SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3txm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3txm 26S PROTEASOME
REGULATORY COMPLEX
SUBUNIT P42B
(Drosophila
melanogaster) 		3 / 3 THR A 325
ASP A 371
SER A 366
 None
 0.65A 2nxeA-3txmA:
undetectable		 2nxeA-3txmA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3txm 26S PROTEASOME
REGULATORY COMPLEX
SUBUNIT P42B
(Drosophila
melanogaster) 		3 / 3 THR A 325
ASP A 371
SER A 366
 None
 0.66A 2nxeB-3txmA:
undetectable		 2nxeB-3txmA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BSZ_F_RTLF178_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 3txm 26S PROTEASOME
REGULATORY COMPLEX
SUBUNIT P42B
(Drosophila
melanogaster) 		5 / 11 LEU A 183
ALA A 219
PHE A 232
ALA A 228
GLN A 213
 None
 1.47A 3bszF-3txmA:
undetectable		 3bszF-3txmA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3txm 26S PROTEASOME
REGULATORY COMPLEX
SUBUNIT P42B
(Drosophila
melanogaster) 		4 / 7 VAL A 317
ILE A 318
LEU A 190
LEU A 217
 None
 0.90A 4l1wA-3txmA:
undetectable		 4l1wA-3txmA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_4_BEZ4801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3txm 26S PROTEASOME
REGULATORY COMPLEX
SUBUNIT P42B
(Drosophila
melanogaster) 		4 / 5 LEU A 256
PHE A 232
ILE A 318
ILE A 216
 None
 0.96A 5dzk4-3txmA:
undetectable
5dzkg-3txmA:
undetectable
5dzkm-3txmA:
undetectable
5dzkn-3txmA:
undetectable		 5dzk4-3txmA:
1.59
5dzkg-3txmA:
20.25
5dzkm-3txmA:
19.18
5dzkn-3txmA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Y_BEZY801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3txm 26S PROTEASOME
REGULATORY COMPLEX
SUBUNIT P42B
(Drosophila
melanogaster) 		4 / 5 PHE A 232
ILE A 318
ILE A 216
LEU A 256
 None
 0.92A 5dzkd-3txmA:
undetectable
5dzkk-3txmA:
undetectable
5dzky-3txmA:
undetectable		 5dzkd-3txmA:
20.25
5dzkk-3txmA:
19.18
5dzky-3txmA:
1.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA406_0
(THIOREDOXIN
REDUCTASE)		 3txm 26S PROTEASOME
REGULATORY COMPLEX
SUBUNIT P42B
(Drosophila
melanogaster) 		3 / 3 HIS A 178
SER A 174
ARG A 187
 None
 0.97A 5u63A-3txmA:
undetectable		 5u63A-3txmA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_D_ZOLD401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 3txm 26S PROTEASOME
REGULATORY COMPLEX
SUBUNIT P42B
(Drosophila
melanogaster) 		4 / 7 LEU A 270
ASP A 266
ASP A 265
GLN A 263
 None
GD3  A   1 (-2.1A)
GD3  A   1 (-3.9A)
GD3  A   1 ( 4.8A)
 1.37A 6g31D-3txmA:
2.1		 6g31D-3txmA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_J_ZOLJ401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 3txm 26S PROTEASOME
REGULATORY COMPLEX
SUBUNIT P42B
(Drosophila
melanogaster) 		4 / 6 LEU A 270
ASP A 266
ASP A 265
GLN A 263
 None
GD3  A   1 (-2.1A)
GD3  A   1 (-3.9A)
GD3  A   1 ( 4.8A)
 1.28A 6g31J-3txmA:
3.4		 6g31J-3txmA:
12.69