SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tx7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2AVD_B_SAMB601_1 (CATECHOL-O-METHYLTRA NSFERASE)	3tx7	NUCLEAR RECEPTOR SUBFAMILY 5 GROUP A MEMBER 2 (Homo sapiens)	3 / 3	SER B 362 GLU B 312 ASP B 389	None	0.78A	2avdB-3tx7B: undetectable	2avdB-3tx7B: 20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2JFA_B_RALB600_1 (ESTROGEN RECEPTOR)	3tx7	NUCLEAR RECEPTOR SUBFAMILY 5 GROUP A MEMBER 2 (Homo sapiens)	6 / 12	ALA B 349 ASP B 350 LEU B 353 LEU B 386 ARG B 393 LEU B 517	P6L B 100 ( 3.9A) None None P6L B 100 (-3.8A) None P6L B 100 (-4.1A)	1.18A	2jfaB-3tx7B: 19.2	2jfaB-3tx7B: 23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K6I_A_9RAA500_1 (RETINOIC ACID RECEPTOR RXR-ALPHA)	3tx7	NUCLEAR RECEPTOR SUBFAMILY 5 GROUP A MEMBER 2 (Homo sapiens)	5 / 12	ALA B 349 LEU B 386 ILE B 387 ARG B 393 LEU B 405	P6L B 100 ( 3.9A) P6L B 100 (-3.8A) None None None	0.80A	4k6iA-3tx7B: 21.7	4k6iA-3tx7B: 28.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4LTW_A_486A302_1 (ANCESTRAL STEROID RECEPTOR 2)	3tx7	NUCLEAR RECEPTOR SUBFAMILY 5 GROUP A MEMBER 2 (Homo sapiens)	6 / 12	LEU B 353 VAL B 357 GLN B 374 GLN B 379 GLU B 534 ALA B 538	None	0.52A	4ltwA-3tx7B: 19.4	4ltwA-3tx7B: 24.23

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2AVD_B_SAMB601_1","CATECHOL-O-METHYLTRANSFERASE","3tx7","NUCLEAR RECEPTOR SUBFAMILY 5 GROUP A MEMBER 2","Homo sapiens",3,"SER B 362;GLU B 312;ASP B 389","None","0.78A","2avdB-3tx7B:undetectable","2avdB-3tx7B:20.82"],["2JFA_B_RALB600_1","ESTROGEN RECEPTOR","3tx7","NUCLEAR RECEPTOR SUBFAMILY 5 GROUP A MEMBER 2","Homo sapiens",6,"ALA B 349;ASP B 350;LEU B 353;LEU B 386;ARG B 393;LEU B 517","P6L B 100 ( 3.9A);None;None;P6L B 100 (-3.8A);None;P6L B 100 (-4.1A)","1.18A","2jfaB-3tx7B:19.2","2jfaB-3tx7B:23.25"],["4K6I_A_9RAA500_1","RETINOIC ACID RECEPTOR RXR-ALPHA","3tx7","NUCLEAR RECEPTOR SUBFAMILY 5 GROUP A MEMBER 2","Homo sapiens",5,"ALA B 349;LEU B 386;ILE B 387;ARG B 393;LEU B 405","P6L B 100 ( 3.9A);P6L B 100 (-3.8A);None;None;None","0.80A","4k6iA-3tx7B:21.7","4k6iA-3tx7B:28.90"],["4LTW_A_486A302_1","ANCESTRAL STEROID RECEPTOR 2","3tx7","NUCLEAR RECEPTOR SUBFAMILY 5 GROUP A MEMBER 2","Homo sapiens",6,"LEU B 353;VAL B 357;GLN B 374;GLN B 379;GLU B 534;ALA B 538","None","0.52A","4ltwA-3tx7B:19.4","4ltwA-3tx7B:24.23"]]