SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ty4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		 3ty4 PROBABLE
HOMOISOCITRATE
DEHYDROGENASE
(Schizosaccharomy
ces
pombe) 		5 / 9 GLU A 228
ASP A 227
ARG A 208
ILE A 194
THR A 192
 None
 1.48A 1aj6A-3ty4A:
undetectable		 1aj6A-3ty4A:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIP_A_KTNA801_1
(CYTOCHROME P450
107A1)		 3ty4 PROBABLE
HOMOISOCITRATE
DEHYDROGENASE
(Schizosaccharomy
ces
pombe) 		5 / 12 ALA A 322
TYR A 326
LEU A  28
ALA A  25
LEU A 313
 None
 1.38A 1jipA-3ty4A:
undetectable		 1jipA-3ty4A:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 3ty4 PROBABLE
HOMOISOCITRATE
DEHYDROGENASE
(Schizosaccharomy
ces
pombe) 		5 / 12 ILE A   7
ALA A  73
LEU A  32
ILE A 325
PHE A  42
 None
 1.38A 1y0xX-3ty4A:
undetectable		 1y0xX-3ty4A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 3ty4 PROBABLE
HOMOISOCITRATE
DEHYDROGENASE
(Schizosaccharomy
ces
pombe) 		3 / 3 ALA A  25
THR A 305
PHE A  42
 None
 0.74A 2c6nB-3ty4A:
undetectable		 2c6nB-3ty4A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		 3ty4 PROBABLE
HOMOISOCITRATE
DEHYDROGENASE
(Schizosaccharomy
ces
pombe) 		4 / 6 ARG A  97
ASP A 260
SER A 259
SER A 274
 None
GOL  A 366 (-3.4A)
None
None
 1.01A 2j2pA-3ty4A:
undetectable
2j2pC-3ty4A:
undetectable		 2j2pA-3ty4A:
21.39
2j2pC-3ty4A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		 3ty4 PROBABLE
HOMOISOCITRATE
DEHYDROGENASE
(Schizosaccharomy
ces
pombe) 		4 / 6 ARG A  97
ASP A 260
SER A 259
SER A 274
 None
GOL  A 366 (-3.4A)
None
None
 1.01A 2j2pD-3ty4A:
undetectable
2j2pF-3ty4A:
undetectable		 2j2pD-3ty4A:
21.39
2j2pF-3ty4A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3ty4 PROBABLE
HOMOISOCITRATE
DEHYDROGENASE
(Schizosaccharomy
ces
pombe) 		5 / 12 GLU A  70
SER A 284
ALA A 275
LEU A 313
MET A  29
 None
 1.21A 2xkwB-3ty4A:
undetectable		 2xkwB-3ty4A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_A_ACTA501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 3ty4 PROBABLE
HOMOISOCITRATE
DEHYDROGENASE
(Schizosaccharomy
ces
pombe) 		4 / 7 ASP A 260
VAL A 109
ARG A 107
ILE A 124
 GOL  A 366 (-3.4A)
None
GOL  A 366 ( 4.7A)
None
 1.14A 2yfbA-3ty4A:
undetectable		 2yfbA-3ty4A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_B_ACTB501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 3ty4 PROBABLE
HOMOISOCITRATE
DEHYDROGENASE
(Schizosaccharomy
ces
pombe) 		4 / 6 ASP A 260
VAL A 109
ARG A 107
ILE A 124
 GOL  A 366 (-3.4A)
None
GOL  A 366 ( 4.7A)
None
 1.22A 2yfbB-3ty4A:
undetectable		 2yfbB-3ty4A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_4
(HIV-1 PROTEASE)		 3ty4 PROBABLE
HOMOISOCITRATE
DEHYDROGENASE
(Schizosaccharomy
ces
pombe) 		4 / 4 LEU A  11
ASP A  15
VAL A  21
THR A 305
 None
 1.09A 3cyxB-3ty4A:
undetectable		 3cyxB-3ty4A:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		 3ty4 PROBABLE
HOMOISOCITRATE
DEHYDROGENASE
(Schizosaccharomy
ces
pombe) 		5 / 12 PHE A 315
ALA A 322
ALA A 275
VAL A 277
ILE A 177
 None
 1.15A 3czhA-3ty4A:
undetectable		 3czhA-3ty4A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TPX_E_ACTE204_0
(E3 UBIQUITIN-PROTEIN
LIGASE MDM2)		 3ty4 PROBABLE
HOMOISOCITRATE
DEHYDROGENASE
(Schizosaccharomy
ces
pombe) 		3 / 3 LYS A 188
PRO A 189
LEU A 190
 None
None
GOL  A 364 ( 4.2A)
 0.84A 3tpxE-3ty4A:
undetectable		 3tpxE-3ty4A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B9Z_A_ACRA1818_1
(ALPHA-GLUCOSIDASE,
PUTATIVE, ADG31B)		 3ty4 PROBABLE
HOMOISOCITRATE
DEHYDROGENASE
(Schizosaccharomy
ces
pombe) 		5 / 12 LEU A 339
ILE A 352
LEU A 271
ARG A 307
ASP A 330
 None
 1.11A 4b9zA-3ty4A:
undetectable		 4b9zA-3ty4A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_A_ADNA401_1
(ADENOSINE KINASE)		 3ty4 PROBABLE
HOMOISOCITRATE
DEHYDROGENASE
(Schizosaccharomy
ces
pombe) 		5 / 12 ALA A  14
THR A  63
LEU A  67
GLY A  50
ASP A  15
 None
GOL  A 363 (-3.9A)
None
None
None
 1.02A 4dc3A-3ty4A:
undetectable		 4dc3A-3ty4A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_A_BEZA1000_0
(BENZOATE-COENZYME A
LIGASE)		 3ty4 PROBABLE
HOMOISOCITRATE
DEHYDROGENASE
(Schizosaccharomy
ces
pombe) 		4 / 7 ALA A 300
ALA A  78
GLY A  77
GLY A  16
 GOL  A 365 (-4.0A)
None
None
None
 0.68A 4eatA-3ty4A:
undetectable		 4eatA-3ty4A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 3ty4 PROBABLE
HOMOISOCITRATE
DEHYDROGENASE
(Schizosaccharomy
ces
pombe) 		5 / 12 MET A 312
LEU A 313
LEU A  28
ILE A   7
LEU A  75
 None
 1.22A 4j24B-3ty4A:
undetectable		 4j24B-3ty4A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 3ty4 PROBABLE
HOMOISOCITRATE
DEHYDROGENASE
(Schizosaccharomy
ces
pombe) 		4 / 6 THR A 353
LEU A  75
LEU A 313
GLU A 314
 None
 1.09A 4nc3A-3ty4A:
1.8		 4nc3A-3ty4A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_B_RBFB402_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 3ty4 PROBABLE
HOMOISOCITRATE
DEHYDROGENASE
(Schizosaccharomy
ces
pombe) 		5 / 10 ILE A  93
ASN A 105
LEU A 311
VAL A 272
PHE A  76
 None
 1.48A 4r3aB-3ty4A:
undetectable		 4r3aB-3ty4A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_2
(CYTOCHROME P450
21-HYDROXYLASE)		 3ty4 PROBABLE
HOMOISOCITRATE
DEHYDROGENASE
(Schizosaccharomy
ces
pombe) 		3 / 3 LEU A 339
VAL A 329
ASP A 330
 None
 0.56A 4y8wC-3ty4A:
undetectable		 4y8wC-3ty4A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 3ty4 PROBABLE
HOMOISOCITRATE
DEHYDROGENASE
(Schizosaccharomy
ces
pombe) 		5 / 12 GLY A  48
ILE A  93
LEU A  96
GLY A  77
ILE A  12
 None
 0.88A 5d4uC-3ty4A:
undetectable		 5d4uC-3ty4A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 3ty4 PROBABLE
HOMOISOCITRATE
DEHYDROGENASE
(Schizosaccharomy
ces
pombe) 		5 / 12 GLY A  48
ILE A  93
LEU A  96
GLY A  77
ILE A  12
 None
 0.86A 5d4uD-3ty4A:
undetectable		 5d4uD-3ty4A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 3ty4 PROBABLE
HOMOISOCITRATE
DEHYDROGENASE
(Schizosaccharomy
ces
pombe) 		5 / 9 LEU A  75
LEU A   9
ALA A 275
VAL A 277
ALA A  73
 None
 1.24A 5g44A-3ty4A:
undetectable		 5g44A-3ty4A:
20.27