-PHOSPHOGLUCONOLACT
ONASE
(Mycobacteroides
abscessus) 		5 / 11 ARG A  74
ALA A 163
ASP A 162
PRO A 178
VAL A 174
 None
 1.05A 4l1aA-3tx2A:
undetectable		 4l1aA-3tx2A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_A_SAMA301_0
(PUTATIVE RNA
METHYLASE)		 3tx2 PROBABLE
6-PHOSPHOGLUCONOLACT
ONASE
(Mycobacteroides
abscessus) 		5 / 12 GLY A  71
ASN A 155
ASP A  73
ILE A  39
ASN A  84
 None
 1.17A 4pooA-3tx2A:
undetectable		 4pooA-3tx2A:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 3tx2 PROBABLE
6-PHOSPHOGLUCONOLACT
ONASE
(Mycobacteroides
abscessus) 		5 / 12 LEU A  61
GLU A 133
VAL A  96
LEU A  92
PHE A  98
 None
 1.11A 4y0qA-3tx2A:
undetectable		 4y0qA-3tx2A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		 3tx2 PROBABLE
6-PHOSPHOGLUCONOLACT
ONASE
(Mycobacteroides
abscessus) 		4 / 6 VAL A 143
LEU A  54
ILE A  27
ALA A  26
 None
 0.64A 4zf8A-3tx2A:
undetectable		 4zf8A-3tx2A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_A_DESA601_1
(ESTROGEN RECEPTOR)		 3tx2 PROBABLE
6-PHOSPHOGLUCONOLACT
ONASE
(Mycobacteroides
abscessus) 		5 / 12 ALA A  19
LEU A 145
LEU A  50
LEU A  54
LEU A 237
 None
 1.00A 4zn7A-3tx2A:
undetectable		 4zn7A-3tx2A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_B_ACTB1321_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT)		 3tx2 PROBABLE
6-PHOSPHOGLUCONOLACT
ONASE
(Mycobacteroides
abscessus) 		3 / 3 THR A 161
ASP A 162
ALA A 163
 None
 0.06A 5g5gB-3tx2A:
undetectable		 5g5gB-3tx2A:
25.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZX_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 3tx2 PROBABLE
6-PHOSPHOGLUCONOLACT
ONASE
(Mycobacteroides
abscessus) 		4 / 8 THR A 234
GLN A 193
ILE A 192
GLY A 230
 None
 0.93A 5nzxA-3tx2A:
undetectable		 5nzxA-3tx2A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 3tx2 PROBABLE
6-PHOSPHOGLUCONOLACT
ONASE
(Mycobacteroides
abscessus) 		4 / 7 THR A 234
GLN A 193
ILE A 192
GLY A 230
 None
 0.98A 5nzyA-3tx2A:
undetectable		 5nzyA-3tx2A:
22.69