SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3txa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		 3txa CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
agalactiae) 		5 / 10 PHE A 711
PRO A 712
ILE A 658
TYR A 675
PRO A 714
 None
 1.42A 13gsA-3txaA:
undetectable		 13gsA-3txaA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_B_SASB211_1
(GLUTATHIONE
S-TRANSFERASE)		 3txa CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
agalactiae) 		5 / 9 PHE A 711
PRO A 712
ILE A 658
TYR A 675
PRO A 714
 None
 1.42A 13gsB-3txaA:
undetectable		 13gsB-3txaA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_0
(FTSJ)		 3txa CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
agalactiae) 		5 / 12 ALA A 633
GLY A 622
GLY A 642
GLY A 641
LEU A 665
 None
 0.94A 1eizA-3txaA:
undetectable		 1eizA-3txaA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_0
(FTSJ)		 3txa CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
agalactiae) 		5 / 12 ALA A 633
GLY A 622
GLY A 642
GLY A 641
LEU A 665
 None
 0.93A 1ej0A-3txaA:
undetectable		 1ej0A-3txaA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HO5_A_ADNA1604_1
(5'-NUCLEOTIDASE)		 3txa CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
agalactiae) 		5 / 11 ASN A 664
SER A 626
GLY A 641
GLY A 636
ASP A 624
 None
 1.37A 1ho5A-3txaA:
undetectable		 1ho5A-3txaA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_2
(TRANSTHYRETIN)		 3txa CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
agalactiae) 		4 / 7 LYS A 189
THR A 206
THR A 674
VAL A 672
 None
 0.65A 1ictD-3txaA:
undetectable		 1ictD-3txaA:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_1
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 3txa CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
agalactiae) 		3 / 3 THR A 211
GLU A 208
ASP A 176
 None
 0.78A 1nt2A-3txaA:
undetectable		 1nt2A-3txaA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q13_A_TESA501_1
(PROSTAGLANDIN-E2
9-REDUCTASE)		 3txa CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
agalactiae) 		4 / 6 TYR A 272
HIS A 381
PRO A 542
VAL A 538
 None
 1.42A 1q13A-3txaA:
undetectable		 1q13A-3txaA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZQ_A_PCFA954_0
(CATECHOL
1,2-DIOXYGENASE)		 3txa CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
agalactiae) 		5 / 9 THR A 383
ALA A 359
LEU A 360
GLU A 365
LEU A 319
 None
 1.13A 2azqA-3txaA:
undetectable		 2azqA-3txaA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D55_C_DVAC2_0
(ACTINOMYCIN D)		 3txa CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
agalactiae) 		3 / 3 THR A 707
PRO A 705
PRO A 699
 None
 0.83A 2d55C-3txaA:
undetectable		 2d55C-3txaA:
1.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_B_ACTB653_0
(ACETYL-COENZYME A
SYNTHETASE)		 3txa CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
agalactiae) 		4 / 4 VAL A 382
THR A 383
VAL A 538
GLY A 537
 None
 1.15A 2p2fB-3txaA:
2.8		 2p2fB-3txaA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PH9_A_GNTA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3txa CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
agalactiae) 		4 / 7 GLN A 422
TYR A 519
TYR A 529
ILE A 379
 None
 0.77A 2ph9A-3txaA:
2.4
2ph9B-3txaA:
undetectable		 2ph9A-3txaA:
16.86
2ph9B-3txaA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PH9_A_GNTA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3txa CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
agalactiae) 		4 / 7 GLN A 422
TYR A 519
TYR A 529
ILE A 531
 None
 1.14A 2ph9A-3txaA:
2.4
2ph9B-3txaA:
undetectable		 2ph9A-3txaA:
16.86
2ph9B-3txaA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBM_A_CAMA517_0
(CYTOCHROME P450-CAM)		 3txa CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
agalactiae) 		4 / 8 TYR A 272
THR A 356
THR A 533
VAL A 538
 None
 0.87A 2qbmA-3txaA:
undetectable		 2qbmA-3txaA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 3txa CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
agalactiae) 		5 / 12 ALA A 633
GLY A 622
GLY A 636
GLY A 635
GLN A 669
 None
 0.81A 3douA-3txaA:
undetectable		 3douA-3txaA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_A_ADNA438_1
(ADENOSYLHOMOCYSTEINA
SE)		 3txa CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
agalactiae) 		5 / 12 ASN A 661
LEU A 644
LEU A 628
GLY A 631
PHE A 613
 None
 1.25A 3g1uA-3txaA:
undetectable		 3g1uA-3txaA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 3txa CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
agalactiae) 		5 / 11 GLY A 385
ASP A 384
ALA A 245
GLU A 338
ALA A 353
 MG  A 801 ( 4.8A)
MG  A 801 (-2.7A)
None
None
None
 1.10A 3g89B-3txaA:
undetectable		 3g89B-3txaA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 3txa CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
agalactiae) 		5 / 12 GLY A 385
ASP A 384
ALA A 245
GLU A 338
ALA A 353
 MG  A 801 ( 4.8A)
MG  A 801 (-2.7A)
None
None
None
 1.07A 3g8bB-3txaA:
undetectable		 3g8bB-3txaA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 3txa CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
agalactiae) 		5 / 12 THR A 695
THR A 696
ILE A 603
LEU A 205
TYR A 675
 None
 1.23A 3gwxA-3txaA:
undetectable		 3gwxA-3txaA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_1
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 3txa CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
agalactiae) 		3 / 3 GLU A 575
ASP A 574
ASP A 567
 None
 0.74A 4gc9A-3txaA:
2.0		 4gc9A-3txaA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I89_B_1FLB201_1
(TRANSTHYRETIN)		 3txa CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
agalactiae) 		4 / 4 LYS A 294
ALA A 295
SER A 285
THR A 307
 None
 1.47A 4i89B-3txaA:
undetectable		 4i89B-3txaA:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB0_B_ACTB401_0
(UNCHARACTERIZED
PROTEIN)		 3txa CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
agalactiae) 		4 / 5 VAL A 584
LEU A 222
VAL A 224
PHE A 580
 None
 0.82A 4lb0B-3txaA:
undetectable		 4lb0B-3txaA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_MTLA805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3txa CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
agalactiae) 		4 / 8 SER A 555
ASN A 521
GLN A 357
PHE A 520
 None
 1.22A 5vunA-3txaA:
undetectable		 5vunA-3txaA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEC_C_RBTC601_1
(SCAFFOLD PROTEIN D13)		 3txa CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
agalactiae) 		5 / 12 VAL A 386
PRO A 495
PHE A 552
PHE A 442
ILE A 420
 None
 1.21A 6becA-3txaA:
2.9
6becB-3txaA:
2.1
6becC-3txaA:
2.7		 6becA-3txaA:
22.51
6becB-3txaA:
22.51
6becC-3txaA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_A_IXXA609_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 3txa CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
agalactiae) 		4 / 7 ILE A 643
VAL A 595
LEU A 663
LEU A 205
 None
 0.68A 6g9bA-3txaA:
0.4
6g9bB-3txaA:
undetectable		 6g9bA-3txaA:
7.40
6g9bB-3txaA:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_A_Y00A406_0
(BETA-1 ADRENERGIC
RECEPTOR)		 3txa CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
agalactiae) 		5 / 12 VAL A 386
ASN A 539
VAL A 566
ASN A 565
TYR A 563
 None
 1.32A 6h7lA-3txaA:
undetectable		 6h7lA-3txaA:
6.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_B_Y00B405_0
(BETA-1 ADRENERGIC
RECEPTOR)		 3txa CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
agalactiae) 		5 / 12 VAL A 386
ASN A 539
VAL A 566
ASN A 565
TYR A 563
 None
 1.32A 6h7lB-3txaA:
undetectable		 6h7lB-3txaA:
6.52